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Thpo
Gene Detail
Symbol

Name
ID
Thpo
thrombopoietin
MGI:101875
Synonyms
Mpllg, myeloproliferative leukemia virus oncogene ligand, TPO, TPO-1, TPO-2, TPO-3, TPO-4
Feature Type
protein coding gene
Genetic Map
Chromosome 16
12.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr16:20725158-20734511 bp, - strand
From VEGA annotation of GRCm38

  9354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:398  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: THPO
Protein SuperFamily: thrombopoietin
Gene Tree: Thpo

Human
homologs
THPO, thrombopoietin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7066
neXtProt AC: NX_P40225

Human Synonyms: MGDF, MKCSF, ML, MPLLG, THCYT1, TPO

Human Chr (Location): 3q27; chr3:184371935-184379688 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human THPO

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.
 
Interactions
Thpo interacts with 49 markers (Mir19a, Mir22, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell proliferation, myeloid cell differentiation, ...
Component extracellular region, extracellular space
Function cytokine activity, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (63)    Tissues (36)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
Western blot 7
RT-PCR 21
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100489048    NEW 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(13) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021017 (Evidence)
Ensembl Gene Model ENSMUSG00000022847 (Evidence)
Entrez Gene 21832 (Evidence)
UniGene 3943
DFCI TC1633233, TC1595733, TC1589410
DoTS DT.101140603, DT.40158172, DT.91412531
NIA Mouse Gene Index U036894
Consensus CDS Project CCDS37292.1
International Mouse Phenotyping Consortium Status Thpo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021017 VEGA Gene Model | MGI Sequence Detail 9354 C57BL/6J ±  kb
transcript OTTMUST00000049686 VEGA | MGI Sequence Detail 1587 Not Applicable 
polypeptide OTTMUSP00000023071 VEGA | MGI Sequence Detail 356 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(20) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001323 Erythropoietin/thrombopoeitin
InterPro IPR019767 Erythropoietin/thrombopoeitin, conserved site
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR003978 Thrombopoeitin
Protein Ontology PR:000016318 thrombopoietin
References
(Earliest) J:18896 Lok S, et al., Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo [see comments]. Nature. 1994 Jun 16;369(6481):565-8
(Latest) J:220785 Sangkhae V, et al., The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm. Blood. 2014 Dec 18;124(26):3956-63
All references(79)
Other
accession IDs
MGD-MRK-16629, MGD-MRK-18701

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory