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Abcc1 Gene Detail
Summary
  • Symbol
    Abcc1
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 1
  • Synonyms
    Abcc1a, Abcc1b, Mdrap, MRP, Mrp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102676
    NCBI Gene: 17250
  • Gene Overview
    MyGene.info: ABCC1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:14361512-14474879 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 9.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    950 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102676
protein coding gene Chr16:14361512-14475737 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022545
protein coding gene Chr16:11408837-11533626 (+)
A/J MGP_AJ_G0022507
protein coding gene Chr16:10768469-10885622 (+)
AKR/J MGP_AKRJ_G0022483
protein coding gene Chr16:11248966-11369648 (+)
BALB/cJ MGP_BALBcJ_G0022511
protein coding gene Chr16:10942091-11065013 (+)
C3H/HeJ MGP_C3HHeJ_G0022278
protein coding gene Chr16:11340124-11462583 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022960
protein coding gene Chr16:11570113-11694687 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020480
protein coding gene Chr16:10889473-10991437 (+)
CAST/EiJ MGP_CASTEiJ_G0021805
protein coding gene Chr16:11380560-11500570 (+)
CBA/J MGP_CBAJ_G0022247
protein coding gene Chr16:12115028-12242596 (+)
DBA/2J MGP_DBA2J_G0022378
protein coding gene Chr16:10772736-10889682 (+)
FVB/NJ MGP_FVBNJ_G0022354
protein coding gene Chr16:10756005-10870575 (+)
LP/J MGP_LPJ_G0022446
protein coding gene Chr16:11301177-11425916 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022376
protein coding gene Chr16:11743288-11861995 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022973
protein coding gene Chr16:11210958-11336594 (+)
PWK/PhJ MGP_PWKPhJ_G0021547
protein coding gene Chr16:11027929-11142946 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021376
protein coding gene Chr16:11186409-11311709 (+)
WSB/EiJ MGP_WSBEiJ_G0021853
protein coding gene Chr16:11232221-11355337 (+)



Homology
more
  • Human Ortholog
    ABCC1, ATP binding cassette subfamily C member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ABCC1, ATP binding cassette subfamily C member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABC29, ABCC, GS-X, MRP, MRP1
  • Links
    NCBI Gene ID: 4363
    neXtProt AC: NX_P33527
    UniProt: P33527

  • Chr Location
    16p13.11; chr16:15949577-16143074 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17250 NCBI Gene Model | MGI Sequence Detail 113368 C57BL/6J ±  kb
    transcript NM_008576 RefSeq | MGI Sequence Detail 5959 C57BL/6  
    polypeptide O35379 UniProt | EBI | MGI Sequence Detail 1528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000003554 multidrug resistance-associated protein 1
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR017871 ABC transporter, conserved site
      IPR003439 ABC transporter-like
      IPR011527 ABC transporter type 1, transmembrane domain
      IPR036640 ABC transporter type 1, transmembrane domain superfamily
      IPR005292 Multi drug resistance-associated protein
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 2
      cDNA 98
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-19579, MGI:2137380
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 7
      Phenotypes 35
    • Earliest
      J:24061 Doggett NA, et al., Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994. Cytogenet Cell Genet. 1995;68(3-4):165-84
    • Latest
      J:241432 Bockor L, et al., Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia. Hum Mol Genet. 2017 Jan 01;26(1):145-157

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory