Adcy7
Gene Detail

Symbol Name ID

Adcy7 adenylate cyclase 7 MGI:102891

Feature Type

protein coding gene

Genetic Map

Chromosome 8

43.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:88272403-88329962 bp, + strand From NCBI annotation of GRCm38   57560 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Adcy7 ± 2 cM)

Gene Tree: Adcy7

Human ortholog

ADCY7 adenylate cyclase 7 NCBI Gene ID 113
Human Synonyms: AC7
Human Chr16:50321823-50352043 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene display some degree of pre- or postnatal lethality. Surviving adults for one allele appear to be normal. Heterozygous females for one allele display decreased depression related behaviors.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	activation of adenylate cyclase activity, cAMP biosynthetic process, ...
Component	integral to membrane, membrane, ...
Function	adenylate cyclase activity, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (332)    Tissues (168)    Images (26)
Theiler Stages: 22, 23, 24, 28

Assay Type	Results
RNA in situ	244
In situ reporter (knock in)	30
Northern blot	20
RT-PCR	38

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000031659 (Evidence)
Entrez Gene	11513 (Evidence)
DFCI	TC1576155, TC1665009, TC1674277, TC1680150, TC1688875
DoTS	DT.101388675, DT.110875084, DT.493263, DT.94150746, DT.97366677, DT.97366678
NIA Mouse Gene Index	U042919
EC	4.6.1.1
Consensus CDS Project	CCDS22509.1
International Mouse Knockout Project Status	Adcy7

Sequences

Length	Strain/Species
genomic	11513	NCBI Gene Model | MGI Sequence Detail	57560	C57BL/6J
transcript	NM_007406	RefSeq | MGI Sequence Detail	6121	C57BL/6
polypeptide	P51829	UniProt | EBI | MGI Sequence Detail	1099	Not Applicable

All sequences(49) RefSeq(8) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(376 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009398	Adenylate cyclase-like
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology	PR:000003758	adenylate cyclase type 7

Graphical View of Protein Domain Structure

References

(Earliest) J:21500 Watson PA, et al., Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. J Biol Chem. 1994 Nov 18;269(46):28893-8
(Latest) J:191067 Jiang LI, et al., Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation. Mol Immunol. 2013 May;54(1):14-22
All references(41)

Other accession IDs

MGD-MRK-23725, MGI:2142399