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mt-Nd2 Gene Detail
Summary
  • Symbol
    mt-Nd2
  • Name
    mitochondrially encoded NADH dehydrogenase 2
  • Synonyms
    URF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102500
    NCBI Gene: 17717
  • Gene Overview
    MyGene.info: ND2
Location & Maps
more
  • Genetic Map
    Chromosome MT, Syntenic
Homology
more
  • Human Ortholog
    ND2, MTND2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ND2, MTND2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MTND2
  • Links
    NCBI Gene ID: 4536
    neXtProt AC: NX_P03891

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    1 with human ND2 associations

Human Disease Mouse Models
       Leber Optic Atrophy   OMIM: 535000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    4
  • Spontaneous
    1
A single point mutation specific to the ALR/Lt strain confers increased resistance to autoimmune diabetes. A conplastic strain generated with ALR nuclear DNA and NOD mtDNA exhibits increased mitochondrial ROS production relative to either parental strain, NOD.mtALR or C57BL/6 controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064345 Ensembl Gene Model | MGI Sequence Detail 1038 C57BL/6J ±  kb
transcript ENSMUST00000082396 Ensembl | MGI Sequence Detail 1038 Not Applicable  
polypeptide ENSMUSP00000080992 Ensembl | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    28 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032164 NADH-ubiquinone oxidoreductase chain 2
  • EC
  • InterPro Domains
    IPR010933 NADH dehydrogenase subunit 2, C-terminal
    IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
    IPR003917 NADH:ubiquinone oxidoreductase, chain 2
Molecular
Reagents
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  • All nucleic 69
    cDNA 16
    Primer pair 1
    Other 52
Other
Accession IDs
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MGD-MRK-19337, MGI:2139164, MGI:2139169, MGI:2139170, MGI:2139183, MGI:2139189, MGI:2139190, MGI:2139191, MGI:2139224
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:224310 Ishihara T, et al., Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015 Jan;35(1):211-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory