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Bdkrb2 Gene Detail
Summary
  • Symbol
    Bdkrb2
  • Name
    bradykinin receptor, beta 2
  • Synonyms
    B2, B(2), B2R, BK2R, kinin B2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102845
    NCBI Gene: 12062
  • Gene Overview
    MyGene.info: BDKRB2
Location & Maps
more
  • Sequence Map
    Chr12:105563172-105593071 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29900 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 55.76 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BDKRB2, bradykinin receptor B2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BDKRB2, bradykinin receptor B2
    Orthology source: HomoloGene
  • Synonyms
    B2R, BK2, BK-2, BKR2, BRB2
  • Links
    NCBI Gene ID: 624
    neXtProt AC: NX_P30411

  • Chr Location
    14q32.2; chr14:96204798-96244329 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    25 phenotypes from multigenic genotypes
    1 images
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Bdkrb2
  • Incidental Mutations
Homozygous null mutants are indistinguishable from normal littermates, but bradykinin response is eliminated in ileum, uterus, and cervical ganglia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021070 Ensembl Gene Model | MGI Sequence Detail 29900 C57BL/6J ±  kb
transcript ENSMUST00000001652 Ensembl | MGI Sequence Detail 1680 Not Applicable  
polypeptide ENSMUSP00000001652 Ensembl | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    214 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001172 B2 bradykinin receptor
  • InterPro Domains
    IPR001504 Bradykinin receptor B2
    IPR000496 Bradykinin receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 25
    Genomic 10
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-19754
References
more
  • Summaries
    All 121
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 81
  • Earliest
    J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
  • Latest
    J:226441 Nickel KF, et al., The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis. Blood. 2015 Sep 10;126(11):1379-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory