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Cpe
Gene Detail
 Symbol
Name
ID
Cpe
carboxypeptidase E
MGI:101932
Synonyms carboxypeptidase H, CPH, Cph1, Cph-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
32.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr8:64592558-64693040 bp, - strand
From Ensembl annotation of GRCm38

  100483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: carboxypeptidase, M type
Gene Tree: Cpe

Human
homologs
Human Homolog CPE, carboxypeptidase E
NCBI Gene ID 1363
neXtProt AC  NX_P16870
Human Chr (Location)  4q32.3; chr4:165378945-165498330 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous or a targeted null mutation display progressive obesity, abnormal blood glucose and lipid regulation, and have reduced fertility. Aberrant prohormone processing and secretion appears to be the cause of these phenotypes.
 
Human Diseases Modeled Using Mouse Cpe (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cpe interacts with 93 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cardiac left ventricle morphogenesis, enkephalin processing, ...
Component cytoplasmic vesicle, dendrite, ...
Function carboxypeptidase activity, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (162)    Tissues (140)    Images (44)
Theiler Stages: 1, 2, 3, 5, 19, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 153
Western blot 4
RT-PCR 5
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(11) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000037852 (Evidence)
Entrez Gene12876 (Evidence)
DFCITC1573276
DoTSDT.103573378, DT.110891014, DT.535307
NIA Mouse Gene IndexU029872
EC3.4.17.10
Consensus CDS ProjectCCDS22327.1
International Mouse Knockout Project StatusCpe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037852 Ensembl Gene Model | MGI Sequence Detail 100483 C57BL/6J ±  kb
transcript ENSMUST00000048967 Ensembl | MGI Sequence Detail 2087 Not Applicable 
polypeptide ENSMUSP00000048555 Ensembl | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(970 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008969 Carboxypeptidase-like, regulatory domain
InterPro IPR014766 Carboxypeptidase, regulatory domain
InterPro IPR000834 Peptidase M14, carboxypeptidase A
Protein Ontology PR:000005804 carboxypeptidase E
References (Earliest) J:13651 Hummel KP, et al., fat = fat, Chr UN. Mouse News Lett. 1974;50:43
(Latest) J:206345 Cheng Y, et al., Carboxypeptidase E/NFalpha1: a new neurotrophic factor against oxidative stress-induced apoptotic cell death mediated by ERK and PI3-K/AKT pathways. PLoS One. 2013;8(8):e71578
All references(116)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-18763, MGD-MRK-2106, MGD-MRK-2107, MGD-MRK-9713, MGI:2142890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory