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Txk
Gene Detail
Symbol

Name
ID
Txk
TXK tyrosine kinase
MGI:102960
Synonyms
A130089B16Rik, Btkl, PTK4, Rlk
Feature Type
protein coding gene
Genetic Map
Chromosome 5
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:72695978-72752773 bp, - strand
From NCBI annotation of GRCm38

  56796 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Txk

Human
homologs
Human Homolog TXK, TXK tyrosine kinase
NCBI Gene ID 7294
neXtProt AC  NX_P42681
Human Synonyms  BTKL, PSCTK5, PTK4, RLK, TKL
Human Chr (Location)  4p12; chr4:48066393-48134256 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased susceptibility to parasitic (Toxoplasma gondii) infection and decreased cytokine secretion in stimulated splenocytes.
 
Interactions
Txk interacts with 98 markers (Mir23a, Mir23b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process activation of phospholipase C activity, adaptive immune response, ...
Component cytoplasm, extrinsic component of cytoplasmic side of plasma membrane, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (129)    Tissues (26)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 87
Northern blot 40
RT-PCR 2
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(36) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000054892 (Evidence)
Entrez Gene22165 (Evidence)
UniGene3264
DFCITC1582563, TC1598104, TC1716694
DoTSDT.101264197, DT.91338516, DT.91338514, DT.101328571, DT.488231, DT.101365216, DT.94133212, DT.91429333
EC2.7.10.2
Consensus CDS ProjectCCDS19334.1, CCDS51514.1
International Mouse Knockout Project StatusTxk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22165 NCBI Gene Model | MGI Sequence Detail 56796 C57BL/6J ±  kb
transcript NM_013698 RefSeq | MGI Sequence Detail 2344 C57BL/6 
polypeptide P42682 UniProt | EBI | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(527 from dbSNP Build 137)    SNPs within 2kb including multiple locations(533)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000016850 tyrosine-protein kinase TXK
Graphical View of Protein Domain Structure
References
(Earliest) J:22509 Hu Q, et al., Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J Biol Chem. 1995 Jan 27;270(4):1928-34
(Latest) J:184083 Qi Q, et al., A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. J Immunol. 2012 Apr 15;188(8):3611-9
All references(56)
Other
accession IDs
MGD-MRK-23796, MGI:2444219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory