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Cpe Gene Detail
Summary
  • Symbol
    Cpe
  • Name
    carboxypeptidase E
  • Synonyms
    carboxypeptidase H, CPH, Cph1, Cph-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101932
    NCBI Gene: 12876
Location & Maps
more
  • Sequence Map
    Chr8:64592558-64693040 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100483 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CPE, carboxypeptidase E
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPE, carboxypeptidase E
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPH
  • Links
    NCBI Gene ID: 1363
    neXtProt AC: NX_P16870

  • Chr Location
    4q32.3; chr4:165378945-165498330 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cpe mouse models

Human Disease Mouse Models
       Obesity   OMIM: 601665 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Cpe
  • Incidental Mutations
Mice homozygous for a spontaneous or a targeted null mutation display progressive obesity, abnormal blood glucose and lipid regulation, and have reduced fertility. Aberrant prohormone processing and secretion appears to be the cause of these phenotypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037852 Ensembl Gene Model | MGI Sequence Detail 100483 C57BL/6J ±  kb
transcript ENSMUST00000048967 Ensembl | MGI Sequence Detail 2087 Not Applicable  
polypeptide ENSMUSP00000048555 Ensembl | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    970 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 1
    cDNA 11
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-18763, MGD-MRK-2106, MGD-MRK-2107, MGD-MRK-9713, MGI:2142890
References
more
  • Summaries
    All 118
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 6
    Phenotypes 59
  • Earliest
    J:13651 Hummel KP, et al., fat = fat, Chr UN. Mouse News Lett. 1974;50:43
  • Latest
    J:225276 Qin XY, et al., carboxypeptidase E-DeltaN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity. PLoS One. 2014;9(11):e112996

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory