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Ap2a2
Gene Detail
 Symbol
Name
ID
Ap2a2
adaptor-related protein complex 2, alpha 2 subunit
MGI:101920
Synonyms 2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25
Feature Type protein coding gene
Genetic Map
Chromosome 7
86.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:141562180-141633011 bp, + strand
From NCBI annotation of GRCm38

  70832 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5335  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: adaptor protein complex AP-2, alpha subunit
Gene Tree: Ap2a2

Human
homologs
Human Homolog AP2A2, adaptor-related protein complex 2, alpha 2 subunit
NCBI Gene ID 161
neXtProt AC  NX_O94973
Human Synonyms  ADTAB, CLAPA2, HIP9, HIP-9, HYPJ
Human Chr (Location)  11p15.5; chr11:925809-1012245 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Gene trapped(59) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ap2a2 interacts with 223 markers (Mir1a-2, Mir1b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process endocytosis, intracellular protein transport, ...
Component clathrin adaptor complex, coated pit, ...
Function lipid binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
cDNA source data(213)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(217) Genomic(1) cDNA(216)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000002957 (Evidence)
Entrez Gene11772 (Evidence)
UniGene253090
DFCITC1571955, TC1641943, TC1720485
DoTSDT.101207077, DT.101389327, DT.534641, DT.55125322
NIA Mouse Gene IndexU008965
PDB1B9K, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 2JKR, 2JKT, 1KY6, 1KY7, 1W80, 2VJ0, 3HS8
Consensus CDS ProjectCCDS40188.1
International Mouse Knockout Project StatusAp2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11772 NCBI Gene Model | MGI Sequence Detail 70832 C57BL/6J ±  kb
transcript NM_007459 RefSeq | MGI Sequence Detail 4639 C57BL/6 
polypeptide P17427 UniProt | EBI | MGI Sequence Detail 938 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017104 Adaptor protein complex AP-2, alpha subunit
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
InterPro IPR013038 Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
InterPro IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro IPR015873 Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology PR:000004100 AP-2 complex subunit alpha-2
Graphical View of Protein Domain Structure
References (Earliest) J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
(Latest) J:204152 Onishi K, et al., Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec 4;33(49):19071-85
All references(55)
Other
accession IDs
MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory