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Lhx3
Gene Detail
Symbol

Name
ID
Lhx3
LIM homeobox protein 3
MGI:102673
Synonyms
Lim3, mLim-3, P-LIM
Feature Type
protein coding gene
Genetic Map
Chromosome 2
18.44 cM, cytoband A2-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:26200212-26208289 bp, - strand
From VEGA annotation of GRCm38

  8078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: LHX3
Gene Tree: Lhx3

Human
homologs
LHX3, LIM homeobox 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8022
neXtProt AC: NX_Q9UBR4

Human Synonyms: CPHD3, LIM3, M2-LHX3

Human Chr (Location): 9q34.3; chr9:136196250-136205109 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LHX3

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit failure of growth and differentiation of Rathke's pouch, lack both anterior and intermediate lobes of the pituitary gland, and die perinatally, within 24 hours of birth.
 
Human Diseases Modeled in Mice Using Lhx3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Lhx3 interacts with 111 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell differentiation, dorsal/ventral pattern formation, ...
Component intracellular, nucleus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (137 records)
Data Summary: Results (376)    Tissues (226)    Images (105)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 49
RNA in situ 301
Northern blot 24
RT-PCR 2
cDNA source data(22)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LHX3 ; Xenbase lhx3 ; ZFIN lhx3    NEW 
Molecular
reagents
All nucleic(36) Genomic(3) cDNA(24) Primer pair(2) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000012728 (Evidence)
Ensembl Gene Model ENSMUSG00000026934 (Evidence)
Entrez Gene 16871 (Evidence)
UniGene 386765
DFCI TC1596887, TC1594343, TC1583743
NIA Mouse Gene Index U022415
PDB 2RGT, 2JTN
Consensus CDS Project CCDS38081.1, CCDS71004.1
International Mouse Phenotyping Consortium Status Lhx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012728 VEGA Gene Model | MGI Sequence Detail 8078 C57BL/6J ±  kb
transcript OTTMUST00000030389 VEGA | MGI Sequence Detail 2223 Not Applicable 
polypeptide OTTMUSP00000013661 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009793 LIM/homeobox protein Lhx3
References
(Earliest) J:22277 Seidah NG, et al., The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary. DNA Cell Biol. 1994 Dec;13(12):1163-80
(Latest) J:217063 Zou M, et al., Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord. Dev Dyn. 2015 Jan;244(1):86-97
All references(188)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory