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Thpo Gene Detail
Summary
  • Symbol
    Thpo
  • Name
    thrombopoietin
  • Synonyms
    Mpllg, myeloproliferative leukemia virus oncogene ligand, TPO, TPO-1, TPO-2, TPO-3, TPO-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:101875
    NCBI Gene: 21832
Location & Maps
more
  • Sequence Map
    Chr16:20725158-20734511 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9354 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    THPO, thrombopoietin
  • Vertebrate Orthologs
    7
  • Human Ortholog
    THPO, thrombopoietin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MGDF, MKCSF, ML, MPLLG, THCYT1, TPO
  • Links
    NCBI Gene ID: 7066
    neXtProt AC: NX_P40225

  • Chr Location
    3q27; chr3:184371935-184379688 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human THPO associations

Human Disease Mouse Models
       Thrombocythemia 1; THCYT1   OMIM: 187950
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    4
  • Targeted
    6
  • Incidental Mutations
    APF
Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021017 VEGA Gene Model | MGI Sequence Detail 9354 C57BL/6J ±  kb
transcript OTTMUST00000049686 VEGA | MGI Sequence Detail 1587 Not Applicable  
polypeptide OTTMUSP00000023071 VEGA | MGI Sequence Detail 356 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 19
    Genomic 3
    cDNA 13
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16629, MGD-MRK-18701
References
more
  • Summaries
    All 78
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 24
  • Earliest
    J:18896 Lok S, et al., Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo [see comments]. Nature. 1994 Jun 16;369(6481):565-8
  • Latest
    J:224848 Wu Z, et al., TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells. Cell Stem Cell. 2015 Jul 2;17(1):47-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory