Sequence Detail

ID/Version

P97391 Q9QZU6 (UniProt | EBI)

Last sequence update: 2001-12-05
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Phospholipase A2 group V; EC=3.1.1.4 {ECO:0000269|PubMed:14962950};AltName: Full=PLA2-10;AltName: Full=Phosphatidylcholine 2-acylhydrolase 5;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 137 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pla2g5	phospholipase A2, group V	46	101	2	14

Sequence references in MGI

J:31958 Tischfield JA, et al., Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. Genomics. 1996 Mar 15;32(3):328-33
J:74678 Koduri RS, et al., Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2). J Biol Chem. 2002 Feb 22;277(8):5849-57
J:110309 Balestrieri B, et al., Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. J Biol Chem. 2006 Mar 10;281(10):6691-8
J:147503 Balestrieri B, et al., Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans. J Immunol. 2009 Apr 15;182(8):4891-8
J:164305 Giannattasio G, et al., Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. J Immunol. 2010 Oct 1;185(7):4430-8
J:215319 Sato H, et al., The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. Cell Metab. 2014 Jul 1;20(1):119-32
J:236850 Boilard E, et al., A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis. EMBO Mol Med. 2010 May;2(5):172-87
J:277033 Yamaguchi M, et al., Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms. Mucosal Immunol. 2018 May;11(3):615-626
J:285014 Wooton-Kee CR, et al., Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):762-7