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Rad52 Gene Detail
Summary
  • Symbol
    Rad52
  • Name
    RAD52 homolog, DNA repair protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:101949
    NCBI Gene: 19365
  • Gene Overview
    MyGene.info: RAD52
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:119902698-119922828 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 56.86 cM, cytoband G3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101949
protein coding gene Chr6:119902198-119922828 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031197
protein coding gene Chr6:122742071-122765416 (+)
A/J MGP_AJ_G0031166
protein coding gene Chr6:118037204-118058043 (+)
AKR/J MGP_AKRJ_G0031097
protein coding gene Chr6:121210102-121229266 (+)
BALB/cJ MGP_BALBcJ_G0031177
protein coding gene Chr6:117803954-117824505 (+)
C3H/HeJ MGP_C3HHeJ_G0030532
protein coding gene Chr6:63082188-63104275 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031635
protein coding gene Chr6:125877450-125898015 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028796
protein coding gene Chr6:114938345-114958389 (+)
CAST/EiJ MGP_CASTEiJ_G0030284
protein coding gene Chr6:121652513-121673003 (+)
CBA/J MGP_CBAJ_G0030860
protein coding gene Chr6:130871820-130897314 (+)
DBA/2J MGP_DBA2J_G0031016
protein coding gene Chr6:116934055-116952373 (+)
FVB/NJ MGP_FVBNJ_G0030968
protein coding gene Chr6:116050816-116071573 (+)
LP/J MGP_LPJ_G0031095
protein coding gene Chr6:122746825-122764680 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031002
protein coding gene Chr6:134852839-134880201 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031664
protein coding gene Chr6:121243110-121264535 (+)
PWK/PhJ MGP_PWKPhJ_G0029999
protein coding gene Chr6:115957480-115978093 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029828
protein coding gene Chr6:119973722-119993607 (+)
WSB/EiJ MGP_WSBEiJ_G0030367
protein coding gene Chr6:121523180-121545375 (+)



Homology
more
  • Human Ortholog
    RAD52, RAD52 homolog, DNA repair protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAD52, RAD52 homolog, DNA repair protein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5893
    neXtProt AC: NX_P43351
    UniProt: P43351

  • Chr Location
    12p13.33; chr12:911028-991195 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    10 phenotype references
Mice homozygous for a null allele exhibit normal reproductive and immune systems.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030166 Ensembl Gene Model | MGI Sequence Detail 20131 C57BL/6J ±  kb
transcript ENSMUST00000162461 Ensembl | MGI Sequence Detail 1693 Not Applicable  
polypeptide ENSMUSP00000125502 Ensembl | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 4
    cDNA 40

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-18783
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:20732 Bendixen C, et al., Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52. Genomics. 1994 Sep 1;23(1):300-3
  • Latest
    J:244154 Zan H, et al., Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination. Nat Commun. 2017 Feb 08;8:14244

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory