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Ppp5c Gene Detail
Summary
  • Symbol
    Ppp5c
  • Name
    protein phosphatase 5, catalytic subunit
  • Synonyms
    ANP receptor, PP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:102666
    NCBI Gene: 19060
  • Gene Overview
    MyGene.info: PPP5C
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:17004640-17027914 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102666
protein coding gene Chr7:17004640-17027924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031727
protein coding gene Chr7:14781267-14805773 (-)
A/J MGP_AJ_G0031699
protein coding gene Chr7:14485881-14509045 (-)
AKR/J MGP_AKRJ_G0031624
protein coding gene Chr7:14831138-14854299 (-)
BALB/cJ MGP_BALBcJ_G0031706
protein coding gene Chr7:14596611-14620551 (-)
C3H/HeJ MGP_C3HHeJ_G0031428
protein coding gene Chr7:15017992-15041566 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032172
protein coding gene Chr7:15507058-15530946 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029251
protein coding gene Chr7:16028881-16059411 (-)
CAST/EiJ MGP_CASTEiJ_G0030779
protein coding gene Chr7:11795941-11819367 (-)
CBA/J MGP_CBAJ_G0031387
protein coding gene Chr7:16032721-16059453 (-)
DBA/2J MGP_DBA2J_G0031543
protein coding gene Chr7:14383557-14406875 (-)
FVB/NJ MGP_FVBNJ_G0031499
protein coding gene Chr7:14282430-14305513 (-)
LP/J MGP_LPJ_G0031628
protein coding gene Chr7:15026580-15049708 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031534
protein coding gene Chr7:15951025-15975548 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032201
protein coding gene Chr7:14614061-14638521 (-)
PWK/PhJ MGP_PWKPhJ_G0030503
protein coding gene Chr7:11902346-11926080 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030330
protein coding gene Chr7:9543281-9566868 (-)
WSB/EiJ MGP_WSBEiJ_G0030876
protein coding gene Chr7:14679196-14702154 (-)



Homology
more
  • Human Ortholog
    PPP5C, protein phosphatase 5 catalytic subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP5C, protein phosphatase 5 catalytic subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP5, PPP5, PPT
  • Links
    NCBI Gene ID: 5536
    neXtProt AC: NX_P53041
    UniProt: P53041

  • Chr Location
    19q13.32; chr19:46346994-46390975 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 6 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a decrease in cell cycle check-point arrest following treatment with ionizing radition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19060 NCBI Gene Model | MGI Sequence Detail 23275 C57BL/6J ±  kb
transcript NM_011155 RefSeq | MGI Sequence Detail 2084 C57BL/6  
polypeptide Q60676 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-19567, MGI:2142135
References
more
  • Summaries
    All 51
    Gene Ontology 11
    Phenotypes 18
  • Earliest
    J:21536 Chinkers M, Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11075-9
  • Latest
    J:218791 Jacob W, et al., Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5. Biochem J. 2015 Feb 15;466(1):163-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory