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Ap2a2 Gene Detail
Summary
  • Symbol
    Ap2a2
  • Name
    adaptor-related protein complex 2, alpha 2 subunit
  • Synonyms
    2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25
  • Feature Type
    protein coding gene
  • IDs
    MGI:101920
    NCBI Gene: 11772
  • Gene Overview
    MyGene.info: AP2A2
Location & Maps
more
  • Sequence Map
    Chr7:141562173-141633011 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      70839 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.94 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    AP2A2, adaptor related protein complex 2 alpha 2 subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AP2A2, adaptor related protein complex 2 alpha 2 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADTAB, CLAPA2, HIP9, HIP-9, HYPJ
  • Links
    NCBI Gene ID: 161
    neXtProt AC: NX_O94973

  • Chr Location
    11p15.5; chr11:925809-1012245 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    63
  • Gene trapped
    59
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Ap2a2
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    213
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055665 VEGA Gene Model | MGI Sequence Detail 70839 C57BL/6J ±  kb
transcript OTTMUST00000137766 VEGA | MGI Sequence Detail 4646 Not Applicable  
polypeptide OTTMUSP00000072508 VEGA | MGI Sequence Detail 938 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    138 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004100 AP-2 complex subunit alpha-2
  • PDB
    1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
  • InterPro Domains
    IPR017104 Adaptor protein complex AP-2, alpha subunit
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
    IPR013038 Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
    IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
    IPR015873 Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
    IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
    IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
    IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Molecular
Reagents
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  • All nucleic 217
    Genomic 1
    cDNA 216

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324
References
more
  • Summaries
    All 56
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
  • Latest
    J:204152 Onishi K, et al., Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec 4;33(49):19071-85
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory