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Pla2g5
Gene Detail
 Symbol
Name
ID
Pla2g5
phospholipase A2, group V
MGI:101899
Synonyms sPLA2
Feature Type protein coding gene
Genetic Map
Chromosome 4
70.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:138799244-138863482 bp, - strand
From VEGA annotation of GRCm38

  64239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:716  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: phospholipase A2
Gene Tree: Pla2g5

Human
homologs
Human Homolog PLA2G5, phospholipase A2, group V
NCBI Gene ID 5322
neXtProt AC  NX_P39877
Human Synonyms  FRFB, GV-PLA2, hVPLA(2), PLA2-10
Human Chr (Location)  1p36-p34; chr1:20059650-20091901 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLA2G5
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display reduced acute zymosan-induced peritonitis and arachadonic acid metabolite release from stimulated peritoneal macrophages. Mice homozygous for a different knock-out allele exhibit reduced response to myocardial ischemia/reperfusion injury.
 
Interactions
Pla2g5 interacts with 134 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process arachidonic acid secretion, leukotriene biosynthetic process, ...
Component cell surface, extracellular region, ...
Function calcium-dependent phospholipase A2 activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (643)    Tissues (156)    Images (59)
Theiler Stages: 22, 23, 27, 28
Assay TypeResults
RNA in situ 635
Northern blot 8
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(2) cDNA(10)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000010028 (Evidence)
Ensembl Gene ModelENSMUSG00000041193 (Evidence)
Entrez Gene18784 (Evidence)
DFCITC1580686, TC1655561, TC1663456, TC1694763
DoTSDT.101226814, DT.101723145, DT.40141766, DT.40149703
NIA Mouse Gene IndexU025691
EC3.1.1.4
Consensus CDS ProjectCCDS18834.1
International Mouse Knockout Project StatusPla2g5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010028 VEGA Gene Model | MGI Sequence Detail 64239 C57BL/6J ±  kb
transcript OTTMUST00000023327 VEGA | MGI Sequence Detail 1976 Not Applicable 
polypeptide OTTMUSP00000010664 VEGA | MGI Sequence Detail 137 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(12) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(847 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001211 Phospholipase A2
InterPro IPR013090 Phospholipase A2, active site
InterPro IPR016090 Phospholipase A2 domain
Protein Ontology PR:000012810 calcium-dependent phospholipase A2
References (Earliest) J:30355 Dennis EA, Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem. 1994 May 6;269(18):13057-60
(Latest) J:204757 Ohta S, et al., Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol. 2013 Jun 15;190(12):5927-38
All references(60)
Other
accession IDs
MGD-MRK-18726

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory