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Usp15 Gene Detail
Summary
  • Symbol
    Usp15
  • Name
    ubiquitin specific peptidase 15
  • Synonyms
    4921514G19Rik, E430033I05Rik, Gcap18, mKIAA0529
  • Feature Type
    protein coding gene
  • IDs
    MGI:101857
    NCBI Gene: 14479
  • Gene Overview
    MyGene.info: USP15
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:123105006-123196995 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 72.31 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    771 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101857
protein coding gene Chr10:123105006-123197019 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017792
protein coding gene Chr10:126463297-126551026 (-)
A/J MGP_AJ_G0017767
protein coding gene Chr10:121403539-121490446 (-)
AKR/J MGP_AKRJ_G0017730
protein coding gene Chr10:125040917-125127689 (-)
BALB/cJ MGP_BALBcJ_G0017731
protein coding gene Chr10:121831424-121918695 (-)
C3H/HeJ MGP_C3HHeJ_G0017555
protein coding gene Chr10:125241917-125329356 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018186
protein coding gene Chr10:130730358-130817223 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015866
protein coding gene Chr10:115663320-115752633 (-)
CAST/EiJ MGP_CASTEiJ_G0017115
protein coding gene Chr10:125647786-125743846 (-)
CBA/J MGP_CBAJ_G0017524
protein coding gene Chr10:136076268-136163055 (-)
DBA/2J MGP_DBA2J_G0017630
protein coding gene Chr10:120537427-120624510 (-)
FVB/NJ MGP_FVBNJ_G0017625
protein coding gene Chr10:119518491-119602450 (-)
LP/J MGP_LPJ_G0017704
protein coding gene Chr10:126999322-127083406 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017653
protein coding gene Chr10:138563921-138653498 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018226
protein coding gene Chr10:125088994-125173859 (-)
PWK/PhJ MGP_PWKPhJ_G0016900
protein coding gene Chr10:120658544-120748711 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016692
protein coding gene Chr10:123999611-124080248 (-)
WSB/EiJ MGP_WSBEiJ_G0017176
protein coding gene Chr10:125267246-125351614 (-)



Homology
more
  • Human Ortholog
    USP15, ubiquitin specific peptidase 15
  • Vertebrate Orthologs
    9
  • Human Ortholog
    USP15, ubiquitin specific peptidase 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UNPH-2, UNPH4
  • Links
    NCBI Gene ID: 9958
    neXtProt AC: NX_Q9Y4E8
    UniProt: Q9Y4E8

  • Chr Location
    12q14.1; chr12:62260340-62409721 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or ENU induced allele exhibit resistance to pathological neuroinflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020124 Ensembl Gene Model | MGI Sequence Detail 91990 C57BL/6J ±  kb
transcript ENSMUST00000220377 Ensembl | MGI Sequence Detail 11525 Not Applicable  
polypeptide ENSMUSP00000151244 Ensembl | MGI Sequence Detail 981 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017151 ubiquitin carboxyl-terminal hydrolase 15
  • EC
  • InterPro Domains
    IPR035927 DUSP-like superfamily
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
    IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
    IPR029346 Ubiquitin carboxyl-terminal hydrolase, C-terminal
    IPR028134 Ubiquitin carboxyl-terminal hydrolase USP4
    IPR029071 Ubiquitin-like domain superfamily
    IPR028135 Ubiquitin-like domain, USP-type
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
Molecular
Reagents
less
  • All nucleic 27
    cDNA 27

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-18681, MGI:1918171, MGI:2143588
References
more
  • Summaries
    All 48
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
  • Latest
    J:259382 Torre S, et al., USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol. 2017 Jan;18(1):54-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory