Dlx5
Gene Detail

Symbol Name ID

Dlx5 distal-less homeobox 5 MGI:101926

Feature Type

protein coding gene

Genetic Map

Chromosome 6

2.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:6877805-6882085 bp, - strand From VEGA annotation of GRCm38   4281 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dlx5

Human homologs

Human Homolog		DLX5, distal-less homeobox 5
NCBI Gene ID		1749
neXtProt AC		NX_P56178
Human Synonyms		SHFM1D
Human Chr (Location)		7q22; chr7:96649702-96654143 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DLX5

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mutants display multiple defects in craniofacial structures, including ears, nose, mandible and calvaria, and die shortly after birth, with some exhibiting exencephaly.

 
Human Diseases Modeled Using Mouse Dlx5 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	anatomical structure formation involved in morphogenesis, axon guidance, ...
Component	cytoplasm, nucleus
Function	DNA binding, HMG box domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (200 records)
Data Summary: Results (634)    Tissues (404)    Images (136)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	21
RNA in situ	567
In situ reporter (knock in)	1
Northern blot	2
RT-PCR	37
RNase protection	6

cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(1) cDNA(30) Primer pair(7) Other(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021177 (Evidence)
Ensembl Gene Model	ENSMUSG00000029755 (Evidence)
Entrez Gene	13395 (Evidence)
UniGene	4873
DFCI	TC1584528, TC1596772
DoTS	DT.101122016, DT.101364077, DT.485672, DT.87050939, DT.97359781
NIA Mouse Gene Index	U027033
Consensus CDS Project	CCDS19905.1
International Mouse Knockout Project Status	Dlx5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021177	VEGA Gene Model | MGI Sequence Detail	4281	C57BL/6J
transcript	OTTMUST00000050166	VEGA | MGI Sequence Detail	1423	Not Applicable
polypeptide	OTTMUSP00000023382	VEGA | MGI Sequence Detail	289	Not Applicable

All sequences(38) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022135	Distal-less-like homeobox protein, N-terminal domain
InterPro	IPR000047	Helix-turn-helix motif
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000006531	homeobox protein DLX-5

References

(Earliest) J:17176 Simeone A, et al., Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2250-4
(Latest) J:193110 Griffin JN, et al., Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1;374(1):185-97
All references(248)

Other accession IDs

MGD-MRK-18757, MGI:2141401