Ap2a2 Gene Detail

Summary

• Symbol
  Ap2a2
• Name
  adaptor-related protein complex 2, alpha 2 subunit
• Synonyms
  2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25

• Feature Type
  protein coding gene
• IDs
  MGI:101920
  NCBI Gene: 11772
• Gene Overview
  MyGene.info: AP2A2
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr7:141562180-141633011 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 86.94 cM
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  138 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101920	protein coding gene	Chr7:141562173-141633011 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033238	protein coding gene	Chr7:146757358-146837286 (+)
A/J	MGP_AJ_G0033219	protein coding gene	Chr7:142564215-142636755 (+)
AKR/J	MGP_AKRJ_G0033152	protein coding gene	Chr7:146519515-146596177 (+)
BALB/cJ	MGP_BALBcJ_G0033220	protein coding gene	Chr7:142303193-142375560 (+)
C3H/HeJ	MGP_C3HHeJ_G0032935	protein coding gene	Chr7:146255407-146329189 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033732	protein coding gene	Chr7:152109311-152185786 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030705	protein coding gene	Chr7:143766334-143838515 (+)
CAST/EiJ	MGP_CASTEiJ_G0032265	protein coding gene	Chr7:138571138-138654044 (+)
CBA/J	MGP_CBAJ_G0032907	protein coding gene	Chr7:157272798-157360144 (+)
DBA/2J	MGP_DBA2J_G0033059	protein coding gene	Chr7:140507081-140578122 (+)
FVB/NJ	MGP_FVBNJ_G0033012	protein coding gene	Chr7:140419279-140489863 (+)
LP/J	MGP_LPJ_G0033154	protein coding gene	Chr7:148251312-148326662 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033045	protein coding gene	Chr7:157910118-157990693 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033751	protein coding gene	Chr7:145471922-145546527 (+)
PWK/PhJ	MGP_PWKPhJ_G0031969	protein coding gene	Chr7:133792182-133866131 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031815	protein coding gene	Chr7:132309916-132387440 (+)
WSB/EiJ	MGP_WSBEiJ_G0032375	protein coding gene	Chr7:146426225-146503856 (+)

Homology

• Human Ortholog
  AP2A2, adaptor related protein complex 2 subunit alpha 2

• Vertebrate Orthologs
  9

• Human Ortholog
  AP2A2, adaptor related protein complex 2 subunit alpha 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  ADTAB, CLAPA2, HIP9, HIP-9, HYPJ
• Links
  HGNC:562

  NCBI Gene ID: 161

  neXtProt AC: NX_O94973

  UniProt: O94973

  
  
• Chr Location
  11p15.5; chr11:925809-1012245 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 5335
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: AP2A2
• Protein SuperFamily
  adaptor protein complex AP-2, alpha subunit
• Gene Tree
  Ap2a2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from 2 alleles in 2 genetic backgrounds
  17 phenotype references
  

• All Mutations and Alleles
  64
• Endonuclease-mediated
  1
• Gene trapped
  59
• Radiation induced
  1
• Targeted
  3
• Genomic Mutations
  1 involving Ap2a2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  36 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

• All GO Annotations
  26
• GO References
  11

• External Resources
  FuncBase

Expression

• Assay Results
  1
• Tissues
  1
• cDNA Data
  214
• Literature Summary
  4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA AP2A2
  Xenbase ap2a2

Interactions

• Ap2a2 interacts with 222 markers (Mir1a-2, Mir1b, Mir17, ...) View All

Sequences &
Gene Models

• All Sequences
  69
• RefSeq
  6
• UniProt
  5
• CCDS
  CCDS40188.1
• UniGene
  253090

• Ensembl
  ENSMUSG00000002957 (Evidence)
• NCBI Gene
  11772

Representative Sequences			Length	Strain/Species
genomic	11772	NCBI Gene Model | MGI Sequence Detail	70832	C57BL/6J
transcript	NM_001357068	RefSeq | MGI Sequence Detail	4642	C57BL/6
polypeptide	P17427	UniProt | EBI | MGI Sequence Detail	938	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000004100 AP-2 complex subunit alpha-2
  (term hierarchy)
• PDB
  1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
• InterPro Domains
  IPR017104 Adaptor protein complex AP-2, alpha subunit
  IPR011989 Armadillo-like helical
  IPR016024 Armadillo-type fold
  IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
  IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
  IPR013041 Clathrin adaptor, appendage, Ig-like subdomain superfamily
  IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
  IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
  IPR012295 TBP domain superfamily

Molecular
Reagents

• All nucleic 218

  Genomic 1

  cDNA 217

  
  

  Microarray probesets 5

Other
Accession IDs

MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324

References

• Summaries
  All 71

  Developmental Gene Expression 4

  Gene Ontology 11

  Phenotypes 17
• Earliest
  J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
• Latest
  J:255150 Piccini A, et al., APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. Cell Rep. 2017 Dec 19;21(12):3596-3611

TSS for Ap2a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70013	Chr7:141562162-141562192 (+)	-3 bp
Tssr70014	Chr7:141562193-141562276 (+)	55 bp
Tssr70015	Chr7:141562285-141562296 (+)	111 bp
Tssr70016	Chr7:141613825-141613834 (+)	51,650 bp
Tssr70017	Chr7:141613838-141613845 (+)	51,662 bp
Tssr70020	Chr7:141632516-141632518 (+)	70,337 bp