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Txk Gene Detail
Summary
  • Symbol
    Txk
  • Name
    TXK tyrosine kinase
  • Synonyms
    A130089B16Rik, Btkl, PTK4, Rlk
  • Feature Type
    protein coding gene
  • IDs
    MGI:102960
    NCBI Gene: 22165
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:72853321-72910120 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    527 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102960
protein coding gene Chr5:72853321-72910337 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029616
protein coding gene Chr5:72637360-72701306 (-)
A/J MGP_AJ_G0029584
protein coding gene Chr5:69931496-69988926 (-)
AKR/J MGP_AKRJ_G0029532
protein coding gene Chr5:72169335-72229232 (-)
BALB/cJ MGP_BALBcJ_G0029592
protein coding gene Chr5:70626483-70683255 (-)
C3H/HeJ MGP_C3HHeJ_G0029317
protein coding gene Chr5:72546384-72609959 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030047
protein coding gene Chr5:75629756-75690818 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027289
protein coding gene Chr5:65638367-65695655 (-)
CAST/EiJ MGP_CASTEiJ_G0028726
protein coding gene Chr5:71644197-71708734 (-)
CBA/J MGP_CBAJ_G0029285
protein coding gene Chr5:78063896-78130755 (-)
DBA/2J MGP_DBA2J_G0029432
protein coding gene Chr5:69973877-70035877 (-)
FVB/NJ MGP_FVBNJ_G0029392
protein coding gene Chr5:69149718-69206399 (-)
LP/J MGP_LPJ_G0029516
protein coding gene Chr5:73093286-73152351 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029418
protein coding gene Chr5:81422397-81481664 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030081
protein coding gene Chr5:71743858-71801980 (-)
PWK/PhJ MGP_PWKPhJ_G0028448
protein coding gene Chr5:68958813-69017937 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028281
protein coding gene Chr5:71079351-71136709 (-)
WSB/EiJ MGP_WSBEiJ_G0028806
protein coding gene Chr5:72026668-72089705 (-)



Homology
more
  • Human Ortholog
    TXK, TXK tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXK, TXK tyrosine kinase
  • Synonyms
    BTKL, PSCTK5, PTK4, RLK, TKL
  • Links
    NCBI Gene ID: 7294
    neXtProt AC: NX_P42681
    UniProt: P42681

  • Chr Location
    4p12; chr4:48066393-48134250 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased susceptibility to parasitic (Toxoplasma gondii) infection and decreased cytokine secretion in stimulated splenocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054892 Ensembl Gene Model | MGI Sequence Detail 56800 C57BL/6J ±  kb
transcript ENSMUST00000169534 Ensembl | MGI Sequence Detail 2344 Not Applicable  
polypeptide ENSMUSP00000129397 Ensembl | MGI Sequence Detail 527 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    Genomic 1
    cDNA 37
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-23796, MGI:2444219
References
more
  • Summaries
    All 79
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 40
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:294119 Shao B, et al., Th1 Cells Rolling on Selectins Trigger DAP12-Dependent Signals That Activate Integrin alphaLbeta2. J Immunol. 2020 Jan 1;204(1):37-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory