About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Cav1
Gene Detail
Symbol

Name
ID
Cav1
caveolin 1, caveolae protein
MGI:102709
Synonyms
Cav-1, caveolin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
7.73 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:17306335-17341452 bp, + strand
From VEGA annotation of GRCm38

  35118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: caveolin-1
Gene Tree: Cav1

Human
homologs
Human Homolog   CAV1, caveolin 1, caveolae protein, 22kDa
NCBI Gene ID 857
neXtProt AC  NX_Q03135
Human Synonyms  BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
Human Chr (Location)  7q31.1; chr7:116524785-116561185 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human CAV1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants displayed vascular system dysfunctions and thickening of lung aveloar septa from hyperproliferation and fibrosis, ultimately causing the mice physical limitations. Mice also display increased incidence of calcium calculi, kidney stones, and decreased adiposity.
 
Human Diseases Modeled in Mice Using Cav1 (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Cav1 interacts with 315 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (186 annotations)
Process angiogenesis, angiotensin-activated signaling pathway involved in heart process, ...
Component acrosomal membrane, apical plasma membrane, ...
Function enzyme binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (12)    Tissues (9)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 1
Northern blot 4
Western blot 3
RT-PCR 2
cDNA source data(145)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(149) Genomic(1) cDNA(146) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024023 (Evidence)
Ensembl Gene ModelENSMUSG00000007655 (Evidence)
Entrez Gene12389 (Evidence)
UniGene28278
DFCITC1640750, TC1574096
DoTSDT.97356712, DT.94352429
NIA Mouse Gene IndexU006564
Consensus CDS ProjectCCDS19924.1, CCDS57410.1
International Mouse Knockout Project StatusCav1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024023 VEGA Gene Model | MGI Sequence Detail 35118 C57BL/6J ±  kb
transcript OTTMUST00000058732 VEGA | MGI Sequence Detail 2522 Not Applicable 
polypeptide OTTMUSP00000028492 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(10) UniProt(11)
Polymorphisms
SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001612 Caveolin
InterPro IPR015504 Caveolin-1
InterPro IPR018361 Caveolin, conserved site
Protein Ontology PR:000003198 caveolin-1
References
(Earliest) J:20873 Tang ZL, et al., The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene. 1994 Sep 30;147(2):299-300
(Latest) J:216389 Li XC, et al., Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney. Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F949-61
All references(349)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-19613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory