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Tfdp1 Gene Detail
Summary
  • Symbol
    Tfdp1
  • Name
    transcription factor Dp 1
  • Synonyms
    Dp1, Drtf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101934
    NCBI Gene: 21781
  • Gene Overview
    MyGene.info: TFDP1
Location & Maps
more
  • Sequence Map
    Chr8:13338751-13378448 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39698 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.78 cM, cytoband A1-A3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TFDP1, transcription factor Dp-1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TFDP1, transcription factor Dp-1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DILC, Dp-1, DP1, DRTF1
  • Links
    NCBI Gene ID: 7027
    neXtProt AC: NX_Q14186

  • Chr Location
    13q34; chr13:113584688-113641473 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced expansion of the ectoplacental cone and chorion, small yolk sacs, and impaired endoreduplication in trophoblast giant cells. Mutants die by embryonic day 12.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060903 VEGA Gene Model | MGI Sequence Detail 39698 C57BL/6J ±  kb
transcript OTTMUST00000148852 VEGA | MGI Sequence Detail 2511 Not Applicable  
polypeptide OTTMUSP00000077325 VEGA | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    326 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 115
    Genomic 4
    cDNA 108
    Primer pair 1
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-18766
References
more
  • Summaries
    All 59
    Developmental Gene Expression 18
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:17080 Girling R, et al., A new component of the transcription factor DRTF1/E2F [published erratum appears in Nature 1993 Sep 30;365(6445):468]. Nature. 1993 Mar 4;362(6415):83-7
  • Latest
    J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory