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Lhx3
Gene Detail
 Symbol
Name
ID
Lhx3
LIM homeobox protein 3
MGI:102673
Synonyms Lim3, mLim-3, P-LIM
Feature Type protein coding gene
Genetic Map
Chromosome 2
18.44 cM, cytoband A2-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:26200212-26208289 bp, - strand
From VEGA annotation of GRCm38

  8078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lhx3

Human
homologs
Human Homolog LHX3, LIM homeobox 3
NCBI Gene ID 8022
neXtProt AC  NX_Q9UBR4
Human Synonyms  CPHD3, LIM3, M2-LHX3
Human Chr (Location)  9q34.3; chr9:136196250-136205109 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LHX3
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit failure of growth and differentiation of Rathke's pouch, lack both anterior and intermediate lobes of the pituitary gland, and die perinatally, within 24 hours of birth.
 
Human Diseases Modeled Using Mouse Lhx3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Lhx3 interacts with 112 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell differentiation, dorsal/ventral pattern formation, ...
Component intracellular, nucleus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (129 records)
Data Summary: Results (359)    Tissues (211)    Images (87)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 33
RNA in situ 300
Northern blot 24
RT-PCR 2
cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(3) cDNA(24) Primer pair(2) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012728 (Evidence)
Ensembl Gene ModelENSMUSG00000026934 (Evidence)
Entrez Gene16871 (Evidence)
UniGene386765
DFCITC1583743, TC1594343, TC1596887
NIA Mouse Gene IndexU022415
PDB2JTN, 2RGT
Consensus CDS ProjectCCDS38081.1, CCDS71004.1
International Mouse Knockout Project StatusLhx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012728 VEGA Gene Model | MGI Sequence Detail 8078 C57BL/6J ±  kb
transcript OTTMUST00000030389 VEGA | MGI Sequence Detail 2223 Not Applicable 
polypeptide OTTMUSP00000013661 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009793 LIM/homeobox protein Lhx3
References (Earliest) J:22277 Seidah NG, et al., The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary. DNA Cell Biol. 1994 Dec;13(12):1163-80
(Latest) J:207154 Balasubramanian R, et al., Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina. Gene Expr Patterns. 2014 Jan;14(1):1-8
All references(183)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory