Syn2
Gene Detail

Symbol Name ID

Syn2 synapsin II MGI:103020

Synonyms

2900074L19Rik, Synapsin IIa, Synapsin IIb

Feature Type

protein coding gene

Genetic Map

Chromosome 6

53.20 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr6:115134902-115282626 bp, + strand From NCBI annotation of GRCm38   147725 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49348  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Syn2

Human homologs

Human Homolog		SYN2, synapsin II
NCBI Gene ID		6854
neXtProt AC		NX_Q92777
Human Synonyms		SYNII, SYNIIa, SYNIIb
Human Chr (Location)		3p25; chr3:12182150-12233532 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SYN2

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutation of this gene results in central nervous system abnormalities. One model showed delayed synapse formation and decreased brain weight while another allele showed decreased post-tetanic potentiation and increased synaptic depression and development of convulsive seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	neurotransmitter secretion
Component	cell junction, synapse, ...
Function	ATP binding, calcium-dependent protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (149)    Tissues (55)    Images (36)
Theiler Stages: 19, 21, 23, 28

Assay Type	Results
RNA in situ	149

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(7) cDNA(7) Primer pair(3)
Microarray probesets(9)

Other database links

Ensembl Gene Model	ENSMUSG00000009394 (Evidence)
Entrez Gene	20965 (Evidence)
DoTS	DT.101195785, DT.101205306, DT.110488788, DT.55215112, DT.60108966, DT.87036974, DT.91312661
Consensus CDS Project	CCDS51874.1, CCDS51875.1
International Mouse Knockout Project Status	Syn2

Sequences

Length	Strain/Species
genomic	20965	NCBI Gene Model | MGI Sequence Detail	147725	C57BL/6J
transcript	NM_013681	RefSeq | MGI Sequence Detail	3870	C57BL/6
polypeptide	Q64332	UniProt | EBI | MGI Sequence Detail	586	Not Applicable

All sequences(36) RefSeq(4) UniProt(2)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(699 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013815	ATP-grasp fold, subdomain 1
InterPro	IPR013816	ATP-grasp fold, subdomain 2
InterPro	IPR016185	Pre-ATP-grasp domain
InterPro	IPR001359	Synapsin
InterPro	IPR020898	Synapsin, ATP-binding domain
InterPro	IPR019735	Synapsin, conserved site
InterPro	IPR019736	Synapsin, phosphorylation site
InterPro	IPR020897	Synapsin, pre-ATP-grasp domain
Protein Ontology	PR:000015871	synapsin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:3250 Oettinger HF, et al., Chromosome mapping of the murine syndecan gene. Genomics. 1991 Oct;11(2):334-8
(Latest) J:187688 Fornasiero EF, et al., Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner. J Neurosci. 2012 Aug 29;32(35):12214-27
All references(84)

Other accession IDs

MGD-MRK-23857, MGI:1914524, MGI:2141475, MGI:2141484