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Pla2g5 Gene Detail
Summary
  • Symbol
    Pla2g5
  • Name
    phospholipase A2, group V
  • Synonyms
    sPLA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101899
    NCBI Gene: 18784
  • Gene Overview
    MyGene.info: PLA2G5
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138799247-138863469 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    843 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101899
protein coding gene Chr4:138799244-138863482 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029004
protein coding gene Chr4:141585204-141655884 (-)
A/J MGP_AJ_G0028963
protein coding gene Chr4:135508353-135574554 (-)
AKR/J MGP_AKRJ_G0028915
protein coding gene Chr4:139386051-139451319 (-)
BALB/cJ MGP_BALBcJ_G0028987
protein coding gene Chr4:136184063-136249944 (-)
C3H/HeJ MGP_C3HHeJ_G0028701
protein coding gene Chr4:139759286-139826897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029428
protein coding gene Chr4:146591775-146680821 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026699
protein coding gene Chr4:128488825-128549295 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028666
protein coding gene Chr4:150816712-150895239 (-)
DBA/2J MGP_DBA2J_G0028815
protein coding gene Chr4:135891235-135957435 (-)
FVB/NJ MGP_FVBNJ_G0028782
protein coding gene Chr4:134920125-134987436 (-)
LP/J MGP_LPJ_G0028914
protein coding gene Chr4:141666031-141737891 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028808
protein coding gene Chr4:154771965-154840388 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029466
protein coding gene Chr4:139918202-139986774 (-)
PWK/PhJ MGP_PWKPhJ_G0027854
protein coding gene Chr4:132749215-132818785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027679
protein coding gene Chr4:135674161-135744726 (-)
WSB/EiJ MGP_WSBEiJ_G0028211
protein coding gene Chr4:140156113-140225785 (-)



Homology
more
  • Human Ortholog
    PLA2G5, phospholipase A2 group V
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PLA2G5, phospholipase A2 group V
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FRFB, GV-PLA2, hVPLA(2), PLA2-10
  • Links
    NCBI Gene ID: 5322
    neXtProt AC: NX_P39877
    UniProt: P39877

  • Chr Location
    1p36.13; chr1:20028350-20091901 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 5 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced acute zymosan-induced peritonitis and arachadonic acid metabolite release from stimulated peritoneal macrophages. Mice homozygous for a different knock-out allele exhibit reduced response to myocardial ischemia/reperfusion injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18784 NCBI Gene Model | MGI Sequence Detail 64223 C57BL/6J ±  kb
transcript NM_001122954 RefSeq | MGI Sequence Detail 2140 Not Specified  
polypeptide P97391 UniProt | EBI | MGI Sequence Detail 137 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 11

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-18726
References
more
  • Summaries
    All 69
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 32
  • Earliest
    J:30355 Dennis EA, Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem. 1994 May 6;269(18):13057-60
  • Latest
    J:248955 Silva-Filho JL, et al., Group V Secretory Phospholipase A2 Is Involved in Tubular Integrity and Sodium Handling in the Kidney. PLoS One. 2016;11(1):e0147785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory