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Il15
Gene Detail
Symbol

Name
ID
Il15
interleukin 15
MGI:103014
Feature Type
protein coding gene
Genetic Map
Chromosome 8
39.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr8:82331624-82402586 bp, - strand
From NCBI annotation of GRCm38

  70963 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:487  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-15
Gene Tree: Il15

Human
homologs
Human Homolog IL15, interleukin 15
NCBI Gene ID 3600
neXtProt AC  NX_P40933
Human Synonyms  IL-15
Human Chr (Location)  4q31; chr4:141636596-141733987 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene have normal life spans but display a variety of immune system abnormalities and maternal placental defects.
 
Interactions
Il15 interacts with 56 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cell maturation, extrathymic T cell selection, ...
Component cell surface, cytoplasm, ...
Function cytokine activity, cytokine receptor binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (26)    Tissues (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 26
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(6) cDNA(8) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031712 (Evidence)
Entrez Gene16168 (Evidence)
DFCITC1583946, TC1591681, TC1620575
DoTSDT.110871937, DT.40135593, DT.94231639, DT.97358040
NIA Mouse Gene IndexU030010, U066722
PDB2PSM
Consensus CDS ProjectCCDS40401.1
International Mouse Knockout Project StatusIl15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16168 NCBI Gene Model | MGI Sequence Detail 70963 C57BL/6J ±  kb
transcript NM_008357 RefSeq | MGI Sequence Detail 1297 C57BL/6 
polypeptide P48346 UniProt | EBI | MGI Sequence Detail 162 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(26) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(639 from dbSNP Build 137)    SNPs within 2kb including multiple locations(641)
Protein-related
information
ResourceIDDescription
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR020439 Interleukin-15
InterPro IPR003443 Interleukin-15-like
InterPro IPR020466 Interleukin-15, mammal
Protein Ontology PR:000001373 interleukin-15
Graphical View of Protein Domain Structure
References
(Earliest) J:23246 Anderson DM, et al., Chromosomal assignment and genomic structure of Il15. Genomics. 1995 Feb 10;25(3):701-6
(Latest) J:212399 Srivastava S, et al., Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med. 2014 May 5;211(5):961-74
All references(262)
Other
accession IDs
MGD-MRK-23851, MGI:2142577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory