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Ap2a2 Gene Detail
Summary
  • Symbol
    Ap2a2
  • Name
    adaptor-related protein complex 2, alpha 2 subunit
  • Synonyms
    2410074K14Rik, Adtab, alpha-adaptin C, alpha-C adaptin, L25
  • Feature Type
    protein coding gene
  • IDs
    MGI:101920
    NCBI Gene: 11772
  • Gene Overview
    MyGene.info: AP2A2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141562180-141633011 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.94 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101920
protein coding gene Chr7:141562173-141633011 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033238
protein coding gene Chr7:146757358-146837286 (+)
A/J MGP_AJ_G0033219
protein coding gene Chr7:142564215-142636755 (+)
AKR/J MGP_AKRJ_G0033152
protein coding gene Chr7:146519515-146596177 (+)
BALB/cJ MGP_BALBcJ_G0033220
protein coding gene Chr7:142303193-142375560 (+)
C3H/HeJ MGP_C3HHeJ_G0032935
protein coding gene Chr7:146255407-146329189 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033732
protein coding gene Chr7:152109311-152185786 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030705
protein coding gene Chr7:143766334-143838515 (+)
CAST/EiJ MGP_CASTEiJ_G0032265
protein coding gene Chr7:138571138-138654044 (+)
CBA/J MGP_CBAJ_G0032907
protein coding gene Chr7:157272798-157360144 (+)
DBA/2J MGP_DBA2J_G0033059
protein coding gene Chr7:140507081-140578122 (+)
FVB/NJ MGP_FVBNJ_G0033012
protein coding gene Chr7:140419279-140489863 (+)
LP/J MGP_LPJ_G0033154
protein coding gene Chr7:148251312-148326662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033045
protein coding gene Chr7:157910118-157990693 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033751
protein coding gene Chr7:145471922-145546527 (+)
PWK/PhJ MGP_PWKPhJ_G0031969
protein coding gene Chr7:133792182-133866131 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031815
protein coding gene Chr7:132309916-132387440 (+)
WSB/EiJ MGP_WSBEiJ_G0032375
protein coding gene Chr7:146426225-146503856 (+)



Homology
more
  • Human Ortholog
    AP2A2, adaptor related protein complex 2 subunit alpha 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AP2A2, adaptor related protein complex 2 subunit alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADTAB, CLAPA2, HIP9, HIP-9, HYPJ
  • Links
    NCBI Gene ID: 161
    neXtProt AC: NX_O94973
    UniProt: O94973

  • Chr Location
    11p15.5; chr11:925809-1012245 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11772 NCBI Gene Model | MGI Sequence Detail 70832 C57BL/6J ±  kb
    transcript NM_001357068 RefSeq | MGI Sequence Detail 4642 C57BL/6  
    polypeptide P17427 UniProt | EBI | MGI Sequence Detail 938 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 218
      Genomic 1
      cDNA 217

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18749, MGI:1354776, MGI:1920922, MGI:2142215, MGI:2142324
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
    • Latest
      J:255150 Piccini A, et al., APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. Cell Rep. 2017 Dec 19;21(12):3596-3611

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory