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Tfdp1
Gene Detail
Symbol

Name
ID
Tfdp1
transcription factor Dp 1
MGI:101934
Synonyms
Dp1, Drtf1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.78 cM, cytoband A1-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:13339674-13377702 bp, + strand
From Ensembl annotation of GRCm38

  38029 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TFDP1
Protein SuperFamily: transcription factor DP
Gene Tree: Tfdp1

Human
homologs
TFDP1, transcription factor Dp-1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7027
neXtProt AC: NX_Q14186

Human Synonyms: Dp-1, DP1, DRTF1

Human Chr (Location): 13q34; chr13:113584688-113641473 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(33) Targeted(1)
Incidental mutations (data from Mutagenetix , CvDC )
 
Homozygotes for a targeted null mutation exhibit reduced expansion of the ectoplacental cone and chorion, small yolk sacs, and impaired endoreduplication in trophoblast giant cells. Mutants die by embryonic day 12.5.
 
Interactions
Tfdp1 interacts with 67 markers (Mir15a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process anoikis, cell cycle, ...
Component nucleoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (167)    Tissues (119)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 120
Western blot 32
RT-PCR 8
cDNA source data(105)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tfdp1 ; ZFIN tfdp1a, tfdp1b    NEW 
Molecular
reagents
All nucleic(115) Genomic(4) cDNA(108) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000038482 (Evidence)
Entrez Gene 21781 (Evidence)
UniGene 925
DFCI TC1605725, TC1621783, TC1574248
DoTS DT.94156122, DT.94156134, DT.99860040, DT.110631907, DT.101239430, DT.101737934
NIA Mouse Gene Index U009104, U136210
Consensus CDS Project CCDS22110.1
International Mouse Phenotyping Consortium Status Tfdp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038482 Ensembl Gene Model | MGI Sequence Detail 38029 C57BL/6J ±  kb
transcript ENSMUST00000170909 Ensembl | MGI Sequence Detail 1700 Not Applicable 
polypeptide ENSMUSP00000127952 Ensembl | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(20) UniProt(4)
Polymorphisms
SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015648 Transcription factor DP
InterPro IPR014889 Transcription factor DP, C-terminal
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000016269 transcription factor Dp-1
References
(Earliest) J:17080 Girling R, et al., A new component of the transcription factor DRTF1/E2F [published erratum appears in Nature 1993 Sep 30;365(6445):468]. Nature. 1993 Mar 4;362(6415):83-7
(Latest) J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8
All references(60)
Other
accession IDs
MGD-MRK-18766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory