Ap2a2
Gene Detail

Symbol

Name
ID

Ap2a2
adaptor-related protein complex 2, alpha 2 subunit
MGI:101920

Synonyms

2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25

Feature Type

protein coding gene

Genetic Map

Chromosome 7
86.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr7:141562180-141633011 bp, + strand From NCBI annotation of GRCm38   70832 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:5335  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: adaptor protein complex AP-2, alpha subunit
Gene Tree: Ap2a2

Human
homologs

Human Homolog		AP2A2, adaptor-related protein complex 2, alpha 2 subunit
NCBI Gene ID		161
neXtProt AC		NX_O94973
Human Synonyms		ADTAB, CLAPA2, HIP9, HIP-9, HYPJ
Human Chr (Location)		11p15.5; chr11:925809-1012245 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(62) : Gene trapped(59) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Ap2a2 interacts with 223 markers (Mir1a-2, Mir1b, Mir17, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	endocytosis, intracellular protein transport, ...
Component	clathrin adaptor complex, coated pit, ...
Function	lipid binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

cDNA source data(213)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(217) Genomic(1) cDNA(216)
Microarray probesets(5)

Other database
links

Ensembl Gene Model	ENSMUSG00000002957 (Evidence)
Entrez Gene	11772 (Evidence)
UniGene	253090
DFCI	TC1720485, TC1571955, TC1641943
DoTS	DT.101207077, DT.101389327, DT.534641, DT.55125322
NIA Mouse Gene Index	U008965
PDB	1KYU, 1KYF, 1KYD, 1B9K, 1QTP, 1QTS, 2JKT, 2JKR, 1KY6, 3HS8, 1W80, 1KY7, 2VJ0
Consensus CDS Project	CCDS40188.1
International Mouse Knockout Project Status	Ap2a2

Sequences

Length	Strain/Species
genomic	11772	NCBI Gene Model | MGI Sequence Detail	70832	C57BL/6J
transcript	NM_007459	RefSeq | MGI Sequence Detail	4639	C57BL/6
polypeptide	P17427	UniProt | EBI | MGI Sequence Detail	938	Not Applicable

All sequences(57) RefSeq(6) UniProt(7)

Polymorphisms

SNPs within 2kb(138 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017104	Adaptor protein complex AP-2, alpha subunit
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR003164	Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
InterPro	IPR013038	Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
InterPro	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro	IPR015873	Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
InterPro	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro	IPR013041	Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology	PR:000004100	AP-2 complex subunit alpha-2

Graphical View of Protein Domain Structure

References

(Earliest) J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
(Latest) J:204152 Onishi K, et al., Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec 4;33(49):19071-85
All references(59)

Other
accession IDs

MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324