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Guca1a
Gene Detail
Symbol

Name
ID
Guca1a
guanylate cyclase activator 1a (retina)
MGI:102770
Synonyms
Guca1, mGCAP1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
23.07 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:47394560-47400584 bp, - strand
From Ensembl annotation of GRCm38

  6025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Guca1a

Human
homologs
Human Homolog GUCA1A, guanylate cyclase activator 1A (retina)
NCBI Gene ID 2978
neXtProt AC  NX_P43080
Human Synonyms  C6orf131, COD3, CORD14, dJ139D8.6, GCAP, GCAP1, GUCA, GUCA1
Human Chr (Location)  6p21.1; chr6:42155406-42180056 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GUCA1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Mice heterozygous or homozygous for a knock-in allele exhibit photoreceptor degeneration and loss of cone and rod function.
 
Human Diseases Modeled Using Mouse Guca1a (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Guca1a interacts with 5 markers (Mir152, Mir379, Mir411, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (53)    Tissues (40)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RT-PCR 10
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(6) cDNA(33) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023982 (Evidence)
Entrez Gene14913 (Evidence)
UniGene16224
DFCITC1584035
DoTSDT.50315624
NIA Mouse Gene IndexU037881
Consensus CDS ProjectCCDS28848.1
International Mouse Knockout Project StatusGuca1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023982 Ensembl Gene Model | MGI Sequence Detail 6025 C57BL/6J ±  kb
transcript ENSMUST00000059348 Ensembl | MGI Sequence Detail 871 Not Applicable 
polypeptide ENSMUSP00000060027 Ensembl | MGI Sequence Detail 202 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000008343 guanylyl cyclase-activating protein 1
References
(Earliest) J:19567 Subbaraya I, et al., Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 1994 Dec 9;269(49):31080-9
(Latest) J:210433 Mandal NA, et al., Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene. Exp Eye Res. 2013 Jan;106:24-33
All references(53)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19677

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory