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Ednrb
Gene Detail
 Symbol
Name
ID
Ednrb
endothelin receptor type B
MGI:102720
Synonyms ETb, ETR-b, Sox10m1
Feature Type protein coding gene
Genetic Map
Chromosome 14
53.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr14:103814625-103844173 bp, - strand
From NCBI annotation of GRCm38

  29549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:89  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: endothelin receptor
Gene Tree: Ednrb

Human
homologs
Human Homolog EDNRB, endothelin receptor type B
NCBI Gene ID 1910
neXtProt AC  NX_P24530
Human Synonyms  ABCDS, ETB, ET-B, ETBR, ET-BR, ETRB, HSCR, HSCR2, WS4A
Human Chr (Location)  13q22; chr13:77895481-77975529 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human EDNRB
Mutations,
alleles, and
phenotypes
All mutations/alleles(48) : Chemically and radiation induced(2) Chemically induced (ENU)(2) Chemically induced (other)(11) Radiation induced(18) Spontaneous(4) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations have pigmentation limited to small patches on the head and rump, exhibit abnormal neural epithelium of the inner ear, and die from megacolon resulting from impaired neuronal migration and aganglia.
 
Human Diseases Modeled Using Mouse Ednrb (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(9)
Interactions
Ednrb interacts with 282 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process cGMP-mediated signaling, developmental pigmentation, ...
Component integral component of membrane, membrane, ...
Function endothelin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (770)    Tissues (167)    Images (115)
Theiler Stages: 11, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 633
In situ reporter (knock in) 107
Northern blot 14
RT-PCR 16
cDNA source data(121)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) Genomic(1) cDNA(121) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022122 (Evidence)
Entrez Gene13618 (Evidence)
UniGene229532
DoTSDT.101129975, DT.101212651, DT.101375465, DT.110767026, DT.40167075, DT.94152189, DT.94215927, DT.97408483
Consensus CDS ProjectCCDS27317.1
International Mouse Knockout Project StatusEdnrb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13618 NCBI Gene Model | MGI Sequence Detail 29549 C57BL/6J ±  kb
transcript NM_001136061 RefSeq | MGI Sequence Detail 4191 C57BL/6 
polypeptide P48302 UniProt | EBI | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(119) RefSeq(8) UniProt(2)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001112 Endothelin receptor B
InterPro IPR000499 Endothelin receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001222 endothelin B receptor
Graphical View of Protein Domain Structure
References (Earliest) J:23183 Dunn LC, Types of white spotting in mice. Am Naturalist. 1920 Nov-Dec;54:465-95
(Latest) J:201133 Rattner A, et al., Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-E3839
All references(187)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-14268, MGD-MRK-19624, MGI:2145744

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory