Ccr7
Gene Detail

Symbol Name ID

Ccr7 chemokine (C-C motif) receptor 7 MGI:103011

Synonyms

CD197, Cmkbr7, EBI1, Ebi1h

Feature Type

protein coding gene

Genetic Map

Chromosome 11

62.92 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:99144196-99155077 bp, - strand From VEGA annotation of GRCm38   10882 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ccr7 ± 2 cM)

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr7

Human ortholog

CCR7 chemokine (C-C motif) receptor 7 NCBI Gene ID 1236
Human Synonyms: BLR2, CD197, CDw197, CMKBR7, EBI1
Human Chr17:38710021-38721736 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous mice exhibit an impaired primary immune response. Dendritic cells, B, T and T regulatory cells show impaired migration to the lymph nodes and secondary lymph organs exhibit morphological abnormalities. Lymphocytic infiltrates to the pancreas, lung and stomach are observed in aged mice.

 
Human Diseases Modeled Using Mouse Ccr7 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (68 annotations)

Process	actin cytoskeleton organization, activation of JUN kinase activity, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (150)    Tissues (91)    Images (16)
Theiler Stages: 19, 23, 26, 28

Assay Type	Results
RNA in situ	54
In situ reporter (knock in)	55
RT-PCR	41

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006448 (Evidence)
Ensembl Gene Model	ENSMUSG00000037944 (Evidence)
Entrez Gene	12775 (Evidence)
UniGene	2932
DFCI	TC1580154
DoTS	DT.530796
NIA Mouse Gene Index	U033382
Consensus CDS Project	CCDS25373.1
International Mouse Knockout Project Status	Ccr7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006448	VEGA Gene Model | MGI Sequence Detail	10882	C57BL/6J
transcript	OTTMUST00000014735	VEGA | MGI Sequence Detail	1978	Not Applicable
polypeptide	OTTMUSP00000006846	VEGA | MGI Sequence Detail	378	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001718	CC chemokine receptor, type 7
InterPro	IPR000355	Chemokine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001203	C-C chemokine receptor type 7

References

(Earliest) J:21104 Schweickart VL, et al., Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 1994 Oct;23(3):643-50
(Latest) J:193483 Plantinga M, et al., Conventional and Monocyte-Derived CD11b(+) Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen. Immunity. 2013 Feb 21;38(2):322-35
All references(186)

Other accession IDs

MGD-MRK-23848