About   Help   FAQ
Adcy7
Gene Detail
Symbol

Name
ID
Adcy7
adenylate cyclase 7
MGI:102891
Feature Type
protein coding gene
Genetic Map
Chromosome 8
43.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:88272403-88329962 bp, + strand
From Ensembl annotation of GRCm38

  57560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADCY7
Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy7

Human
homologs
ADCY7, adenylate cyclase 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 113
neXtProt AC: NX_P51828

Human Synonyms: AC7

Human Chr (Location): 16q12.1; chr16:50244749-50318135 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display some degree of pre- or postnatal lethality. Surviving adults for one allele appear to be normal. Heterozygous females for one allele display decreased depression related behaviors.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Adcy7 interacts with 322 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process activation of adenylate cyclase activity, cAMP biosynthetic process, ...
Component integral component of membrane, membrane, ...
Function adenylate cyclase activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (332)    Tissues (167)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 244
In situ reporter (knock in) 30
Northern blot 20
RT-PCR 38
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adcy7    NEW 
Molecular
reagents
All nucleic(22) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000031659 (Evidence)
Entrez Gene 11513 (Evidence)
DFCI TC1680150, TC1674277, TC1665009, TC1576155, TC1688875
DoTS DT.101388675, DT.94150746, DT.493263, DT.110875084, DT.97366677, DT.97366678
NIA Mouse Gene Index U042919
EC 4.6.1.1
Consensus CDS Project CCDS22509.1
International Mouse Phenotyping Consortium Status Adcy7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031659 Ensembl Gene Model | MGI Sequence Detail 57560 C57BL/6J ±  kb
transcript ENSMUST00000169037 Ensembl | MGI Sequence Detail 6121 Not Applicable 
polypeptide ENSMUSP00000130594 Ensembl | MGI Sequence Detail 1099 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(26) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(731 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009398 Adenylate cyclase-like
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003758 adenylate cyclase type 7
References
(Earliest) J:21500 Watson PA, et al., Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. J Biol Chem. 1994 Nov 18;269(46):28893-8
(Latest) J:191067 Jiang LI, et al., Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation. Mol Immunol. 2013 May;54(1):14-22
All references(39)
Other
accession IDs
MGD-MRK-23725, MGI:2142399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory