About   Help   FAQ
Bdkrb2
Gene Detail
Symbol

Name
ID
Bdkrb2
bradykinin receptor, beta 2
MGI:102845
Synonyms
B2, B(2), B2R, BK2R, kinin B2
Feature Type
protein coding gene
Genetic Map
Chromosome 12
55.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:105563172-105593071 bp, + strand
From Ensembl annotation of GRCm38

  29900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:519  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bradykinin receptor
Gene Tree: Bdkrb2

Human
homologs
Human Homolog BDKRB2, bradykinin receptor B2
NCBI Gene ID 624
neXtProt AC  NX_P30411
Human Synonyms  B2R, BK2, BK-2, BKR2, BRB2
Human Chr (Location)  14q32.1-q32.2; chr14:96204798-96244329 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Genomic Mutations involving Bdkrb2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are indistinguishable from normal littermates, but bradykinin response is eliminated in ileum, uterus, and cervical ganglia.
 
Phenotype Images(1)
Interactions
Bdkrb2 interacts with 49 markers (Mir10a, Mir10b, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process acute inflammatory response to antigenic stimulus, arachidonic acid secretion, ...
Component cytosol, endosome, ...
Function beta-2 adrenergic receptor binding, bradykinin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(10) cDNA(12) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021070 (Evidence)
Entrez Gene12062 (Evidence)
UniGene390475
DFCITC1591564
DoTSDT.87038645
NIA Mouse Gene IndexU014344
Consensus CDS ProjectCCDS49160.1
International Mouse Knockout Project StatusBdkrb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021070 Ensembl Gene Model | MGI Sequence Detail 29900 C57BL/6J ±  kb
transcript ENSMUST00000001652 Ensembl | MGI Sequence Detail 1680 Not Applicable 
polypeptide ENSMUSP00000001652 Ensembl | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001504 Bradykinin receptor B2
InterPro IPR000496 Bradykinin receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001172 B2 bradykinin receptor
References
(Earliest) J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
(Latest) J:209809 Diehl SA, et al., G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun. 2014 Feb;82(2):773-82
All references(124)
Other
accession IDs
MGD-MRK-19754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory