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Runx3
Gene Detail
Symbol

Name
ID
Runx3
runt related transcription factor 3
MGI:102672
Synonyms
AML2, Cbfa3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
67.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:135120652-135177990 bp, + strand
From VEGA annotation of GRCm38

  57339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37914  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: runt-related transcription factor RUNX
Gene Tree: Runx3

Human
homologs
Human Homolog RUNX3, runt-related transcription factor 3
NCBI Gene ID 864
neXtProt AC  NX_Q13761
Human Synonyms  AML2, CBFA3, PEBP2aC
Human Chr (Location)  1p36; chr1:24899511-24965115 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
 
Homozygous null mice have hyperplasia of the gastric mucosa that causes death by 10 days of age.
 
Human Diseases Modeled Using Mouse Runx3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Runx3 interacts with 227 markers (Mir7-1, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process axon guidance, cell maturation, ...
Component cytoplasm, nuclear chromatin, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (418)    Tissues (252)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 370
RT-PCR 12
Nuclease S1 17
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(30) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031877 (Evidence)
Ensembl Gene ModelENSMUSG00000070691 (Evidence)
Entrez Gene12399 (Evidence)
UniGene378894
DFCITC1586187, TC1585984, TC1643689
DoTSDT.101316870, DT.488511, DT.482800
NIA Mouse Gene IndexU336212
Consensus CDS ProjectCCDS18782.1
International Mouse Knockout Project StatusRunx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031877 VEGA Gene Model | MGI Sequence Detail 57339 C57BL/6J ±  kb
transcript OTTMUST00000079034 VEGA | MGI Sequence Detail 3884 Not Applicable 
polypeptide OTTMUSP00000042120 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(7)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(530 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
InterPro IPR013524 Runt domain
InterPro IPR016554 Runt-related transcription factor RUNX
InterPro IPR027384 Runx, central domain
InterPro IPR013711 Runx, C-terminal domain
Protein Ontology PR:000014365 runt-related transcription factor 3
References
(Earliest) J:20817 Levanon D, et al., AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics. 1994 Sep 15;23(2):425-32
(Latest) J:212995 Kakoi H, et al., Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism. J Biol Chem. 2014 Mar 21;289(12):8135-50
All references(130)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory