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Tbx6
Gene Detail
Symbol

Name
ID
Tbx6
T-box 6
MGI:102539
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:126781483-126785560 bp, + strand
From VEGA annotation of GRCm38

  4078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3389  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TBX6
Gene Tree: Tbx6

Human
homologs
TBX6, T-box 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6911
neXtProt AC: NX_O95947

Human Synonyms: SCDO5

Human Chr (Location): 16p11.2; chr16:30085793-30091937 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(8)
Genomic Mutations involving Tbx6 (6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null embryos die during organogenesis exhibiting defects in paraxial mesoderm differentiation, ectopic neural tube development, kinked neural tubes, impaired somite development, hematomas, enlarged tail buds, and laterality defects associated with nodal cilium anomalies.
 
Human Diseases Modeled in Mice Using Tbx6 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(1)
Interactions
Tbx6 interacts with 94 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell fate specification, mesoderm formation, ...
Component nucleus
Function DNA binding, RNA polymerase II activating transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (80 records)
Data Summary: Results (224)    Tissues (138)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 185
Northern blot 1
RT-PCR 38
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase MGC79458 ; ZFIN tbx6, tbx6l    NEW 
Molecular
reagents
All nucleic(21) cDNA(12) Primer pair(2) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037609 (Evidence)
Ensembl Gene Model ENSMUSG00000030699 (Evidence)
Entrez Gene 21389 (Evidence)
UniGene 727
DFCI TC1587622
DoTS DT.527101
NIA Mouse Gene Index U008780
Consensus CDS Project CCDS21843.1
International Mouse Phenotyping Consortium Status Tbx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037609 VEGA Gene Model | MGI Sequence Detail 4078 C57BL/6J ±  kb
transcript OTTMUST00000097001 VEGA | MGI Sequence Detail 1529 Not Applicable 
polypeptide OTTMUSP00000054296 VEGA | MGI Sequence Detail 437 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR002070 Transcription factor, Brachyury
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016154 T-box transcription factor TBX6
References
(Earliest) J:8119 Theiler K, et al., Development of rib-vertebrae: a new mutation in the house mouse with accessory caudal duplications. Anat Embryol (Berl). 1985;173(1):111-6
(Latest) J:221162 Zhao W, et al., Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2. Dev Biol. 2015 Apr 1;400(1):105-17
All references(119)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14254, MGD-MRK-19388, MGI:98208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory