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Fosl2
Gene Detail
Symbol

Name
ID
Fosl2
fos-like antigen 2
MGI:102858
Synonyms
Fra-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:32135801-32157842 bp, + strand
From VEGA annotation of GRCm38

  22042 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3845  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOSL2
Protein SuperFamily: fos transforming protein
Gene Tree: Fosl2

Human
homologs
FOSL2, FOS-like antigen 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2355
neXtProt AC: NX_P15408

Human Synonyms: FRA2

Human Chr (Location): 2p23.3; chr2:28392759-28417312 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Radiation induced(3) Targeted(7) Transgenic(1)
Genomic Mutations involving Fosl2 (4)
 
Mice homozygous for disruptions in this gene die within one week after birth and show postnatal growth retardation. Further analysis of one allele showed abnormal cartilage development, with delayed bone ossification and impaired chondrocyte differentiation.
 
Human Diseases Modeled in Mice Using Fosl2 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(4)
Interactions
Fosl2 interacts with 436 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process keratinocyte development, positive regulation of fibroblast proliferation, ...
Component nucleoplasm, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (201)    Tissues (82)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
RT-PCR 8
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FOSL2 ; Xenbase fosl2    NEW 
Molecular
reagents
All nucleic(25) Genomic(9) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000055218 (Evidence)
Ensembl Gene Model ENSMUSG00000029135 (Evidence)
Entrez Gene 14284 (Evidence)
DFCI TC1580363, TC1607358, TC1620210
DoTS DT.101139041, DT.481349, DT.522639
NIA Mouse Gene Index U005456
Consensus CDS Project CCDS19190.1
International Mouse Phenotyping Consortium Status Fosl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055218 VEGA Gene Model | MGI Sequence Detail 22042 C57BL/6J ±  kb
transcript OTTMUST00000136748 VEGA | MGI Sequence Detail 6537 Not Applicable 
polypeptide OTTMUSP00000072135 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000837 AP-1 transcription factor
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR029814 Fos-related antigen 2
Protein Ontology PR:000007600 fos-related antigen 2
References
(Earliest) J:21147 Foletta VC, et al., Cloning and characterisation of the mouse fra-2 gene. Oncogene. 1994 Nov;9(11):3305-11
(Latest) J:218234 Wurm S, et al., Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 2015 Jan 15;29(2):144-56
All references(47)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-23691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory