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Adcy7
Gene Detail
Symbol

Name
ID
Adcy7
adenylate cyclase 7
MGI:102891
Feature Type
protein coding gene
Genetic Map
Chromosome 8
43.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:88272403-88329962 bp, + strand
From NCBI annotation of GRCm38

  57560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy7

Human
homologs
Human Homolog ADCY7, adenylate cyclase 7
NCBI Gene ID 113
neXtProt AC  NX_P51828
Human Synonyms  AC7
Human Chr (Location)  16q12.1; chr16:50244919-50318135 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display some degree of pre- or postnatal lethality. Surviving adults for one allele appear to be normal. Heterozygous females for one allele display decreased depression related behaviors.
 
Interactions
Adcy7 interacts with 323 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process activation of adenylate cyclase activity, cAMP biosynthetic process, ...
Component integral component of membrane, membrane, ...
Function adenylate cyclase activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (332)    Tissues (167)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 244
In situ reporter (knock in) 30
Northern blot 20
RT-PCR 38
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000031659 (Evidence)
Entrez Gene11513 (Evidence)
DFCITC1576155, TC1665009, TC1674277, TC1680150, TC1688875
DoTSDT.101388675, DT.110875084, DT.493263, DT.94150746, DT.97366677, DT.97366678
NIA Mouse Gene IndexU042919
EC4.6.1.1
Consensus CDS ProjectCCDS22509.1
International Mouse Knockout Project StatusAdcy7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11513 NCBI Gene Model | MGI Sequence Detail 57560 C57BL/6J ±  kb
transcript NM_007406 RefSeq | MGI Sequence Detail 6121 C57BL/6 
polypeptide P51829 UniProt | EBI | MGI Sequence Detail 1099 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(16) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(731 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009398 Adenylate cyclase-like
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003758 adenylate cyclase type 7
Graphical View of Protein Domain Structure
References
(Earliest) J:21500 Watson PA, et al., Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. J Biol Chem. 1994 Nov 18;269(46):28893-8
(Latest) J:191067 Jiang LI, et al., Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation. Mol Immunol. 2013 May;54(1):14-22
All references(41)
Other
accession IDs
MGD-MRK-23725, MGI:2142399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory