Tbx6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tbx6
T-box 6
MGI:102539

54 phenotypes from 8 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tbx6^dd1/Tbx6^dd1 involves: C3HeB/FeJ * C57BL/6J	abnormal neural tube morphology	J:98216
Tbx6^dd1/Tbx6^dd1 involves: C3HeB/FeJ * C57BL/6J	abnormal paraxial mesoderm morphology	J:98216
Tbx6^em1Fzh/Tbx6⁺ FVB/NJ-Tbx6^em1Fzh	normal skeleton phenotype	J:271649
Tbx6^em1Fzh/Tbx6^em1Fzh FVB/NJ-Tbx6^em1Fzh	prenatal lethality, complete penetrance	J:271649
Tbx6^em1Fzh/Tbx6^em2Fzh FVB/NJ-Tbx6^em1Fzh Tbx6^em2Fzh	abnormal vertebrae development	J:271649
	rib fusion	J:271649
	vertebral fusion	J:271649
Tbx6^em1Jinli/Tbx6^em1Jinli C57BL/6J-Tbx6^em1Jinli	normal growth/size/body region phenotype	J:381215
Tbx6^em1Jinli/Tbx6^em1Jinli C57BL/6J-Tbx6^em1Jinli	short tail	J:381215
Tbx6^em2Fzh/Tbx6^em2Fzh FVB/NJ-Tbx6^em2Fzh	normal skeleton phenotype	J:271649
Tbx6^em3Fzh/Tbx6^em3Fzh C57BL/6J-Tbx6^em3Fzh	abnormal vertebrae morphology	J:288810
Tbx6^em3Fzh/Tbx6^em3Fzh C57BL/6J-Tbx6^em3Fzh	vertebral fusion	J:288810
Tbx6^rv/Tbx6^rv involves: C57BL/J * C57BL/6J	abnormal cervical atlas morphology	J:8119
	abnormal cervical vertebrae morphology	J:8119
	abnormal digestive system development	J:8119
	abnormal intervertebral disk development	J:8119
	abnormal lumbar vertebrae morphology	J:8119
	abnormal neural tube morphology	J:8119
	abnormal notochord morphology	J:8119
	abnormal somite development	J:8119
	abnormal tail development	J:8119
	abnormal thoracic vertebrae morphology	J:8119
	abnormal vertebral arch development	J:8119
	abnormal vertebral articular process morphology	J:8119
	abnormal vertebral body development	J:8119
	abnormal vertebral column morphology	J:8119
	abnormal vertebral transverse process morphology	J:8119
	cervical vertebral fusion	J:8119
	decreased body length	J:8119
	enlarged vertebral body	J:8119
	fused somites	J:8119
	fusion of vertebral arches	J:8119
	fusion of vertebral bodies	J:8119
	kidney cyst	J:8119
	kinked tail	J:8119
	reduced female fertility	J:8119
	rib fusion	J:8119
	short tail	J:8119
	single kidney	J:8119
	small vertebral body	J:8119
Tbx6^rv/Tbx6^tm2Pa involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57L/J * ICR	normal cardiovascular system phenotype	J:137163
	normal embryo phenotype	J:137163
Tbx6^tm1Pa/Tbx6⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	increased brain size	J:343325
	increased hippocampal fimbria size	J:343325
	increased piriform cortex size	J:343325
	increased retrosplenial granular cortex size	J:343325
	increased secondary somatosensory cortex size	J:343325
	thickened cerebral cortex	J:343325
Tbx6^tm1Pa/Tbx6^tm1Pa involves: 129S1/Sv * 129X1/SvJ	abnormal mesoderm development	J:217059
Tbx6^tm1Pa/Tbx6^tm1Pa involves: 129S1/Sv * 129X1/SvJ	abnormal neural tube morphology	J:217059
Tbx6^tm1Pa/Tbx6^tm1Pa involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal intersomitic artery morphology	J:80954
	abnormal paraxial mesoderm morphology	J:80954
	abnormal vascular development	J:80954
	embryonic lethality during organogenesis, complete penetrance	J:80954
	enlarged tail bud	J:80954
	hematoma	J:80954
	impaired somite development	J:80954
	kinked neural tube	J:80954
Tbx6^tm1Pa/Tbx6^tm2Pa involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR	abnormal direction of embryo turning	J:137163
	abnormal direction of heart looping	J:137163
	abnormal motile primary cilium morphology	J:137163

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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