Runx3
Gene Detail

Symbol Name ID

Runx3 runt related transcription factor 3 MGI:102672

Synonyms

AML2, Cbfa3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

67.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:135120652-135177990 bp, + strand From VEGA annotation of GRCm38   57339 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37914  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: runt-related transcription factor RUNX
Gene Tree: Runx3

Human homologs

Human Homolog		RUNX3, runt-related transcription factor 3
NCBI Gene ID		864
neXtProt AC		NX_Q13761
Human Synonyms		AML2, CBFA3, PEBP2aC
Human Chr (Location)		1p36; chr1:25226002-25291501 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygous null mice have hyperplasia of the gastric mucosa that causes death by 10 days of age.

 
Human Diseases Modeled Using Mouse Runx3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	axon guidance, cell maturation, ...
Component	cytoplasm, nuclear chromatin, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (46 records)
Data Summary: Results (401)    Tissues (237)    Images (59)
Theiler Stages: 2, 3, 4, 5, 17, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	19
RNA in situ	346
RT-PCR	19
Nuclease S1	17

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(1) cDNA(30) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031877 (Evidence)
Ensembl Gene Model	ENSMUSG00000070691 (Evidence)
Entrez Gene	12399 (Evidence)
UniGene	378894
DFCI	TC1585984, TC1586187, TC1643689
DoTS	DT.101316870, DT.482800, DT.488511
NIA Mouse Gene Index	U336212
Consensus CDS Project	CCDS18782.1
International Mouse Knockout Project Status	Runx3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031877	VEGA Gene Model | MGI Sequence Detail	57339	C57BL/6J
transcript	OTTMUST00000079034	VEGA | MGI Sequence Detail	3884	Not Applicable
polypeptide	OTTMUSP00000042120	VEGA | MGI Sequence Detail	423	Not Applicable

All sequences(48) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(388 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000040	Acute myeloid leukemia 1 protein (AML1)/Runt
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain
InterPro	IPR013524	Runt domain
InterPro	IPR016554	Runt-related transcription factor RUNX
InterPro	IPR013711	Runx, C-terminal domain
Protein Ontology	PR:000014365	runt-related transcription factor 3

References

(Earliest) J:20817 Levanon D, et al., AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics. 1994 Sep 15;23(2):425-32
(Latest) J:195075 Xiong Y, et al., Thpok-independent repression of Runx3 by Gata3 during CD4(+) T-cell differentiation in the thymus. Eur J Immunol. 2013 Apr;43(4):918-28
All references(119)

Other accession IDs

MGD-MRK-19575