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Txk
Gene Detail
Symbol

Name
ID
Txk
TXK tyrosine kinase
MGI:102960
Synonyms
A130089B16Rik, Btkl, PTK4, Rlk
Feature Type
protein coding gene
Genetic Map
Chromosome 5
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:72695978-72752777 bp, - strand
From VEGA annotation of GRCm38

  56800 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TXK
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Txk

Human
homologs
TXK, TXK tyrosine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7294
neXtProt AC: NX_P42681

Human Synonyms: BTKL, PSCTK5, PTK4, RLK, TKL

Human Chr (Location): 4p12; chr4:48066393-48134256 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Txk (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased susceptibility to parasitic (Toxoplasma gondii) infection and decreased cytokine secretion in stimulated splenocytes.
 
Phenotype Images(4)
Interactions
Txk interacts with 98 markers (Mir23a, Mir23b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process activation of phospholipase C activity, adaptive immune response, ...
Component cytoplasm, extrinsic component of cytoplasmic side of plasma membrane, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (129)    Tissues (26)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 87
Northern blot 40
RT-PCR 2
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(36) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000054700 (Evidence)
Ensembl Gene Model ENSMUSG00000054892 (Evidence)
Entrez Gene 22165 (Evidence)
UniGene 3264
DFCI TC1582563, TC1598104, TC1716694
DoTS DT.101264197, DT.101328571, DT.101365216, DT.488231, DT.91338514, DT.91338516, DT.91429333, DT.94133212
EC 2.7.10.2
Consensus CDS Project CCDS19334.1, CCDS51514.1, CCDS80298.1, CCDS80299.1
International Mouse Phenotyping Consortium Status Txk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054700 VEGA Gene Model | MGI Sequence Detail 56800 C57BL/6J ±  kb
transcript OTTMUST00000135585 VEGA | MGI Sequence Detail 2260 Not Applicable 
polypeptide OTTMUSP00000071727 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(3) : SNPs within 2kb(527 from dbSNP Build 137)    SNPs within 2kb including multiple locations(533)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 SH3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000016850 tyrosine-protein kinase TXK
References
(Earliest) J:22509 Hu Q, et al., Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J Biol Chem. 1995 Jan 27;270(4):1928-34
(Latest) J:184083 Qi Q, et al., A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. J Immunol. 2012 Apr 15;188(8):3611-9
All references(55)
Other
accession IDs
MGD-MRK-23796, MGI:2444219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory