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E2f4 Gene Detail
Summary
  • Symbol
    E2f4
  • Name
    E2F transcription factor 4
  • Synonyms
    2010111M04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103012
    NCBI Gene: 104394
  • Gene Overview
    MyGene.info: E2F4
Location & Maps
more
  • Sequence Map
    Chr8:105297663-105305369 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7707 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    E2F4, E2F transcription factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    E2F4, E2F transcription factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    E2F-4
  • Links
    NCBI Gene ID: 1874
    neXtProt AC: NX_Q16254

  • Chr Location
    16q22.1; chr16:67192165-67198918 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with E2f4 mouse models

Human Disease Mouse Models
       Macrocytosis, Familial   OMIM: 600084 View 1 model
Otitis Media, Susceptibility to   OMIM: 166760 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die postnatally of an increased susceptibility to bacterial infection and exhibit craniofacial defects, erythroid abnormalities, and growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014859 Ensembl Gene Model | MGI Sequence Detail 7707 C57BL/6J ±  kb
transcript ENSMUST00000015003 Ensembl | MGI Sequence Detail 1992 Not Applicable  
polypeptide ENSMUSP00000015003 Ensembl | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006855 transcription factor E2F4
  • InterPro Domains
    IPR003316 E2F/DP family, winged-helix DNA-binding domain
    IPR015633 E2F Family
    IPR032198 E2F transcription factor, CC-MB domain
    IPR028312 Transcription factor E2F4
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 72
    cDNA 67
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-23849, MGI:1919312, MGI:2142532
References
more
  • Summaries
    All 85
    Developmental Gene Expression 24
    Diseases 1
    Gene Ontology 13
    Phenotypes 25
  • Earliest
    J:21634 Beijersbergen RL, et al., E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 1994 Nov 15;8(22):2680-90
  • Latest
    J:228346 Danielian PS, et al., E2f4 and E2f5 are essential for the development of the male reproductive system. Cell Cycle. 2016 Jan 17;15(2):250-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory