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E2f4
Gene Detail
 Symbol
Name
ID
E2f4
E2F transcription factor 4
MGI:103012
Synonyms 2010111M04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:105297663-105305369 bp, + strand
From Ensembl annotation of GRCm38

  7707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor E2F
Gene Tree: E2f4

Human
homologs
Human Homolog E2F4, E2F transcription factor 4, p107/p130-binding
NCBI Gene ID 1874
neXtProt AC  NX_Q16254
Human Synonyms  E2F-4
Human Chr (Location)  16q21-q22; chr16:67192165-67198918 (+)  GRCh38
Alleles
and
phenotypes
All alleles(18) : Targeted(3) Gene trapped(15)
 
Homozygous null mice die postnatally of an increased susceptibility to bacterial infection and exhibit craniofacial defects, erythroid abnormalities, and growth retardation.
 
Human Diseases Modeled Using Mouse E2f4 (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process blood circulation, cell cycle, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (278)    Tissues (198)    Images (56)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 195
Northern blot 9
Western blot 26
RT-PCR 43
cDNA source data(67)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(72) cDNA(67) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000014859 (Evidence)
Entrez Gene104394 (Evidence)
UniGene34554
DFCITC1578435, TC1603667
DoTSDT.101305806, DT.531602
NIA Mouse Gene IndexU046903
Consensus CDS ProjectCCDS40456.1
International Mouse Knockout Project StatusE2f4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014859 Ensembl Gene Model | MGI Sequence Detail 7707 C57BL/6J ±  kb
transcript ENSMUST00000015003 Ensembl | MGI Sequence Detail 1992 Not Applicable 
polypeptide ENSMUSP00000015003 Ensembl | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015633 E2F Family
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006855 transcription factor E2F4
References (Earliest) J:21634 Beijersbergen RL, et al., E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 1994 Nov 15;8(22):2680-90
(Latest) J:191198 Kopecky BJ, et al., Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability. Dev Dyn. 2013 Feb;242(2):132-47
All references(85)
Other
accession IDs
MGD-MRK-23849, MGI:1919312, MGI:2142532

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory