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Ccr7 Gene Detail
Summary
  • Symbol
    Ccr7
  • Name
    chemokine (C-C motif) receptor 7
  • Synonyms
    CD197, Cmkbr7, EBI1, Ebi1h
  • Feature Type
    protein coding gene
  • IDs
    MGI:103011
    NCBI Gene: 12775
  • Gene Overview
    MyGene.info: CCR7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:99144196-99155077 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10882 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.92 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CCR7, C-C motif chemokine receptor 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CCR7, C-C motif chemokine receptor 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
  • Links
    NCBI Gene ID: 1236
    neXtProt AC: NX_P32248
    UniProt: P32248

  • Chr Location
    17q21.2; chr17:40553769-40565484 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ccr7 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 4 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    182 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice exhibit an impaired primary immune response. Dendritic cells, B, T and T regulatory cells show impaired migration to the lymph nodes and secondary lymph organs exhibit morphological abnormalities. Lymphocytic infiltrates to the pancreas, lung and stomach are observed in aged mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006448 VEGA Gene Model | MGI Sequence Detail 10882 C57BL/6J ±  kb
    transcript OTTMUST00000014735 VEGA | MGI Sequence Detail 1978 Not Applicable  
    polypeptide OTTMUSP00000006846 VEGA | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      31 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23848
    References
    more
    • Summaries
      All 282
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 23
      Phenotypes 182
    • Earliest
      J:21104 Schweickart VL, et al., Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 1994 Oct;23(3):643-50
    • Latest
      J:264313 Kim YI, et al., CX3CR1(+) Macrophages and CD8(+) T Cells Control Intestinal IgA Production. J Immunol. 2018 Aug 15;201(4):1287-1294

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory