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Tbx4
Gene Detail
 Symbol
Name
ID
Tbx4
T-box 4
MGI:102556
Feature Type protein coding gene
Genetic Map
Chromosome 11
51.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:85886422-85916095 bp, + strand
From VEGA annotation of GRCm38

  29674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tbx4

Human
homologs
Human Homolog TBX4, T-box 4
NCBI Gene ID 9496
neXtProt AC  NX_P57082
Human Synonyms  SPS
Human Chr (Location)  17q21-q22; chr17:61451773-61485110 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TBX4
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(1) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit stunted, apoptotic allantoises lacking vascular remodeling, fail to undergo chorioallantoic fusion, lack hindlimb buds, and die by embryonic day 10.5. Heterozygotes show mildly impaired allantois growth.
 
Interactions
Tbx4 interacts with 194 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process angiogenesis, embryonic limb morphogenesis, ...
Component nucleus
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (63 records)
Data Summary: Results (218)    Tissues (131)    Images (67)
Theiler Stages: 2, 3, 4, 5, 10, 11, 13, 14, 15, 17, 18, 19, 20, 21, 23, 27, 28
Assay TypeResults
RNA in situ 209
Northern blot 1
RT-PCR 8
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(3) cDNA(16) Primer pair(1) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001043 (Evidence)
Ensembl Gene ModelENSMUSG00000000094 (Evidence)
Entrez Gene21387 (Evidence)
UniGene275336
DFCITC1583558, TC1598493
DoTSDT.87034137, DT.94146753
NIA Mouse Gene IndexU013124
Consensus CDS ProjectCCDS25196.1, CCDS48874.1
International Mouse Knockout Project StatusTbx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001043 VEGA Gene Model | MGI Sequence Detail 29674 C57BL/6J ±  kb
transcript OTTMUST00000002082 VEGA | MGI Sequence Detail 3153 Not Applicable 
polypeptide OTTMUSP00000001006 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016152 T-box transcription factor TBX4
References (Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:209070 Glaser A, et al., Tbx4 interacts with the short stature homeobox gene Shox2 in limb development. Dev Dyn. 2014 May;243(5):629-39
All references(105)
Other
accession IDs
MGD-MRK-19405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory