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Txk Gene Detail
Summary
  • Symbol
    Txk
  • Name
    TXK tyrosine kinase
  • Synonyms
    A130089B16Rik, Btkl, PTK4, Rlk
  • Feature Type
    protein coding gene
  • IDs
    MGI:102960
    NCBI Gene: 22165
  • Gene Overview
    MyGene.info: TXK
Location & Maps
more
  • Sequence Map
    Chr5:72695978-72752777 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56800 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TXK, TXK tyrosine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TXK, TXK tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTKL, PSCTK5, PTK4, RLK, TKL
  • Links
    NCBI Gene ID: 7294
    neXtProt AC: NX_P42681

  • Chr Location
    4p12; chr4:48066393-48134256 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Txk
  • Incidental Mutations
Homozygous mutation of this gene results in increased susceptibility to parasitic (Toxoplasma gondii) infection and decreased cytokine secretion in stimulated splenocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054700 VEGA Gene Model | MGI Sequence Detail 56800 C57BL/6J ±  kb
transcript OTTMUST00000135585 VEGA | MGI Sequence Detail 2260 Not Applicable  
polypeptide OTTMUSP00000071727 VEGA | MGI Sequence Detail 527 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    527 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 39
    Genomic 1
    cDNA 36
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-23796, MGI:2444219
References
more
  • Summaries
    All 54
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 36
  • Earliest
    J:22509 Hu Q, et al., Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J Biol Chem. 1995 Jan 27;270(4):1928-34
  • Latest
    J:184083 Qi Q, et al., A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. J Immunol. 2012 Apr 15;188(8):3611-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory