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Acsl1 Gene Detail
Summary
  • Symbol
    Acsl1
  • Name
    acyl-CoA synthetase long-chain family member 1
  • Synonyms
    Acas1, Facl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102797
    NCBI Gene: 14081
  • Gene Overview
    MyGene.info: ACSL1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:46471037-46536051 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65015 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 26.36 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACSL1, acyl-CoA synthetase long chain family member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACSL1, acyl-CoA synthetase long chain family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACS1, FACL1, FACL2, LACS, LACS1, LACS2
  • Links
    NCBI Gene ID: 2180
    neXtProt AC: NX_P33121
    UniProt: P33121

  • Chr Location
    4q35.1; chr4:184755595-184826593 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Acsl1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 4 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Liver acyl-CoA levels are reduced when this gene is conditionally knocked out in the liver. Impaired adaptive thermogenesis when this gene is conditionally knocked out in adipose tissue.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022668 VEGA Gene Model | MGI Sequence Detail 65015 C57BL/6J ±  kb
    transcript OTTMUST00000054312 VEGA | MGI Sequence Detail 3897 Not Applicable  
    polypeptide OTTMUSP00000025909 VEGA | MGI Sequence Detail 699 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      428 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 185
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1026, MGD-MRK-19705, MGI:87869
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:2016 Weiner FR, et al., Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. J Biol Chem. 1991 Dec 15;266(35):23525-8
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2017;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory