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Dlx5
Gene Detail
Symbol

Name
ID
Dlx5
distal-less homeobox 5
MGI:101926
Feature Type
protein coding gene
Genetic Map
Chromosome 6
2.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:6877805-6882085 bp, - strand
From VEGA annotation of GRCm38

  4281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DLX5
Gene Tree: Dlx5

Human
homologs
DLX5, distal-less homeobox 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1749
neXtProt AC: NX_P56178

Human Synonyms: SHFM1D

Human Chr (Location): 7q22; chr7:97020390-97024831 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DLX5

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Dlx5 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants display multiple defects in craniofacial structures, including ears, nose, mandible and calvaria, and die shortly after birth, with some exhibiting exencephaly.
 
Human Diseases Modeled in Mice Using Dlx5 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Dlx5 interacts with 172 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process anatomical structure formation involved in morphogenesis, axon guidance, ...
Component cytoplasm, nuclear chromatin, ...
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (229 records)
Data Summary: Results (717)    Tissues (435)    Images (189)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 44
RNA in situ 605
In situ reporter (knock in) 23
Northern blot 2
RT-PCR 37
RNase protection 6
cDNA source data(29)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA DLX5 ; Xenbase dlx5 ; ZFIN dlx5a    NEW 
Molecular
reagents
All nucleic(52) Genomic(1) cDNA(32) Primer pair(7) Other(12)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021177 (Evidence)
Ensembl Gene Model ENSMUSG00000029755 (Evidence)
Entrez Gene 13395 (Evidence)
UniGene 4873
DFCI TC1584528, TC1596772
DoTS DT.101122016, DT.101364077, DT.485672, DT.87050939, DT.97359781
NIA Mouse Gene Index U027033
Consensus CDS Project CCDS19905.1, CCDS59691.1
International Mouse Phenotyping Consortium Status Dlx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021177 VEGA Gene Model | MGI Sequence Detail 4281 C57BL/6J ±  kb
transcript OTTMUST00000050166 VEGA | MGI Sequence Detail 1423 Not Applicable 
polypeptide OTTMUSP00000023382 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022135 Distal-less-like homeobox protein, N-terminal domain
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006531 homeobox protein DLX-5
References
(Earliest) J:17176 Simeone A, et al., Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2250-4
(Latest) J:222399 Kitazawa T, et al., Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev Biol. 2015 Jun 15;402(2):162-74
All references(280)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-18757, MGI:2141401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory