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Trim25
Gene Detail
Symbol

Name
ID
Trim25
tripartite motif-containing 25
MGI:102749
Synonyms
estrogen-responsive finger protein, Zfp147
Feature Type
protein coding gene
Genetic Map
Chromosome 11
54.34 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:88999376-89020293 bp, + strand
From VEGA annotation of GRCm38

  20918 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TRIM25
Protein SuperFamily: tripartite motif-containing protein
Gene Tree: Trim25

Human
homologs
TRIM25, tripartite motif containing 25
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7706
neXtProt AC: NX_Q14258

Human Synonyms: EFP, RNF147, Z147, ZNF147

Human Chr (Location): 17q23.2; chr17:56887909-56914048 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(9) Targeted(8)
Genomic Mutations involving Trim25 (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Engineered mutations result in a compromised response to estrogen resulting in functional but small uteri.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Trim25 interacts with 356 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process defense response to virus, ERAD pathway, ...
Component cytoplasm, nucleoplasm
Function ligase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (337)    Tissues (214)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 328
RT-PCR 9
cDNA source data(101)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trim25 ; ZFIN trim25    NEW 
Molecular
reagents
All nucleic(107) Genomic(2) cDNA(101) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000001304 (Evidence)
Ensembl Gene Model ENSMUSG00000000275 (Evidence)
Entrez Gene 217069 (Evidence)
UniGene 248445
DFCI TC1579678, TC1583603, TC1598209, TC1631839
DoTS DT.101133152, DT.101353799, DT.101397714, DT.101397715, DT.87072499, DT.91376815, DT.97359373
NIA Mouse Gene Index U013176
EC 6.3.2.19, 6.3.2.n3
PDB 4B8E
Consensus CDS Project CCDS36278.1
International Mouse Phenotyping Consortium Status Trim25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001304 VEGA Gene Model | MGI Sequence Detail 20918 C57BL/6J ±  kb
transcript OTTMUST00000002622 VEGA | MGI Sequence Detail 5590 Not Applicable 
polypeptide OTTMUSP00000001297 VEGA | MGI Sequence Detail 634 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(9)
Polymorphisms
SNPs within 2kb(296 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR000315 B-box-type zinc finger
InterPro IPR003879 Butyrophylin-like
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR006574 SPRY-associated
InterPro IPR003877 SPRY domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016650 E3 ubiquitin/ISG15 ligase TRIM25
References
(Earliest) J:25026 Inoue S, et al., Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11117-21
(Latest) J:203808 D'Cruz AA, et al., Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling. Biochem J. 2013 Dec 1;456(2):231-40
All references(46)
Other
accession IDs
MGD-MRK-19654, MGI:2144055, MGI:2144339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory