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Abcc1 Gene Detail
Summary
  • Symbol
    Abcc1
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 1
  • Synonyms
    Abcc1a, Abcc1b, Mdrap, MRP, Mrp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102676
    NCBI Gene: 17250
  • Gene Overview
    MyGene.info: ABCC1
Location & Maps
more
  • Sequence Map
    Chr16:14361558-14475737 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      114180 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 9.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ABCC1, ATP binding cassette subfamily C member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ABCC1, ATP binding cassette subfamily C member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABC29, ABCC, GS-X, MRP, MRP1
  • Links
    NCBI Gene ID: 4363
    neXtProt AC: NX_P33527

  • Chr Location
    16p13.1; chr16:15949577-16143074 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027051 VEGA Gene Model | MGI Sequence Detail 114180 C57BL/6J ±  kb
transcript OTTMUST00000066858 VEGA | MGI Sequence Detail 6792 Not Applicable  
polypeptide OTTMUSP00000033565 VEGA | MGI Sequence Detail 1528 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    958 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR017871 ABC transporter, conserved site
    IPR003439 ABC transporter-like
    IPR011527 ABC transporter type 1, transmembrane domain
    IPR005292 Multi drug resistance-associated protein
    IPR030241 Multidrug resistance-associated protein 1
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 101
    Genomic 2
    cDNA 97
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-19579, MGI:2137380
References
more
  • Summaries
    All 80
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 5
    Phenotypes 33
  • Earliest
    J:24061 Doggett NA, et al., Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994. Cytogenet Cell Genet. 1995;68(3-4):165-84
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory