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Abcc1
Gene Detail
 Symbol
Name
ID
Abcc1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
MGI:102676
Synonyms Abcc1a, Abcc1b, Mdrap, MRP, Mrp1
Feature Type protein coding gene
Genetic Map
Chromosome 16
9.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:14361558-14475737 bp, + strand
From VEGA annotation of GRCm38

  114180 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Abcc1

Human
homologs
Human Homolog ABCC1, ATP-binding cassette, sub-family C (CFTR/MRP), member 1
NCBI Gene ID 4363
neXtProt AC  NX_P33527
Human Synonyms  ABC29, ABCC, GS-X, MRP, MRP1
Human Chr (Location)  16p13.1; chr16:15949577-16143074 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Abcc1 interacts with 331 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process ATP catabolic process, cell chemotaxis, ...
Component basolateral plasma membrane, cytoplasm, ...
Function ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (143)    Tissues (133)    Images (6)
Theiler Stages: 12, 15, 22, 23, 28
Assay TypeResults
RNA in situ 137
RT-PCR 6
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(101) Genomic(2) cDNA(97) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027051 (Evidence)
Ensembl Gene ModelENSMUSG00000023088 (Evidence)
Entrez Gene17250 (Evidence)
UniGene196634
DFCITC1576429, TC1615344, TC1719785
DoTSDT.101276318, DT.102534210, DT.91422443, DT.97410997
NIA Mouse Gene IndexU016842
Consensus CDS ProjectCCDS37264.1
International Mouse Knockout Project StatusAbcc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027051 VEGA Gene Model | MGI Sequence Detail 114180 C57BL/6J ±  kb
transcript OTTMUST00000066858 VEGA | MGI Sequence Detail 6792 Not Applicable 
polypeptide OTTMUSP00000033565 VEGA | MGI Sequence Detail 1528 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(10) UniProt(10)
Polymorphisms SNPs within 2kb(1021 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR005292 Multi drug resistance-associated protein
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003554 multidrug resistance-associated protein 1
References (Earliest) J:24061 Doggett NA, et al., Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994. Cytogenet Cell Genet. 1995;68(3-4):165-84
(Latest) J:187191 Schumacher T, et al., ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice. PLoS One. 2012;7(4):e35613
All references(83)
Other
accession IDs
MGD-MRK-19579, MGI:2137380

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory