E2f4
Gene Detail

Symbol Name ID

E2f4 E2F transcription factor 4 MGI:103012

Synonyms

2010111M04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:105297663-105305369 bp, + strand From Ensembl annotation of GRCm38   7707 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor E2F
Gene Tree: E2f4

Human homologs

Human Homolog		E2F4, E2F transcription factor 4, p107/p130-binding
NCBI Gene ID		1874
neXtProt AC		NX_Q16254
Human Synonyms		E2F-4
Human Chr (Location)		16q21-q22; chr16:67226068-67232821 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(3) Gene trapped(15)
 

Homozygous null mice die postnatally of an increased susceptibility to bacterial infection and exhibit craniofacial defects, erythroid abnormalities, and growth retardation.

 
Human Diseases Modeled Using Mouse E2f4 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	blood circulation, cell cycle, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (278)    Tissues (198)    Images (56)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	195
Northern blot	9
Western blot	26
RT-PCR	43

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(71) cDNA(66) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000014859 (Evidence)
Entrez Gene	104394 (Evidence)
UniGene	34554
DFCI	TC1578435, TC1603667
DoTS	DT.101305806, DT.531602
NIA Mouse Gene Index	U046903
Consensus CDS Project	CCDS40456.1
International Mouse Knockout Project Status	E2f4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000014859	Ensembl Gene Model | MGI Sequence Detail	7707	C57BL/6J
transcript	ENSMUST00000015003	Ensembl | MGI Sequence Detail	1992	Not Applicable
polypeptide	ENSMUSP00000015003	Ensembl | MGI Sequence Detail	410	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015633	E2F Family
InterPro	IPR003316	Transcription factor E2F/dimerisation partner (TDP)
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000006855	transcription factor E2F4

References

(Earliest) J:21634 Beijersbergen RL, et al., E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 1994 Nov 15;8(22):2680-90
(Latest) J:191198 Kopecky BJ, et al., Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability. Dev Dyn. 2013 Feb;242(2):132-47
All references(84)

Other accession IDs

MGD-MRK-23849, MGI:1919312, MGI:2142532