Ap2a2 MGI Mouse Gene Detail - MGI:101920 - adaptor-related protein complex 2, alpha 2 subunit

Ap2a2 Gene Detail

Symbol

Ap2a2
Name

adaptor-related protein complex 2, alpha 2 subunit
Synonyms

2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25

Feature Type

protein coding gene
IDs

MGI:101920
NCBI Gene: 11772
Gene Overview

MyGene.info: AP2A2

Sequence Map

Chr7:141562173-141633011 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

70839 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.94 cM
Mapping Data

5 experiments

Human Ortholog

AP2A2, adaptor related protein complex 2 alpha 2 subunit

Vertebrate Orthologs

9

Human Ortholog

AP2A2, adaptor related protein complex 2 alpha 2 subunit
Orthology source: HomoloGene, HGNC
Synonyms

ADTAB, CLAPA2, HIP9, HIP-9, HYPJ
Links

HGNC:562

NCBI Gene ID: 161

neXtProt AC: NX_O94973

UniProt: O94973
Chr Location

11p15.5; chr11:925809-1012245 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5335
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: AP2A2
Protein SuperFamily

adaptor protein complex AP-2, alpha subunit
Gene Tree

Ap2a2

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

63
Gene trapped

59
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Ap2a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available

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All GO Annotations

28
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1
Tissues

1
cDNA Data

213
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AP2A2

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Ap2a2 interacts with 222 markers (Mir1a-2, Mir1b, Mir17, ...) View All

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All Sequences

60
RefSeq

6
UniProt

6
CCDS

CCDS40188.1
UniGene

253090

			Length	Strain/Species	Flank
genomic	OTTMUSG00000055665	VEGA Gene Model \| MGI Sequence Detail	70839	C57BL/6J	± kb
transcript	OTTMUST00000137766	VEGA \| MGI Sequence Detail	4646	Not Applicable
polypeptide	OTTMUSP00000072508	VEGA \| MGI Sequence Detail	938	Not Applicable

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SNPs within 2kb

138 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000004100 AP-2 complex subunit alpha-2

(term hierarchy)
PDB

1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
InterPro Domains

IPR017104 Adaptor protein complex AP-2, alpha subunit

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain

IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain

IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal

IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain

IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain

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All nucleic 217

Genomic 1

cDNA 216

Microarray probesets 5

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MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324

Summaries

All 65

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 16
Earliest

J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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