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Syn2 Gene Detail
Summary
  • Symbol
    Syn2
  • Name
    synapsin II
  • Synonyms
    2900074L19Rik, Synapsin IIa, Synapsin IIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:103020
    NCBI Gene: 20965
  • Gene Overview
    MyGene.info: SYN2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115134902-115282006 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 53.20 cM, cytoband F
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1002 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103020
protein coding gene Chr6:115134902-115282626 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031145
protein coding gene Chr6:117739969-117894188 (+)
A/J MGP_AJ_G0031114
protein coding gene Chr6:113223014-113368087 (+)
AKR/J MGP_AKRJ_G0031045
protein coding gene Chr6:116261872-116423981 (+)
BALB/cJ MGP_BALBcJ_G0031125
protein coding gene Chr6:113036286-113181967 (+)
C3H/HeJ MGP_C3HHeJ_G0030581
protein coding gene Chr6:67877425-68036203 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031584
protein coding gene Chr6:120737413-120898714 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028748
protein coding gene Chr6:110239384-110384962 (+)
CAST/EiJ MGP_CASTEiJ_G0030232
protein coding gene Chr6:116616060-116774550 (+)
CBA/J MGP_CBAJ_G0030811
protein coding gene Chr6:125493617-125656372 (+)
DBA/2J MGP_DBA2J_G0030964
protein coding gene Chr6:112154472-112301812 (+)
FVB/NJ MGP_FVBNJ_G0030918
protein coding gene Chr6:111316576-111465793 (+)
LP/J MGP_LPJ_G0031044
protein coding gene Chr6:117761484-117910696 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030952
protein coding gene Chr6:129683388-129850706 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031611
protein coding gene Chr6:116277437-116433334 (+)
PWK/PhJ MGP_PWKPhJ_G0029948
protein coding gene Chr6:111149195-111300302 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029776
protein coding gene Chr6:114984525-115133196 (+)
WSB/EiJ MGP_WSBEiJ_G0030316
protein coding gene Chr6:116524355-116681373 (+)



Homology
more
  • Human Ortholog
    SYN2, synapsin II
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYN2, synapsin II
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SYNII
  • Links
    NCBI Gene ID: 6854
    neXtProt AC: NX_Q92777
    UniProt: Q92777

  • Chr Location
    3p25.2; chr3:12004360-12192032 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Syn2 mouse models; 1 with human SYN2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in central nervous system abnormalities. One model showed delayed synapse formation and decreased brain weight while another allele showed decreased post-tetanic potentiation and increased synaptic depression and development of convulsive seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009394 Ensembl Gene Model | MGI Sequence Detail 147105 C57BL/6J ±  kb
    transcript ENSMUST00000009538 Ensembl | MGI Sequence Detail 2708 Not Applicable  
    polypeptide ENSMUSP00000009538 Ensembl | MGI Sequence Detail 586 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 7
      cDNA 11
      Primer pair 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-23857, MGI:1914524, MGI:2141475, MGI:2141484
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 15
      Diseases 3
      Gene Ontology 12
      Phenotypes 52
    • Earliest
      J:3250 Oettinger HF, et al., Chromosome mapping of the murine syndecan gene. Genomics. 1991 Oct;11(2):334-8
    • Latest
      J:255335 Tan GH, et al., PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Cell Res. 2018 Jan;28(1):90-110

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory