Ednrb
Gene Detail

Symbol Name ID

Ednrb endothelin receptor type B MGI:102720

Synonyms

ETb, ETR-b, Sox10m1

Feature Type

protein coding gene

Genetic Map

Chromosome 14

53.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)

Sequence Map

Chr14:103814625-103844173 bp, - strand From NCBI annotation of GRCm38   29549 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ednrb ± 2 cM)

Protein SuperFamily: endothelin receptor
Gene Tree: Ednrb

Human ortholog

EDNRB endothelin receptor type B NCBI Gene ID 1910
Human Synonyms: ABCDS, ETB, ET-B, ETBR, ET-BR, ETRB, HSCR, HSCR2, WS4A
Human Chr13:78469616-78492966 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human EDNRB (3)

Alleles and phenotypes

All alleles(45) : Targeted(10) Spontaneous(3) Chemically induced(14) Radiation induced(20)
 

Homozygotes for null mutations have pigmentation limited to small patches on the head and rump, exhibit abnormal neural epithelium of the inner ear, and die from megacolon resulting from impaired neuronal migration and aganglia.

 
Human Diseases Modeled Using Mouse Ednrb (3)    Alleles Annotated to Human Diseases(3)    Phenotype Images(8)

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	cGMP-mediated signaling, developmental pigmentation, ...
Component	integral to membrane, membrane, ...
Function	endothelin receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (663)    Tissues (119)    Images (81)
Theiler Stages: 11, 18, 19, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	633
Northern blot	14
RT-PCR	16

cDNA source data(130)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(133) Genomic(1) cDNA(130) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000022122 (Evidence)
Entrez Gene	13618 (Evidence)
UniGene	229532
DoTS	DT.101129975, DT.101212651, DT.101375465, DT.110767026, DT.40167075, DT.94152189, DT.94215927, DT.97408483
Consensus CDS Project	CCDS27317.1
International Mouse Knockout Project Status	Ednrb

Sequences

Length	Strain/Species
genomic	13618	NCBI Gene Model | MGI Sequence Detail	29549	C57BL/6J
transcript	NM_001136061	RefSeq | MGI Sequence Detail	4191	C57BL/6
polypeptide	P48302	UniProt | EBI | MGI Sequence Detail	442	Not Applicable

All sequences(117) RefSeq(6) UniProt(2)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(84 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001112	Endothelin B receptor
InterPro	IPR000499	Endothelin receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001222	endothelin receptor B

Graphical View of Protein Domain Structure

References

(Earliest) J:23183 Dunn LC, Types of white spotting in mice. Am Naturalist. 1920 Nov-Dec;54:465-95
(Latest) J:193523 Dang R, et al., Anatomic modifications in the enteric nervous system of JF1 mice with the classic piebald mutation. J Vet Med Sci. 2012 Mar;74(3):391-4
All references(177)

Other accession IDs

MGD-MRK-14268, MGD-MRK-19624, MGI:2145744