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mt-Nd6
Gene Detail
Symbol

Name
ID
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
MGI:102495
Synonyms
ENSMUSG00000064368, URF6
Feature Type
protein coding gene
Genetic Map
Chromosome MT
Syntenic
Sequence Map
ChrMT:13552-14070 bp, - strand
From Ensembl annotation of GRCm38

  519 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:5022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: ND6
Gene Tree: mt-Nd6

Human
homologs
ND6, NADH dehydrogenase, subunit 6 (complex I)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4541
neXtProt AC: NX_P03923

Human Synonyms: MTND6

Human Chr (Location): MT

Disease Associations: (2) Diseases Associated with Human ND6

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically and radiation induced(1) Spontaneous(4)
Genomic Mutations involving mt-Nd6 (1)
 
Mice homoplastic for mitochondria containing a point mutation allele exhibit decreased mitochondrial oxidation and elevated lactate serum levels. Mice with mitochondria containing an insertion exhibit decreased mitochondrial oxidation.
 
Human Diseases Modeled in Mice Using mt-Nd6 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(7)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process oxidation-reduction process, transport
Component integral component of membrane, membrane, ...
Function NADH dehydrogenase (ubiquinone) activity, oxidoreductase activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (7)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 5
cDNA source data(22)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(22) Primer pair(1) Other(52)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000064368 (Evidence)
Entrez Gene 17722
EC 1.6.5.3
International Mouse Phenotyping Consortium Status mt-Nd6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064368 Ensembl Gene Model | MGI Sequence Detail 519 C57BL/6J ±  kb
transcript ENSMUST00000082419 Ensembl | MGI Sequence Detail 519 Not Applicable 
polypeptide ENSMUSP00000081002 Ensembl | MGI Sequence Detail 172 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(1) UniProt(4)
Polymorphisms
SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010934 NADH dehydrogenase subunit 5, C-terminal
InterPro IPR001750 NADH:ubiquinone/plastoquinone oxidoreductase
InterPro IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6
Protein Ontology PR:000010694 NADH-ubiquinone oxidoreductase chain 6
References
(Earliest) J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
(Latest) J:192260 Lin CS, et al., Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20065-70
All references(34)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19332, MGI:2140439, MGI:2140440, MGI:2140446, MGI:2140451, MGI:2140454, MGI:2140456, MGI:2140458, MGI:2153793, MGI:3809053

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory