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Rad52 Gene Detail
Summary
  • Symbol
    Rad52
  • Name
    RAD52 homolog, DNA repair protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:101949
    NCBI Gene: 19365
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:119879659-119899789 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.86 cM, cytoband G3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101949
 protein coding gene Chr6:119878781-119899789 (+)
129S1/SvImJ ENSMUSG00200049090
 protein coding gene Chr6:117082218-117100754 (+)
A/J ENSMUSG00195036588
 protein coding gene Chr6:116494822-116515353 (+)
AKR/J ENSMUSG00220022133
 protein coding gene Chr6:115369507-115388014 (+)
BALB/cJ ENSMUSG00180037431
 protein coding gene Chr6:116862505-116883035 (+)
C3H/HeJ ENSMUSG00175037497
 protein coding gene Chr6:60587196-60607720 (-)
C57BL/6NJ ENSMUSG00215047654
 protein coding gene Chr6:116846061-116866617 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028796
 protein coding gene Chr6:114938345-114958389 (+)
CAST/EiJ ENSTCUG00005050452
 protein coding gene Chr6:116657765-116678127 (+)
CBA/J ENSMUSG00210042689
 protein coding gene Chr6:116629586-116650103 (+)
DBA/2J ENSMUSG00185045612
 protein coding gene Chr6:117280288-117298832 (+)
FVB/NJ ENSMUSG00205024006
 protein coding gene Chr6:115729447-115750002 (+)
JF1/MsJ ENSUMUG00000049923
 protein coding gene Chr6:115872968-115893388 (+)
LP/J ENSMUSG00230042467
 protein coding gene Chr6:118479646-118498183 (+)
NOD/ShiLtJ ENSMUSG00190042501
 protein coding gene Chr6:116242511-116263028 (+)
NZO/HlLtJ ENSMUSG00225045204
 protein coding gene Chr6:120370354-120390862 (+)
PWK/PhJ ENSLUMG00010037906
 protein coding gene Chr6:115227361-115247775 (+)
SPRET/EiJ ENSMSPG00010040805
 protein coding gene Chr6:118111665-118131618 (+)
WSB/EiJ ENSIUOG00005040751
 protein coding gene Chr6:116901689-116922195 (+)



Homology
more
  • Human Ortholog
    RAD52, RAD52 DNA repair protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD52, RAD52 DNA repair protein
  • Links
    NCBI Gene ID: 5893
    UniProt: P43351

  • Chr Location
    12p13.33; chr12:910870-991122 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human RAD52 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    17 phenotype references
Mice homozygous for a null allele exhibit normal reproductive and immune systems.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    40
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030166 Ensembl Gene Model | MGI Sequence Detail 20131 C57BL/6J ±  kb
transcript ENSMUST00000162461 Ensembl | MGI Sequence Detail 1693 Not Applicable  
polypeptide ENSMUSP00000125502 Ensembl | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 4
    cDNA 40

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-18783
References
more
  • Summaries
    All 60
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:20732 Bendixen C, et al., Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52. Genomics. 1994 Sep 1;23(1):300-3
  • Latest
    J:338642 Xu Y, et al., Rad52 mediates class-switch DNA recombination to IgD. Nat Commun. 2022 Feb 21;13(1):980
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory