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Cav1
Gene Detail
 Symbol
Name
ID
Cav1
caveolin 1, caveolae protein
MGI:102709
Synonyms Cav-1, caveolin-1
Feature Type protein coding gene
Genetic Map
Chromosome 6
7.73 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:17306335-17341452 bp, + strand
From VEGA annotation of GRCm38

  35118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: caveolin-1
Gene Tree: Cav1

Human
homologs
Human Homolog CAV1, caveolin 1, caveolae protein, 22kDa
NCBI Gene ID 857
neXtProt AC  NX_Q03135
Human Synonyms  BSCL3, CGL3, MSTP085, PPH3, VIP21
Human Chr (Location)  7q31.1; chr7:116524785-116561185 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CAV1
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Homozygous targeted mutants displayed vascular system dysfunctions and thickening of lung aveloar septa from hyperproliferation and fibrosis, ultimately causing the mice physical limitations. Mice also display increased incidence of calcium calculi, kidney stones, and decreased adiposity.
 
Human Diseases Modeled Using Mouse Cav1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (153 annotations)
Process angiogenesis, apoptotic signaling pathway, ...
Component acrosomal membrane, apical plasma membrane, ...
Function enzyme binding, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (18)    Tissues (10)    Images (1)
Theiler Stages: 10, 15, 18, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 1
Northern blot 4
Western blot 9
RT-PCR 2
cDNA source data(145)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(149) Genomic(1) cDNA(146) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024023 (Evidence)
Ensembl Gene ModelENSMUSG00000007655 (Evidence)
Entrez Gene12389 (Evidence)
UniGene28278
DFCITC1574096, TC1640750
DoTSDT.94352429, DT.97356712
NIA Mouse Gene IndexU006564
Consensus CDS ProjectCCDS19924.1, CCDS57410.1
International Mouse Knockout Project StatusCav1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024023 VEGA Gene Model | MGI Sequence Detail 35118 C57BL/6J ±  kb
transcript OTTMUST00000058732 VEGA | MGI Sequence Detail 2522 Not Applicable 
polypeptide OTTMUSP00000028492 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(10) UniProt(6)
Polymorphisms SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001612 Caveolin
InterPro IPR015504 Caveolin-1
InterPro IPR018361 Caveolin, conserved site
Protein Ontology PR:000003198 caveolin-1
References (Earliest) J:20873 Tang ZL, et al., The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene. 1994 Sep 30;147(2):299-300
(Latest) J:206305 Gu X, et al., Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration. Am J Pathol. 2014 Feb;184(2):541-55
All references(324)
Other
accession IDs
MGD-MRK-19613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory