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Ccr7
Gene Detail
Symbol

Name
ID
Ccr7
chemokine (C-C motif) receptor 7
MGI:103011
Synonyms
CD197, Cmkbr7, EBI1, Ebi1h
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.92 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:99144196-99155077 bp, - strand
From VEGA annotation of GRCm38

  10882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr7

Human
homologs
Human Homolog CCR7, chemokine (C-C motif) receptor 7
NCBI Gene ID 1236
neXtProt AC  NX_P32248
Human Synonyms  BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
Human Chr (Location)  17q12-q21.2; chr17:40553769-40565484 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice exhibit an impaired primary immune response. Dendritic cells, B, T and T regulatory cells show impaired migration to the lymph nodes and secondary lymph organs exhibit morphological abnormalities. Lymphocytic infiltrates to the pancreas, lung and stomach are observed in aged mice.
 
Human Diseases Modeled Using Mouse Ccr7 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ccr7 interacts with 115 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process actin cytoskeleton organization, activation of JUN kinase activity, ...
Component cell, cell surface, ...
Function C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (150)    Tissues (91)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 54
In situ reporter (knock in) 55
RT-PCR 41
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006448 (Evidence)
Ensembl Gene ModelENSMUSG00000037944 (Evidence)
Entrez Gene12775 (Evidence)
UniGene2932
DFCITC1580154
DoTSDT.530796, DT.101379634
NIA Mouse Gene IndexU033382
Consensus CDS ProjectCCDS25373.1
International Mouse Knockout Project StatusCcr7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006448 VEGA Gene Model | MGI Sequence Detail 10882 C57BL/6J ±  kb
transcript OTTMUST00000014735 VEGA | MGI Sequence Detail 1978 Not Applicable 
polypeptide OTTMUSP00000006846 VEGA | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001718 CC chemokine receptor 7
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001203 C-C chemokine receptor type 7
References
(Earliest) J:21104 Schweickart VL, et al., Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 1994 Oct;23(3):643-50
(Latest) J:209986 Benahmed F, et al., Multiple CD11c+ cells collaboratively express IL-1beta to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth. J Immunol. 2014 May 1;192(9):4153-63
All references(210)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-23848

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory