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Pla2g5 Gene Detail
Summary
  • Symbol
    Pla2g5
  • Name
    phospholipase A2, group V
  • Synonyms
    sPLA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101899
    NCBI Gene: 18784
  • Gene Overview
    MyGene.info: PLA2G5
Location & Maps
more
  • Sequence Map
    Chr4:138799244-138863482 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64239 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PLA2G5, phospholipase A2 group V
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PLA2G5, phospholipase A2 group V
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRFB, GV-PLA2, hVPLA(2), PLA2-10
  • Links
    NCBI Gene ID: 5322
    neXtProt AC: NX_P39877

  • Chr Location
    1p36-p34; chr1:20028339-20091901 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PLA2G5 associations

Human Disease Mouse Models
       Fleck Retina, Familial Benign; FRFB   OMIM: 228980
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 5 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Targeted
    4
  • Genomic Mutations
    3 involving Pla2g5
  • Incidental Mutations
Homozygous null mice display reduced acute zymosan-induced peritonitis and arachadonic acid metabolite release from stimulated peritoneal macrophages. Mice homozygous for a different knock-out allele exhibit reduced response to myocardial ischemia/reperfusion injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010028 VEGA Gene Model | MGI Sequence Detail 64239 C57BL/6J ±  kb
transcript OTTMUST00000023327 VEGA | MGI Sequence Detail 1976 Not Applicable  
polypeptide OTTMUSP00000010664 VEGA | MGI Sequence Detail 137 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    844 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 10

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-18726
References
more
  • Summaries
    All 60
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 29
  • Earliest
    J:30355 Dennis EA, Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem. 1994 May 6;269(18):13057-60
  • Latest
    J:232433 Murase R, et al., Group X Secreted Phospholipase A2 Releases omega3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem. 2016 Mar 25;291(13):6895-911

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory