About   Help   FAQ
Acsl1 Gene Detail
Summary
  • Symbol
    Acsl1
  • Name
    acyl-CoA synthetase long-chain family member 1
  • Synonyms
    Acas1, Facl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102797
    NCBI Gene: 14081
  • Gene Overview
    MyGene.info: ACSL1
  • Alliance
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:46471037-46536051 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 26.36 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    428 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102797
protein coding gene Chr8:46471037-46536051 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033588
protein coding gene Chr8:45575162-45639653 (+)
A/J MGP_AJ_G0033570
protein coding gene Chr8:43810505-43887290 (+)
AKR/J MGP_AKRJ_G0033495
protein coding gene Chr8:45105487-45173458 (+)
BALB/cJ MGP_BALBcJ_G0033567
protein coding gene Chr8:43993956-44059496 (+)
C3H/HeJ MGP_C3HHeJ_G0033276
protein coding gene Chr8:45631798-45701399 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034083
protein coding gene Chr8:47299711-47371100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031032
protein coding gene Chr8:40067991-40131954 (+)
CAST/EiJ MGP_CASTEiJ_G0032602
protein coding gene Chr8:45064093-45131327 (+)
CBA/J MGP_CBAJ_G0033255
protein coding gene Chr8:49188696-49257244 (+)
DBA/2J MGP_DBA2J_G0033408
protein coding gene Chr8:43620076-43684930 (+)
FVB/NJ MGP_FVBNJ_G0033349
protein coding gene Chr8:43094067-43160156 (+)
LP/J MGP_LPJ_G0033496
protein coding gene Chr8:45584227-45652354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033394
protein coding gene Chr8:49285994-49358332 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034101
protein coding gene Chr8:45261574-45328001 (+)
PWK/PhJ MGP_PWKPhJ_G0032310
protein coding gene Chr8:43140823-43206834 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032146
protein coding gene Chr8:44422601-44493542 (+)
WSB/EiJ MGP_WSBEiJ_G0032718
protein coding gene Chr8:45517199-45588696 (+)



Homology
more
  • Human Ortholog
    ACSL1, acyl-CoA synthetase long chain family member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACSL1, acyl-CoA synthetase long chain family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACS1, FACL1, FACL2, LACS, LACS1, LACS2
  • Links
    NCBI Gene ID: 2180
    neXtProt AC: NX_P33121
    UniProt: P33121

  • Chr Location
    4q35.1; chr4:184755595-184826593 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Acsl1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Liver acyl-CoA levels are reduced when this gene is conditionally knocked out in the liver. Impaired adaptive thermogenesis when this gene is conditionally knocked out in adipose tissue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14081 NCBI Gene Model | MGI Sequence Detail 65015 C57BL/6J ±  kb
    transcript NM_001302163 RefSeq | MGI Sequence Detail 3927 C57BL/6  
    polypeptide P41216 UniProt | EBI | MGI Sequence Detail 699 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 190
      cDNA 186
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1026, MGD-MRK-19705, MGI:87869
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:2016 Weiner FR, et al., Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. J Biol Chem. 1991 Dec 15;266(35):23525-8
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2018;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory