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Guca1a
Gene Detail
 Symbol
Name
ID
Guca1a
guanylate cyclase activator 1a (retina)
MGI:102770
Synonyms Guca1, mGCAP1
Feature Type protein coding gene
Genetic Map
Chromosome 17
23.07 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:47394560-47400584 bp, - strand
From Ensembl annotation of GRCm38

  6025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Guca1a

Human
homologs
Human Homolog GUCA1A, guanylate cyclase activator 1A (retina)
NCBI Gene ID 2978
neXtProt AC  NX_P43080
Human Synonyms  C6orf131, COD3, CORD14, dJ139D8.6, GCAP, GCAP1, GUCA, GUCA1
Human Chr (Location)  6p21.1; chr6:42155406-42180056 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GUCA1A
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice heterozygous or homozygous for a knock-in allele exhibit photoreceptor degeneration and loss of cone and rod function.
 
Human Diseases Modeled Using Mouse Guca1a (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process phototransduction, positive regulation of cGMP biosynthetic process, ...
Component membrane, photoreceptor inner segment, ...
Function calcium ion binding, calcium sensitive guanylate cyclase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (43)    Tissues (36)    Images (30)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 43
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(39) Genomic(6) cDNA(33)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023982 (Evidence)
Entrez Gene14913 (Evidence)
UniGene16224
DFCITC1584035
DoTSDT.50315624
NIA Mouse Gene IndexU037881
Consensus CDS ProjectCCDS28848.1
International Mouse Knockout Project StatusGuca1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023982 Ensembl Gene Model | MGI Sequence Detail 6025 C57BL/6J ±  kb
transcript ENSMUST00000059348 Ensembl | MGI Sequence Detail 871 Not Applicable 
polypeptide ENSMUSP00000060027 Ensembl | MGI Sequence Detail 202 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001125 Recoverin
Protein Ontology PR:000008343 guanylyl cyclase-activating protein 1
References (Earliest) J:19567 Subbaraya I, et al., Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 1994 Dec 9;269(49):31080-9
(Latest) J:202969 Reingruber J, et al., Detection of single photons by toad and mouse rods. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19378-83
All references(51)
Other
accession IDs
MGD-MRK-19677

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory