mt-Nd6^m2Jiha
Spontaneous Allele Detail

Summary

• Symbol: mt-Nd6^m2Jiha
• Name: mitochondrially encoded NADH dehydrogenase 6; mutation 2, Jun-Ichi Hayashi
• MGI ID: MGI:4834201
• Synonyms: G13997A
• Gene: mt-Nd6 Location: ChrMT:13552-14070 bp, - strand Genetic Position: ChrMT, Syntenic
• Alliance: mt-Nd6^m2Jiha page

Mutation origin

• Strain of Origin: C3H/An

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: ES cells were pretreated with rhodamine 6G to removed endogenous mitochondria and mtDNA prior to fusion with B82mtA11 mitochondria donor cells (derived from the L929 fibroblast cell line; C3H/An mouse strain) containing a G-to-A transition at position 13,997 (g.13997G>A) resulting in the substitution of proline 25 with leucine (p.P25L). (J:164405, J:164565)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying mt-Nd6^m2Jiha

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any mt-Nd6 Mutation: 0 strains or lines available

References

• Original: J:164405 Yokota M, et al., Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells. FEBS Lett. 2010 Sep 24;584(18):3943-8
• All: 5 reference(s)