Tbx6
Gene Detail

Symbol Name ID

Tbx6 T-box 6 MGI:102539

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr7:126781483-126785560 bp, + strand From VEGA annotation of GRCm38   4078 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3389  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tbx6

Human homologs

Human Homolog		TBX6, T-box 6
NCBI Gene ID		6911
neXtProt AC		NX_O95947
Human Chr (Location)		16p11.2; chr16:30097114-30103205 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(5) Spontaneous(1) Chemically induced(1)
 

Embryonic Ppp4c-deficiency leads to early embryonic lethality.

 
Human Diseases Modeled Using Mouse Tbx6 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell fate specification, mesoderm formation, ...
Component	nucleus
Function	DNA binding, RNA polymerase II activating transcription factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (68 records)
Data Summary: Results (215)    Tissues (136)    Images (46)
Theiler Stages: 2, 3, 5, 6, 9, 10, 11, 12, 13, 15, 16, 17, 19, 20, 21, 22, 23

Assay Type	Results
RNA in situ	176
Northern blot	1
RT-PCR	38

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(12) Primer pair(2) Other(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037609 (Evidence)
Ensembl Gene Model	ENSMUSG00000030699 (Evidence)
Entrez Gene	21389 (Evidence)
UniGene	727
DFCI	TC1587622
DoTS	DT.527101
NIA Mouse Gene Index	U008780
Consensus CDS Project	CCDS21843.1
International Mouse Knockout Project Status	Tbx6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037609	VEGA Gene Model | MGI Sequence Detail	4078	C57BL/6J
transcript	OTTMUST00000097001	VEGA | MGI Sequence Detail	1529	Not Applicable
polypeptide	OTTMUSP00000054296	VEGA | MGI Sequence Detail	437	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR002070	Transcription factor, Brachyury
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
Protein Ontology	PR:000016154	T-box transcription factor TBX6

References

(Earliest) J:8119 Theiler K, et al., Development of rib-vertebrae: a new mutation in the house mouse with accessory caudal duplications. Anat Embryol (Berl). 1985;173(1):111-6
(Latest) J:190545 Boulet AM, et al., Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45
All references(109)

Other accession IDs

MGD-MRK-14254, MGD-MRK-19388, MGI:98208