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Syn2
Gene Detail
Symbol

Name
ID
Syn2
synapsin II
MGI:103020
Synonyms
2900074L19Rik, Synapsin IIa, Synapsin IIb
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.20 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr6:115134902-115282626 bp, + strand
From NCBI annotation of GRCm38

  147725 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49348  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Syn2

Human
homologs
Human Homolog SYN2, synapsin II
NCBI Gene ID 6854
neXtProt AC  NX_Q92777
Human Synonyms  SYNII
Human Chr (Location)  3p25; chr3:12004366-12192032 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SYN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in central nervous system abnormalities. One model showed delayed synapse formation and decreased brain weight while another allele showed decreased post-tetanic potentiation and increased synaptic depression and development of convulsive seizures.
 
Human Diseases Modeled Using Mouse Syn2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Syn2 interacts with 356 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process neurotransmitter secretion
Component cell, cell junction, ...
Function ATP binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (149)    Tissues (55)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 149
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(7) cDNA(9) Primer pair(3)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000009394 (Evidence)
Entrez Gene20965 (Evidence)
DoTSDT.60108966, DT.55215112, DT.110488788, DT.101205306, DT.101195785, DT.91312661, DT.87036974
Consensus CDS ProjectCCDS51874.1, CCDS51875.1
International Mouse Knockout Project StatusSyn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20965 NCBI Gene Model | MGI Sequence Detail 147725 C57BL/6J ±  kb
transcript NM_013681 RefSeq | MGI Sequence Detail 3858 C57BL/6 
polypeptide Q64332 UniProt | EBI | MGI Sequence Detail 586 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(1007 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1009)
Protein-related
information
ResourceIDDescription
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR016185 Pre-ATP-grasp domain
InterPro IPR001359 Synapsin
InterPro IPR020898 Synapsin, ATP-binding domain
InterPro IPR019735 Synapsin, conserved site
InterPro IPR019736 Synapsin, phosphorylation site
InterPro IPR020897 Synapsin, pre-ATP-grasp domain
Protein Ontology PR:000015871 synapsin-2
Graphical View of Protein Domain Structure
References
(Earliest) J:3250 Oettinger HF, et al., Chromosome mapping of the murine syndecan gene. Genomics. 1991 Oct;11(2):334-8
(Latest) J:203121 Corradi A, et al., SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth. Hum Mol Genet. 2014 Jan 1;23(1):90-103
All references(94)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-23857, MGI:1914524, MGI:2141475, MGI:2141484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory