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Runx3
Gene Detail
Symbol

Name
ID
Runx3
runt related transcription factor 3
MGI:102672
Synonyms
AML2, Cbfa3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
67.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:135120652-135177990 bp, + strand
From VEGA annotation of GRCm38

  57339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37914  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RUNX3
Protein SuperFamily: runt-related transcription factor RUNX
Gene Tree: Runx3

Human
homologs
RUNX3, runt-related transcription factor 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 864
neXtProt AC: NX_Q13761

Human Synonyms: AML2, CBFA3, PEBP2aC

Human Chr (Location): 1p36; chr1:24899511-24965157 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Genomic Mutations involving Runx3 (1)
Human Diseases Modeled in Mice Using Runx3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Runx3 interacts with 227 markers (Mir7-1, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process axon guidance, cell maturation, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (53 records)
Data Summary: Results (422)    Tissues (256)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 374
RT-PCR 12
Nuclease S1 17
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN runx3    NEW 
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(31) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031877 (Evidence)
Ensembl Gene Model ENSMUSG00000070691 (Evidence)
Entrez Gene 12399 (Evidence)
UniGene 378894
DFCI TC1585984, TC1586187, TC1643689
DoTS DT.101316870, DT.482800, DT.488511
NIA Mouse Gene Index U336212
Consensus CDS Project CCDS18782.1
International Mouse Phenotyping Consortium Status Runx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031877 VEGA Gene Model | MGI Sequence Detail 57339 C57BL/6J ±  kb
transcript OTTMUST00000079034 VEGA | MGI Sequence Detail 3884 Not Applicable 
polypeptide OTTMUSP00000042120 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(4)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(530 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
InterPro IPR013524 Runt domain
InterPro IPR027384 Runx, central domain
InterPro IPR013711 Runx, C-terminal domain
Protein Ontology PR:000014365 runt-related transcription factor 3
References
(Earliest) J:23158 Avraham KB, et al., Mapping of the mouse homolog of the human runt domain gene, AML2, to the distal region of mouse chromosome 4. Genomics. 1995 Jan 20;25(2):603-5
(Latest) J:222534 Kurklu B, et al., Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer. Oncogene. 2015 May 28;34(22):2856-66
All references(135)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory