Ap2a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ap2a2
adaptor-related protein complex 2, alpha 2 subunit
MGI:101920

37 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ap2a2^{em1(IMPC)Wtsi}/Ap2a2⁺ C57BL/6N-Ap2a2^{em1(IMPC)Wtsi}/Wtsi	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased circulating LDL cholesterol level	J:211773
Ap2a2^{em1(IMPC)Wtsi}/Ap2a2^{em1(IMPC)Wtsi} C57BL/6N-Ap2a2^{em1(IMPC)Wtsi}/Wtsi	preweaning lethality, incomplete penetrance	J:211773
Ap2a2^tm1.1Momk/Ap2a2^tm1.1Momk Tg(Adipoq-cre)#Pesch/0 involves: C57BL/6J * C57BL/6N * FVB	abnormal brown adipose tissue morphology	J:297689
	abnormal energy homeostasis	J:297689
	abnormal mitochondrial biogenesis	J:297689
	abnormal mitochondrial physiology	J:297689
	abnormal white adipose tissue physiology	J:297689
	decreased brown adipose tissue amount	J:297689
	decreased circulating free fatty acids level	J:297689
	decreased circulating insulin level	J:297689
	decreased circulating leptin level	J:297689
	decreased epididymal fat pad weight	J:297689
	decreased fasting circulating glucose level	J:297689
	decreased fatty acid oxidation	J:297689
	decreased inflammatory response	J:297689
	decreased inguinal fat pad weight	J:297689
	decreased susceptibility to diet-induced hepatic steatosis	J:297689
	decreased susceptibility to diet-induced obesity	J:297689
	decreased white fat cell size	J:297689
	impaired adaptive thermogenesis	J:297689
	improved glucose tolerance	J:297689
	increased carbon dioxide production	J:297689
	increased energy expenditure	J:297689
	increased fat cell mitochondrial DNA content	J:297689
	increased fatty acid oxidation	J:297689
	increased insulin sensitivity	J:297689
	increased mitochondrial number	J:297689
	increased oxygen consumption	J:297689
Ap2a2^{tm1b(EUCOMM)Wtsi}/Ap2a2⁺ C57BL/6N-Ap2a2^{tm1b(EUCOMM)Wtsi}/Wtsi	increased circulating free fatty acids level	J:211773
Ap2a2^{tm1b(EUCOMM)Wtsi}/Ap2a2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Ap2a2^{tm1b(EUCOMM)Wtsi}/Wtsi	absent pinna reflex	J:211773
	decreased circulating fructosamine level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased circulating iron level	J:211773
	increased circulating LDL cholesterol level	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/05/2025 MGI 6.24