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Tfdp1
Gene Detail
 Symbol
Name
ID
Tfdp1
transcription factor Dp 1
MGI:101934
Synonyms Dp1, Drtf1
Feature Type protein coding gene
Genetic Map
Chromosome 8
5.78 cM, cytoband A1-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:13339674-13377702 bp, + strand
From NCBI annotation of GRCm38

  38029 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor DP
Gene Tree: Tfdp1

Human
homologs
Human Homolog TFDP1, transcription factor Dp-1
NCBI Gene ID 7027
neXtProt AC  NX_Q14186
Human Synonyms  Dp-1, DP1, DRTF1
Human Chr (Location)  13q34; chr13:113584688-113641473 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(33) Targeted(1)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for a targeted null mutation exhibit reduced expansion of the ectoplacental cone and chorion, small yolk sacs, and impaired endoreduplication in trophoblast giant cells. Mutants die by embryonic day 12.5.
 
Interactions
Tfdp1 interacts with 67 markers (Mir15a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process anoikis, cell cycle, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (167)    Tissues (117)    Images (30)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 18, 19, 20, 21, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 120
Western blot 32
RT-PCR 8
cDNA source data(105)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(115) Genomic(4) cDNA(108) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000038482 (Evidence)
Entrez Gene21781 (Evidence)
UniGene925
DFCITC1574248, TC1605725, TC1621783
DoTSDT.101239430, DT.101737934, DT.110631907, DT.94156122, DT.94156134, DT.99860040
NIA Mouse Gene IndexU009104, U136210
Consensus CDS ProjectCCDS22110.1
International Mouse Knockout Project StatusTfdp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21781 NCBI Gene Model | MGI Sequence Detail 38029 C57BL/6J ±  kb
transcript NM_009361 RefSeq | MGI Sequence Detail 2584 C57BL/6 
polypeptide Q08639 UniProt | EBI | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(18) UniProt(4)
Polymorphisms SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015648 Transcription factor DP
InterPro IPR014889 Transcription factor DP, C-terminal
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000016269 transcription factor Dp-1
Graphical View of Protein Domain Structure
References (Earliest) J:17080 Girling R, et al., A new component of the transcription factor DRTF1/E2F [published erratum appears in Nature 1993 Sep 30;365(6445):468]. Nature. 1993 Mar 4;362(6415):83-7
(Latest) J:197738 Muller GA, et al., The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes. Nucleic Acids Res. 2012 Feb;40(4):1561-78
All references(59)
Other
accession IDs
MGD-MRK-18766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory