Cav1
Gene Detail

Symbol Name ID

Cav1 caveolin 1, caveolae protein MGI:102709

Synonyms

Cav-1, caveolin-1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

7.73 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:17306335-17341452 bp, + strand From VEGA annotation of GRCm38   35118 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cav1 ± 2 cM)

Protein SuperFamily: caveolin-1
Gene Tree: Cav1

Human ortholog

CAV1 caveolin 1, caveolae protein, 22kDa NCBI Gene ID 857
Human Synonyms: BSCL3, CGL3, MSTP085, VIP21
Human Chr7:116164839-116201239 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CAV1 (1)

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygous targeted mutants displayed vascular system dysfunctions and thickening of lung aveloar septa from hyperproliferation and fibrosis, ultimately causing the mice physical limitations. Mice also display increased incidence of calcium calculi, kidney stones, and decreased adiposity.

 
Human Diseases Modeled Using Mouse Cav1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (146 annotations)

Process	angiogenesis, apoptotic signaling pathway, ...
Component	acrosomal membrane, apical plasma membrane, ...
Function	enzyme binding, kinase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (18)    Tissues (10)    Images (1)
Theiler Stages: 10, 15, 18, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	1
Northern blot	4
Western blot	9
RT-PCR	2

cDNA source data(146)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(150) Genomic(1) cDNA(147) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024023 (Evidence)
Ensembl Gene Model	ENSMUSG00000007655 (Evidence)
Entrez Gene	12389 (Evidence)
UniGene	28278
DFCI	TC1574096, TC1640750
DoTS	DT.94352429, DT.97356712
NIA Mouse Gene Index	U006564
Consensus CDS Project	CCDS19924.1, CCDS57410.1
International Mouse Knockout Project Status	Cav1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024023	VEGA Gene Model | MGI Sequence Detail	35118	C57BL/6J
transcript	OTTMUST00000058732	VEGA | MGI Sequence Detail	2522	Not Applicable
polypeptide	OTTMUSP00000028492	VEGA | MGI Sequence Detail	178	Not Applicable

All sequences(74) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(211 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001612	Caveolin
InterPro	IPR015504	Caveolin-1
InterPro	IPR018361	Caveolin, conserved site
Protein Ontology	PR:000003198	caveolin-1

References

(Earliest) J:20873 Tang ZL, et al., The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene. 1994 Sep 30;147(2):299-300
(Latest) J:192574 Li Z, et al., Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells in Vitro. Am J Pathol. 2013 Feb;182(2):325-31
All references(299)

Other accession IDs

MGD-MRK-19613