Guca1a
Gene Detail

Symbol Name ID

Guca1a guanylate cyclase activator 1a (retina) MGI:102770

Synonyms

Guca1, mGCAP1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

23.07 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:47394560-47400584 bp, - strand From Ensembl annotation of GRCm38   6025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Guca1a

Human homologs

Human Homolog		GUCA1A, guanylate cyclase activator 1A (retina)
NCBI Gene ID		2978
neXtProt AC		NX_P43080
Human Synonyms		C6orf131, COD3, CORD14, dJ139D8.6, GCAP, GCAP1, GUCA, GUCA1
Human Chr (Location)		6p21.1; chr6:42123144-42147794 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GUCA1A

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice heterozygous or homozygous for a knock-in allele exhibit photoreceptor degeneration and loss of cone and rod function.

 
Human Diseases Modeled Using Mouse Guca1a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	phototransduction, positive regulation of cGMP biosynthetic process, ...
Component	membrane, photoreceptor inner segment, ...
Function	calcium ion binding, calcium sensitive guanylate cyclase activator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (43)    Tissues (36)    Images (30)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	43

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) Genomic(6) cDNA(33)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023982 (Evidence)
Entrez Gene	14913 (Evidence)
UniGene	16224
DFCI	TC1584035
DoTS	DT.50315624
NIA Mouse Gene Index	U037881
Consensus CDS Project	CCDS28848.1
International Mouse Knockout Project Status	Guca1a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023982	Ensembl Gene Model | MGI Sequence Detail	6025	C57BL/6J
transcript	ENSMUST00000059348	Ensembl | MGI Sequence Detail	871	Not Applicable
polypeptide	ENSMUSP00000060027	Ensembl | MGI Sequence Detail	202	Not Applicable

All sequences(13) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	Calcium-binding EF-hand
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR001125	Recoverin
Protein Ontology	PR:000008343	guanylyl cyclase-activating protein 1

References

(Earliest) J:19567 Subbaraya I, et al., Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 1994 Dec 9;269(49):31080-9
(Latest) J:192199 Makino CL, et al., Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. PLoS One. 2012;7(10):e47637
All references(47)

Other accession IDs

MGD-MRK-19677