Txk
Gene Detail

Symbol Name ID

Txk TXK tyrosine kinase MGI:102960

Synonyms

A130089B16Rik, Btkl, PTK4, Rlk

Feature Type

protein coding gene

Genetic Map

Chromosome 5

38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr5:72695978-72752773 bp, - strand From NCBI annotation of GRCm38   56796 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Txk

Human homologs

Human Homolog		TXK, TXK tyrosine kinase
NCBI Gene ID		7294
neXtProt AC		NX_P42681
Human Synonyms		BTKL, PSCTK5, PTK4, RLK, TKL
Human Chr (Location)		4p12; chr4:48068410-48136273 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene results in increased susceptibility to parasitic (Toxoplasma gondii) infection and decreased cytokine secretion in stimulated splenocytes.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	activation of phospholipase C activity, adaptive immune response, ...
Component	cytoplasm, membrane, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (129)    Tissues (26)    Images (27)
Theiler Stages: 21, 23, 24, 25, 28

Assay Type	Results
RNA in situ	87
Northern blot	40
RT-PCR	2

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(1) cDNA(37) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000054892 (Evidence)
Entrez Gene	22165 (Evidence)
UniGene	3264
DFCI	TC1582563, TC1598104, TC1716694
DoTS	DT.101264197, DT.101328571, DT.101365216, DT.488231, DT.91338514, DT.91338516, DT.91429333
EC	2.7.10.2
Consensus CDS Project	CCDS19334.1, CCDS51514.1
International Mouse Knockout Project Status	Txk

Sequences

Length	Strain/Species
genomic	22165	NCBI Gene Model | MGI Sequence Detail	56796	C57BL/6J
transcript	NM_001122754	RefSeq | MGI Sequence Detail	2256	C57BL/6
polypeptide	P42682	UniProt | EBI | MGI Sequence Detail	527	Not Applicable

All sequences(39) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(312 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
Protein Ontology	PR:000016850	tyrosine-protein kinase TXK

Graphical View of Protein Domain Structure

References

(Earliest) J:22509 Hu Q, et al., Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J Biol Chem. 1995 Jan 27;270(4):1928-34
(Latest) J:184083 Qi Q, et al., A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. J Immunol. 2012 Apr 15;188(8):3611-9
All references(56)

Other accession IDs

MGD-MRK-23796, MGI:2444219