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Cav1
Gene Detail
Symbol

Name
ID
Cav1
caveolin 1, caveolae protein
MGI:102709
Synonyms
Cav-1, caveolin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
7.73 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:17306335-17341452 bp, + strand
From VEGA annotation of GRCm38

  35118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CAV1
Protein SuperFamily: caveolin-1
Gene Tree: Cav1

Human
homologs
CAV1, caveolin 1, caveolae protein, 22kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 857
neXtProt AC: NX_Q03135

Human Synonyms: BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21

Human Chr (Location): 7q31.1; chr7:116524785-116561185 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CAV1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants displayed vascular system dysfunctions and thickening of lung aveloar septa from hyperproliferation and fibrosis, ultimately causing the mice physical limitations. Mice also display increased incidence of calcium calculi, kidney stones, and decreased adiposity.
 
Human Diseases Modeled in Mice Using Cav1 (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Cav1 interacts with 315 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (198 annotations)
Process angiogenesis, angiotensin-activated signaling pathway involved in heart process, ...
Component acrosomal membrane, apical plasma membrane, ...
Function ATPase binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (14)    Tissues (10)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 1
Northern blot 4
Western blot 3
RT-PCR 2
cDNA source data(145)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cav1 ; ZFIN cav1    NEW 
Molecular
reagents
All nucleic(149) Genomic(1) cDNA(146) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024023 (Evidence)
Ensembl Gene Model ENSMUSG00000007655 (Evidence)
Entrez Gene 12389 (Evidence)
UniGene 28278
DFCI TC1640750, TC1574096
DoTS DT.97356712, DT.94352429
NIA Mouse Gene Index U006564
Consensus CDS Project CCDS19924.1, CCDS57410.1
International Mouse Phenotyping Consortium Status Cav1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024023 VEGA Gene Model | MGI Sequence Detail 35118 C57BL/6J ±  kb
transcript OTTMUST00000058732 VEGA | MGI Sequence Detail 2522 Not Applicable 
polypeptide OTTMUSP00000028492 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(10) UniProt(6)
Polymorphisms
SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001612 Caveolin
InterPro IPR015504 Caveolin-1
InterPro IPR018361 Caveolin, conserved site
Protein Ontology PR:000003198 caveolin-1
References
(Earliest) J:20873 Tang ZL, et al., The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene. 1994 Sep 30;147(2):299-300
(Latest) J:218740 Volonte D, et al., Oxidative Stress-induced Inhibition of Sirt1 by Caveolin-1 Promotes p53-dependent Premature Senescence and Stimulates the Secretion of Interleukin 6 (IL-6). J Biol Chem. 2015 Feb 13;290(7):4202-14
All references(354)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-19613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory