Ppp5c
Gene Detail

Symbol Name ID

Ppp5c protein phosphatase 5, catalytic subunit MGI:102666

Synonyms

ANP receptor, PP5

Feature Type

protein coding gene

Genetic Map

Chromosome 7

9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:17004640-17027924 bp, - strand From VEGA annotation of GRCm38   23285 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ppp5c ± 2 cM)

Protein SuperFamily: protein phosphatase 5
Gene Tree: Ppp5c

Human ortholog

PPP5C protein phosphatase 5, catalytic subunit NCBI Gene ID 5536
Human Synonyms: PP5, PPP5, PPT
Human Chr19:46850294-46894105 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(24) : Targeted(5) Gene trapped(19)
 

Mice homozygous for a null allele exhibit a decrease in cell cycle check-point arrest following treatment with ionizing radition.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	dephosphorylation, positive regulation of I-kappaB kinase/NF-kappaB cascade, ...
Component	cytoplasm, cytosol, ...
Function	hydrolase activity, identical protein binding, ...

External Resources: FuncBase

Expression

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(5)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016479 (Evidence)
Ensembl Gene Model	ENSMUSG00000003099 (Evidence)
Entrez Gene	19060 (Evidence)
DFCI	TC1573554
DoTS	DT.101268549, DT.110993235, DT.110993253, DT.535209
NIA Mouse Gene Index	U028196
EC	3.1.3.16
Consensus CDS Project	CCDS20859.1
International Mouse Knockout Project Status	Ppp5c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016479	VEGA Gene Model | MGI Sequence Detail	23285	C57BL/6J
transcript	OTTMUST00000039755	VEGA | MGI Sequence Detail	2072	Not Applicable
polypeptide	OTTMUSP00000017740	VEGA | MGI Sequence Detail	499	Not Applicable

All sequences(65) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(163 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR013235	PPP domain
InterPro	IPR011236	Serine/threonine protein phosphatase 5
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
Protein Ontology	PR:000013157	serine/threonine-protein phosphatase 5

References

(Earliest) J:21536 Chinkers M, Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11075-9
(Latest) J:186454 Grankvist N, et al., Serine/threonine protein phosphatase 5 regulates glucose homeostasis in vivo and apoptosis signalling in mouse pancreatic islets and clonal MIN6 cells. Diabetologia. 2012 Jul;55(7):2005-15
All references(43)

Other accession IDs

MGD-MRK-19567, MGI:2142135