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mt-Nd6
Gene Detail
Symbol

Name
ID
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
MGI:102495
Synonyms
ENSMUSG00000064368, URF6
Feature Type
protein coding gene
Genetic Map
Chromosome MT
Syntenic
Sequence Map
ChrMT:13552-14070 bp, - strand
From Ensembl annotation of GRCm38

  519 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:5022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: mt-Nd6

Human
homologs
Human Homolog ND6, NADH dehydrogenase, subunit 6 (complex I)
NCBI Gene ID 4541
neXtProt AC  NX_P03923
Human Synonyms  MTND6
Human Chr (Location)  MT
Disease Associations  (1) Diseases Associated with Human ND6
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically and radiation induced(1) Spontaneous(3)
 
Mice homoplastic for mitochondria containing a point mutation allele exhibit decreased mitochondrial oxidation and elevated lactate serum levels. Mice with mitochondria containing an insertion exhibit decreased mitochondrial oxidation.
 
Human Diseases Modeled Using Mouse mt-Nd6 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process oxidation-reduction process, transport
Component integral component of membrane, membrane, ...
Function NADH dehydrogenase (ubiquinone) activity, oxidoreductase activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (7)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 5
cDNA source data(22)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(22) Primer pair(1) Other(52)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000064368 (Evidence)
Entrez Gene17722
EC1.6.5.3
International Mouse Knockout Project Statusmt-Nd6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064368 Ensembl Gene Model | MGI Sequence Detail 519 C57BL/6J ±  kb
transcript ENSMUST00000082419 Ensembl | MGI Sequence Detail 519 Not Applicable 
polypeptide ENSMUSP00000081002 Ensembl | MGI Sequence Detail 172 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(1) UniProt(7)
Polymorphisms
SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010934 NADH dehydrogenase subunit 5, C-terminal
InterPro IPR001750 NADH:ubiquinone/plastoquinone oxidoreductase
InterPro IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6
Protein Ontology PR:000010694 NADH-ubiquinone oxidoreductase chain 6
References
(Earliest) J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
(Latest) J:192260 Lin CS, et al., Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20065-70
All references(36)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19332, MGI:2140439, MGI:2140440, MGI:2140446, MGI:2140451, MGI:2140454, MGI:2140456, MGI:2140458, MGI:2153793, MGI:3809053

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory