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Dlx5
Gene Detail
 Symbol
Name
ID
Dlx5
distal-less homeobox 5
MGI:101926
Feature Type protein coding gene
Genetic Map
Chromosome 6
2.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:6877805-6882085 bp, - strand
From VEGA annotation of GRCm38

  4281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dlx5

Human
homologs
Human Homolog DLX5, distal-less homeobox 5
NCBI Gene ID 1749
neXtProt AC  NX_P56178
Human Synonyms  SHFM1D
Human Chr (Location)  7q22; chr7:97020390-97024831 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DLX5
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants display multiple defects in craniofacial structures, including ears, nose, mandible and calvaria, and die shortly after birth, with some exhibiting exencephaly.
 
Human Diseases Modeled Using Mouse Dlx5 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Dlx5 interacts with 172 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process anatomical structure formation involved in morphogenesis, axon guidance, ...
Component cytoplasm, nuclear chromatin, ...
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (213 records)
Data Summary: Results (716)    Tissues (426)    Images (187)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 44
RNA in situ 604
In situ reporter (knock in) 23
Northern blot 2
RT-PCR 37
RNase protection 6
cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) Genomic(1) cDNA(32) Primer pair(7) Other(12)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021177 (Evidence)
Ensembl Gene ModelENSMUSG00000029755 (Evidence)
Entrez Gene13395 (Evidence)
UniGene4873
DFCITC1584528, TC1596772
DoTSDT.101122016, DT.101364077, DT.485672, DT.87050939, DT.97359781
NIA Mouse Gene IndexU027033
Consensus CDS ProjectCCDS19905.1, CCDS59691.1
International Mouse Knockout Project StatusDlx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021177 VEGA Gene Model | MGI Sequence Detail 4281 C57BL/6J ±  kb
transcript OTTMUST00000050166 VEGA | MGI Sequence Detail 1423 Not Applicable 
polypeptide OTTMUSP00000023382 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022135 Distal-less-like homeobox protein, N-terminal domain
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006531 homeobox protein DLX-5
References (Earliest) J:17176 Simeone A, et al., Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2250-4
(Latest) J:210664 Restelli M, et al., DLX5, FGF8 and the Pin1 isomerase control DeltaNp63alpha protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations. Hum Mol Genet. 2014 Jul 15;23(14):3830-42
All references(264)
Other
accession IDs
MGD-MRK-18757, MGI:2141401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory