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mt-Nd4 Gene Detail
Summary
  • Symbol
    mt-Nd4
  • Name
    mitochondrially encoded NADH dehydrogenase 4
  • Synonyms
    URF4
  • Feature Type
    protein coding gene
  • IDs
    MGI:102498
    NCBI Gene: 17719
  • Gene Overview
    MyGene.info: ND4
Location & Maps
more
  • Genetic Map
    Chromosome MT, Syntenic
Homology
more
  • Human Ortholog
    ND4, NADH dehydrogenase, subunit 4 (complex I)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ND4, NADH dehydrogenase, subunit 4 (complex I)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MTND4
  • Links
    NCBI Gene ID: 4538
    neXtProt AC: NX_P03905

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    1 with human ND4 associations

Human Disease Mouse Models
       Leber Optic Atrophy   OMIM: 535000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    1
  • Spontaneous
    1
  • Genomic Mutations
    1 involving mt-Nd4
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064363 Ensembl Gene Model | MGI Sequence Detail 1378 C57BL/6J ±  kb
transcript ENSMUST00000082414 Ensembl | MGI Sequence Detail 1378 Not Applicable  
polypeptide ENSMUSP00000081000 Ensembl | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    34 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030541 NADH-ubiquinone oxidoreductase chain 4
  • EC
  • InterPro Domains
    IPR010227 NADH-quinone oxidoreductase, chain M/4
    IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
    IPR003918 NADH:ubiquinone oxidoreductase
    IPR000260 NADH:ubiquinone oxidoreductase chain 4, N-terminal
Molecular
Reagents
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  • All nucleic 66
    cDNA 14
    Other 52
Other
Accession IDs
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MGD-MRK-19335, MGI:2138392, MGI:2138399, MGI:2138421, MGI:2138441
References
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  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:224897 Yu H, et al., Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice. Proc Natl Acad Sci U S A. 2015 Oct 5;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory