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Tbx6
Gene Detail
 Symbol
Name
ID
Tbx6
T-box 6
MGI:102539
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:126781483-126785560 bp, + strand
From VEGA annotation of GRCm38

  4078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3389  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tbx6

Human
homologs
Human Homolog TBX6, T-box 6
NCBI Gene ID 6911
neXtProt AC  NX_O95947
Human Synonyms  SCDO5
Human Chr (Location)  16p11.2; chr16:30085793-30091937 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(7)
Genomic Mutations involving Tbx6 (2)
Incidental mutations (data from Mutagenetix , APF )
Human Diseases Modeled Using Mouse Tbx6 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Tbx6 interacts with 95 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell fate specification, mesoderm formation, ...
Component nucleus
Function DNA binding, RNA polymerase II activating transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (224)    Tissues (138)    Images (51)
Theiler Stages: 2, 3, 5, 6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23
Assay TypeResults
RNA in situ 185
Northern blot 1
RT-PCR 38
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(12) Primer pair(2) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037609 (Evidence)
Ensembl Gene ModelENSMUSG00000030699 (Evidence)
Entrez Gene21389 (Evidence)
UniGene727
DFCITC1587622
DoTSDT.527101
NIA Mouse Gene IndexU008780
Consensus CDS ProjectCCDS21843.1
International Mouse Knockout Project StatusTbx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037609 VEGA Gene Model | MGI Sequence Detail 4078 C57BL/6J ±  kb
transcript OTTMUST00000097001 VEGA | MGI Sequence Detail 1529 Not Applicable 
polypeptide OTTMUSP00000054296 VEGA | MGI Sequence Detail 437 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(9) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR002070 Transcription factor, Brachyury
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016154 T-box transcription factor TBX6
References (Earliest) J:8119 Theiler K, et al., Development of rib-vertebrae: a new mutation in the house mouse with accessory caudal duplications. Anat Embryol (Berl). 1985;173(1):111-6
(Latest) J:201674 Xie Y, et al., The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex. Neuron. 2013 Jul 24;79(2):254-65
All references(113)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14254, MGD-MRK-19388, MGI:98208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory