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Runx3 Gene Detail
Summary
  • Symbol
    Runx3
  • Name
    runt related transcription factor 3
  • Synonyms
    AML2, Cbfa3
  • Feature Type
    protein coding gene
  • IDs
    MGI:102672
    NCBI Gene: 12399
  • Gene Overview
    MyGene.info: RUNX3
Location & Maps
more
  • Sequence Map
    Chr4:135120652-135177990 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57339 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RUNX3, runt related transcription factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RUNX3, runt related transcription factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AML2, CBFA3, PEBP2aC
  • Links
    NCBI Gene ID: 864
    neXtProt AC: NX_Q13761

  • Chr Location
    1p36; chr1:24899511-24965157 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Runx3 mouse models

Human Disease Mouse Models
       Asthma, Susceptibility to   OMIM: 600807 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    95 phenotypes from 7 alleles in 12 genetic backgrounds
    8 phenotypes from multigenic genotypes
    3 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Targeted
    13
  • Genomic Mutations
    3 involving Runx3
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031877 VEGA Gene Model | MGI Sequence Detail 57339 C57BL/6J ±  kb
transcript OTTMUST00000079034 VEGA | MGI Sequence Detail 3884 Not Applicable  
polypeptide OTTMUSP00000042120 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    530 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014365 runt-related transcription factor 3
  • InterPro Domains
    IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
    IPR008967 p53-like transcription factor, DNA-binding
    IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
    IPR013524 Runt domain
    IPR027384 Runx, central domain
    IPR013711 Runx, C-terminal domain
Molecular
Reagents
less
  • All nucleic 39
    Genomic 1
    cDNA 31
    Primer pair 5
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19575
References
more
  • Summaries
    All 136
    Developmental Gene Expression 57
    Diseases 1
    Gene Ontology 14
    Phenotypes 61
  • Earliest
    J:23158 Avraham KB, et al., Mapping of the mouse homolog of the human runt domain gene, AML2, to the distal region of mouse chromosome 4. Genomics. 1995 Jan 20;25(2):603-5
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory