Thpo
Gene Detail

Symbol Name ID

Thpo thrombopoietin MGI:101875

Synonyms

Mpllg, myeloproliferative leukemia virus oncogene ligand, TPO, TPO-1, TPO-2, TPO-3, TPO-4

Feature Type

protein coding gene

Genetic Map

Chromosome 16

12.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr16:20725158-20734511 bp, - strand From VEGA annotation of GRCm38   9354 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:398  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: thrombopoietin
Gene Tree: Thpo

Human homologs

Human Homolog		THPO, thrombopoietin
NCBI Gene ID		7066
neXtProt AC		NX_P40225
Human Synonyms		MGDF, MKCSF, ML, MPLLG, THCYT1, TPO
Human Chr (Location)		3q27; chr3:184089773-184095932 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human THPO

Alleles and phenotypes

All alleles(9) : Targeted(5) Gene trapped(4)
 

Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cell proliferation, myeloid cell differentiation, ...
Component	extracellular region, extracellular space
Function	cytokine activity, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (63)    Tissues (35)    Images (15)
Theiler Stages: 9, 10, 12, 14, 16, 18, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	35
Western blot	7
RT-PCR	21

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(3) cDNA(13) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021017 (Evidence)
Ensembl Gene Model	ENSMUSG00000022847 (Evidence)
Entrez Gene	21832 (Evidence)
UniGene	3943
DFCI	TC1589410, TC1595733, TC1633233
DoTS	DT.101140603, DT.40158172, DT.91412531
NIA Mouse Gene Index	U036894
Consensus CDS Project	CCDS37292.1
International Mouse Knockout Project Status	Thpo

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021017	VEGA Gene Model | MGI Sequence Detail	9354	C57BL/6J
transcript	OTTMUST00000049685	VEGA | MGI Sequence Detail	1712	Not Applicable
polypeptide	OTTMUSP00000023070	VEGA | MGI Sequence Detail	356	Not Applicable

All sequences(28) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001323	Erythropoietin/thrombopoeitin
InterPro	IPR019767	Erythropoietin/thrombopoeitin, conserved site
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR003978	Thrombopoeitin
Protein Ontology	PR:000016318	thrombopoietin

References

(Earliest) J:18896 Lok S, et al., Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo [see comments]. Nature. 1994 Jun 16;369(6481):565-8
(Latest) J:174962 Sugiyama D, et al., Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production. Biochem Biophys Res Commun. 2011 Jul 1;410(2):301-6
All references(75)

Other accession IDs

MGD-MRK-16629, MGD-MRK-18701