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Acsl1 Gene Detail
Summary
  • Symbol
    Acsl1
  • Name
    acyl-CoA synthetase long-chain family member 1
  • Synonyms
    Acas1, Facl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102797
    NCBI Gene: 14081
  • Gene Overview
    MyGene.info: ACSL1
Location & Maps
more
  • Sequence Map
    Chr8:46471041-46536051 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65011 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 26.36 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACSL1, acyl-CoA synthetase long-chain family member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACSL1, acyl-CoA synthetase long-chain family member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACS1, FACL1, FACL2, LACS, LACS1, LACS2
  • Links
    NCBI Gene ID: 2180
    neXtProt AC: NX_P33121

  • Chr Location
    4q35.1; chr4:184755595-184826114 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    2
  • Transgenic
    3
  • Genomic Mutations
    1 involving Acsl1
  • Incidental Mutations
Liver acyl-CoA levels are reduced when this gene is conditionally knocked out in the liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022668 VEGA Gene Model | MGI Sequence Detail 65011 C57BL/6J ±  kb
transcript OTTMUST00000054312 VEGA | MGI Sequence Detail 3893 Not Applicable  
polypeptide OTTMUSP00000025909 VEGA | MGI Sequence Detail 699 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    428 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 188
    cDNA 185
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-1026, MGD-MRK-19705, MGI:87869
References
more
  • Summaries
    All 49
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:2016 Weiner FR, et al., Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. J Biol Chem. 1991 Dec 15;266(35):23525-8
  • Latest
    J:230606 Grevengoed TJ, et al., Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation. FASEB J. 2015 Nov;29(11):4641-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory