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Ap2a2
Gene Detail
Symbol

Name
ID
Ap2a2
adaptor-related protein complex 2, alpha 2 subunit
MGI:101920
Synonyms
2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:141562180-141633011 bp, + strand
From NCBI annotation of GRCm38

  70832 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5335  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: AP2A2
Protein SuperFamily: adaptor protein complex AP-2, alpha subunit
Gene Tree: Ap2a2

Human
homologs
AP2A2, adaptor-related protein complex 2, alpha 2 subunit
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 161
neXtProt AC: NX_O94973

Human Synonyms: ADTAB, CLAPA2, HIP9, HIP-9, HYPJ

Human Chr (Location): 11p15.5; chr11:925809-1012245 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Gene trapped(59) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ap2a2 interacts with 222 markers (Mir1a-2, Mir1b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process endocytosis, intracellular protein transport, ...
Component clathrin adaptor complex, coated pit, ...
Function lipid binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 1
cDNA source data(213)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA AP2A2 ; Xenbase ap2a2    NEW 
Molecular
reagents
All nucleic(217) Genomic(1) cDNA(216)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000002957 (Evidence)
Entrez Gene 11772 (Evidence)
UniGene 253090
DFCI TC1720485, TC1641943, TC1571955
DoTS DT.534641, DT.101389327, DT.101207077, DT.55125322
NIA Mouse Gene Index U008965
PDB 2JKT, 2JKR, 1QTS, 1B9K, 1KYD, 1QTP, 1KYU, 1KYF, 1KY7, 1KY6, 1W80, 2VJ0, 3HS8
Consensus CDS Project CCDS40188.1
International Mouse Phenotyping Consortium Status Ap2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11772 NCBI Gene Model | MGI Sequence Detail 70832 C57BL/6J ±  kb
transcript NM_007459 RefSeq | MGI Sequence Detail 4639 C57BL/6 
polypeptide P17427 UniProt | EBI | MGI Sequence Detail 938 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017104 Adaptor protein complex AP-2, alpha subunit
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
InterPro IPR013038 Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
InterPro IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro IPR015873 Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology PR:000004100 AP-2 complex subunit alpha-2
Graphical View of Protein Domain Structure
References
(Earliest) J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
(Latest) J:204152 Onishi K, et al., Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec 4;33(49):19071-85
All references(58)
Other
accession IDs
MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory