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Pmp2 Gene Detail
Summary
  • Symbol
    Pmp2
  • Name
    peripheral myelin protein 2
  • Synonyms
    P2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102667
    NCBI Gene: 18857
  • Gene Overview
    MyGene.info: PMP2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:10179851-10183885 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 2.54 cM
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102667
protein coding gene Chr3:10179851-10183929 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027060
protein coding gene Chr3:7145580-7149657 (-)
A/J MGP_AJ_G0027024
protein coding gene Chr3:7304542-7308620 (-)
AKR/J MGP_AKRJ_G0026994
protein coding gene Chr3:7206023-7210100 (-)
BALB/cJ MGP_BALBcJ_G0027033
protein coding gene Chr3:7002204-7006282 (-)
C3H/HeJ MGP_C3HHeJ_G0026773
protein coding gene Chr3:7511698-7515776 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027477
protein coding gene Chr3:7782542-7786620 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024839
protein coding gene Chr3:6186041-6190128 (-)
CAST/EiJ MGP_CASTEiJ_G0026231
protein coding gene Chr3:7534651-7538711 (-)
CBA/J MGP_CBAJ_G0026751
protein coding gene Chr3:7790988-7795066 (-)
DBA/2J MGP_DBA2J_G0026887
protein coding gene Chr3:6868936-6873014 (-)
FVB/NJ MGP_FVBNJ_G0026854
protein coding gene Chr3:6797476-6801553 (-)
LP/J MGP_LPJ_G0026997
protein coding gene Chr3:7667738-7671815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026875
protein coding gene Chr3:8818158-8822236 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027537
protein coding gene Chr3:7067212-7071290 (-)
PWK/PhJ MGP_PWKPhJ_G0025966
protein coding gene Chr3:7097235-7101282 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025769
protein coding gene Chr3:7209184-7213215 (-)
WSB/EiJ MGP_WSBEiJ_G0026302
protein coding gene Chr3:7096951-7101038 (-)



Homology
more
  • Human Ortholog
    PMP2, peripheral myelin protein 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    PMP2, peripheral myelin protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FABP8, M-FABP, MP2, P2
  • Links
    NCBI Gene ID: 5375
    neXtProt AC: NX_P02689
    UniProt: P02689

  • Chr Location
    8q21.13; chr8:81440326-81447484 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a temporary reduction in motor nerve conduction velocity and transitory alterations in the lipid profile of peripheral myelin but no major defects in general PNS myelin structure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18857 NCBI Gene Model | MGI Sequence Detail 4035 C57BL/6J ±  kb
transcript NM_001030305 RefSeq | MGI Sequence Detail 1364 C57BL/6  
polypeptide P24526 UniProt | EBI | MGI Sequence Detail 132 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 6
    Genomic 2
    cDNA 4

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-19568
References
more
  • Summaries
    All 22
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:11254 Narayanan V, et al., Structure of the mouse myelin P2 protein gene. J Neurochem. 1991 Jul;57(1):75-80
  • Latest
    J:211344 Zenker J, et al., A role of peripheral myelin protein 2 in lipid homeostasis of myelinating schwann cells. Glia. 2014 Sep;62(9):1502-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory