About   Help   FAQ
Serpina3c
Gene Detail
 Symbol
Name
ID
Serpina3c
serine (or cysteine) peptidase inhibitor, clade A, member 3C
MGI:102848
Synonyms 1A1, alpha-1 antiproteinase, Kalbp, Klkbp
Feature Type protein coding gene
Genetic Map
Chromosome 12
53.46 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:104146382-104153870 bp, - strand
From VEGA annotation of GRCm38

  7489 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111129  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 6 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpina3c

Human
homologs
Human Homolog SERPINA3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Gene ID 12
neXtProt AC  NX_P01011
Human Synonyms  AACT, ACT, GIG25
Human Chr (Location)  14q32.1; chr14:94612377-94624053 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Serpina3c interacts with 129 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component blood microparticle, extracellular region, ...
Function peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (1)    Images (3)
Theiler Stages: 23
Assay TypeResults
RNA in situ 3
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(2) cDNA(7)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027583 (Evidence)
Ensembl Gene ModelENSMUSG00000066361 (Evidence)
Entrez Gene16625 (Evidence)
UniGene422814
DFCITC1589989
DoTSDT.91491101
NIA Mouse Gene IndexU034304
Consensus CDS ProjectCCDS26148.1
International Mouse Knockout Project StatusSerpina3c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027583 VEGA Gene Model | MGI Sequence Detail 7489 C57BL/6J ±  kb
transcript OTTMUST00000068294 VEGA | MGI Sequence Detail 2213 Not Applicable 
polypeptide OTTMUSP00000034490 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000015935 serine protease inhibitor A3C
References (Earliest) J:1851 Chai KX, et al., Molecular cloning and sequence analysis of the mouse kallikrein-binding protein gene. Biochim Biophys Acta. 1991 Dec 2;1129(1):127-30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGD-MRK-11551, MGD-MRK-23681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory