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Fosl2
Gene Detail
 Symbol
Name
ID
Fosl2
fos-like antigen 2
MGI:102858
Synonyms Fra-2
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:32136472-32157831 bp, + strand
From Ensembl annotation of GRCm38

  21360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3845  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fos transforming protein
Gene Tree: Fosl2

Human
homologs
Human Homolog FOSL2, FOS-like antigen 2
NCBI Gene ID 2355
neXtProt AC  NX_P15408
Human Synonyms  FRA2
Human Chr (Location)  2p23.3; chr2:28392837-28417312 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Radiation induced(2) Targeted(5)
Genomic Mutations involving Fosl2 (3)
 
Mice homozygous for disruptions in this gene die within one week after birth and show postnatal growth retardation. Further analysis of one allele showed abnormal cartilage development, with delayed bone ossification and impaired chondrocyte differentiation.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Fosl2 interacts with 436 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process positive regulation of fibroblast proliferation, positive regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (208)    Tissues (87)    Images (30)
Theiler Stages: 2, 3, 4, 5, 16, 17, 18, 19, 21, 23, 28
Assay TypeResults
RNA in situ 193
RT-PCR 15
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(9) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000029135 (Evidence)
Entrez Gene14284 (Evidence)
DFCITC1580363, TC1607358, TC1620210
DoTSDT.101139041, DT.481349, DT.522639
NIA Mouse Gene IndexU005456
Consensus CDS ProjectCCDS19190.1
International Mouse Knockout Project StatusFosl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029135 Ensembl Gene Model | MGI Sequence Detail 21360 C57BL/6J ±  kb
transcript ENSMUST00000031017 Ensembl | MGI Sequence Detail 5855 Not Applicable 
polypeptide ENSMUSP00000031017 Ensembl | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR000837 Fos transforming protein
Protein Ontology PR:000007600 fos-related antigen 2
References (Earliest) J:21147 Foletta VC, et al., Cloning and characterisation of the mouse fra-2 gene. Oncogene. 1994 Nov;9(11):3305-11
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(43)
Other
accession IDs
MGD-MRK-23691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory