Ccr7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ccr7
C-C motif chemokine receptor 7
MGI:103011

50 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ccr7^Gt(hpk)Byg/Ccr7^Gt(hpk)Byg involves: 129 * C57BL/6	enhanced long-term potentiation	J:161269
Ccr7^Gt(hpk)Byg/Ccr7^Gt(hpk)Byg involves: 129 * C57BL/6	normal nervous system phenotype	J:161269
Ccr7^m1Btlr/Ccr7⁺ C57BL/6J-Ccr7^m1Btlr	decreased macrophage cell number	J:221477
Ccr7^m1Btlr/Ccr7^m1Btlr C57BL/6J-Ccr7^m1Btlr	decreased macrophage cell number	J:221477
Ccr7^m1Btlr/Ccr7^m1Btlr C57BL/6J-Ccr7^m1Btlr	increased single-positive T cell number	J:221477
Ccr7^tm1Dgen/Ccr7^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	chronic inflammation	J:101679
Ccr7^tm1Rfor/Ccr7^tm1Rfor B6.129P2(C)-Ccr7^tm1Rfor/J	decreased susceptibility to bacterial infection	J:210086
Ccr7^tm1Rfor/Ccr7^tm1Rfor B6.129P2-Ccr7^tm1Rfor	abnormal dendritic cell physiology	J:183989
	abnormal exocrine gland morphology	J:110910
	abnormal lacrimal gland morphology	J:110910
	abnormal leukocyte migration	J:93960, J:110910
	abnormal parotid gland morphology	J:110910
	abnormal physiological response to xenobiotic	J:110910
	abnormal submandibular gland morphology	J:110910
	abnormal thymus cortex morphology	J:93960
	normal immune system phenotype	J:93960
	increased inflammatory response	J:110910
	increased susceptibility to autoimmune disorder	J:110910
	lacrimal gland inflammation	J:110910
	parotid gland inflammation	J:110910
	salivary gland inflammation	J:110910
	small thymus medulla	J:93960
	submandibular gland inflammation	J:110910
Ccr7^tm1Rfor/Ccr7^tm1Rfor involves: 129/Sv * 129P2/OlaHsd * C57BL/6	abnormal dendritic cell physiology	J:134784
Ccr7^tm1Rfor/Ccr7^tm1Rfor involves: 129P2/OlaHsd	abnormal dendritic cell chemotaxis	J:223508
	decreased CD11b-high dendritic cell number	J:223508
	decreased CD103-positive CD11b-low dendritic cell number	J:223508
Ccr7^tm1Rfor/Ccr7^tm1Rfor involves: 129P2/OlaHsd * BALB/c	abnormal B cell activation	J:57976
	abnormal B cell physiology	J:57976
	abnormal class switch recombination	J:57976
	abnormal dendritic cell physiology	J:57976
	abnormal humoral immune response	J:57976
	abnormal leukocyte migration	J:57976
	abnormal lymph node cortex morphology	J:57976
	abnormal lymph node germinal center morphology	J:57976
	abnormal lymph node T cell domain morphology	J:57976
	abnormal Peyer's patch T cell area morphology	J:57976
	abnormal spleen marginal sinus morphology	J:57976
	abnormal spleen periarteriolar lymphoid sheath morphology	J:57976
	abnormal spleen red pulp morphology	J:57976
	abnormal T cell physiology	J:57976
	decreased CD4-positive, alpha-beta T cell number	J:57976
	decreased dendritic cell number	J:57976
	decreased IgG3 level	J:57976
	decreased susceptibility to type IV hypersensitivity reaction	J:57976
	decreased T cell number	J:57976
	enlarged spleen	J:57976
	increased CD4-positive, alpha-beta T cell number	J:57976
	increased IgE level	J:57976
	increased IgG1 level	J:57976
	increased IgG2a level	J:57976
	increased T cell number	J:57976
	small lymph nodes	J:57976
	small Peyer's patches	J:57976

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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