Abcc1
Gene Detail

Symbol Name ID

Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 MGI:102676

Synonyms

Abcc1a, Abcc1b, Mdrap, MRP, Mrp1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

9.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:14361558-14475737 bp, + strand From VEGA annotation of GRCm38   114180 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Abcc1 ± 2 cM)

Gene Tree: Abcc1

Human ortholog

ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 NCBI Gene ID 4363
Human Synonyms: ABC29, ABCC, GS-X, MRP, MRP1
Human Chr16:16043434-16236931 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(18) : Targeted(5) Gene trapped(13)
 

Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide.

 
Human Diseases Modeled Using Mouse Abcc1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	ATP catabolic process, cell chemotaxis, ...
Component	basolateral plasma membrane, cytoplasm, ...
Function	ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (143)    Tissues (133)    Images (6)
Theiler Stages: 12, 15, 22, 23, 28

Assay Type	Results
RNA in situ	137
RT-PCR	6

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(102) Genomic(2) cDNA(98) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000027051 (Evidence)
Ensembl Gene Model	ENSMUSG00000023088 (Evidence)
Entrez Gene	17250 (Evidence)
UniGene	196634
DFCI	TC1576429, TC1615344, TC1719785
DoTS	DT.101276318, DT.102534210, DT.91422443, DT.97410997
NIA Mouse Gene Index	U016842
Consensus CDS Project	CCDS37264.1
International Mouse Knockout Project Status	Abcc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027051	VEGA Gene Model | MGI Sequence Detail	114180	C57BL/6J
transcript	OTTMUST00000066858	VEGA | MGI Sequence Detail	6792	Not Applicable
polypeptide	OTTMUSP00000033565	VEGA | MGI Sequence Detail	1528	Not Applicable

All sequences(77) RefSeq(2) UniProt(10)

Polymorphisms

SNPs(970 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR017871	ABC transporter, conserved site
InterPro	IPR017940	ABC transporter, integral membrane type 1
InterPro	IPR003439	ABC transporter-like
InterPro	IPR001140	ABC transporter, transmembrane domain
InterPro	IPR011527	ABC transporter, transmembrane domain, type 1
InterPro	IPR005292	Multi drug resistance-associated protein
Protein Ontology	PR:000003554	multidrug resistance-associated protein 1

References

(Earliest) J:24061 Doggett NA, et al., Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994. Cytogenet Cell Genet. 1995;68(3-4):165-84
(Latest) J:187191 Schumacher T, et al., ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice. PLoS One. 2012;7(4):e35613
All references(83)

Other accession IDs

MGD-MRK-19579, MGI:2137380