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Symbol
Name
ID

Guca1a
guanylate cyclase activator 1a (retina)
MGI:102770

Phenotype annotations related to vision/eye

Darker colors indicate more annotations

Human Phenotypes	Macular atrophy	Cone/cone-rod dystrophy	Photophobia	Reduced visual acuity	Progressive visual loss
Disease(s) Associated with GUCA1A
cone-rod dystrophy 14

Mouse Phenotypes

decreased retina photoreceptor cell number

decreased retina cone cell number

abnormal photoreceptor outer segment morphology

short photoreceptor outer segment

retina photoreceptor degeneration

abnormal retina morphology

thin retina outer nuclear layer

decreased a-wave amplitude

decreased b-wave amplitude

abnormal eye electrophysiology

abnormal cone electrophysiology

abnormal rod electrophysiology

decreased visual acuity

Availability

Mouse Genotype

Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc

Guca1a^tm1.1Hunt/Guca1a^tm1.1Hunt

Guca1a^tm1Itl/Guca1a^tm1Itl

Guca1a/Guca1b^tm1Jnc/Guca1a⁺

Guca1a^tm1.1Hunt/Guca1a⁺

Tg(Guca1a*L151F)#Wbae/0

Tg(Guca1a*L151F/EGFP)#Wbae/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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