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Mcm3 Gene Detail
Summary
  • Symbol
    Mcm3
  • Name
    minichromosome maintenance complex component 3
  • Synonyms
    Mcmd, P1, p1.m
  • Feature Type
    protein coding gene
  • IDs
    MGI:101845
    NCBI Gene: 17215
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:20873192-20890536 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 6.50 cM, cytoband A3-A5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    808 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101845
 protein coding gene Chr1:20873188-20890536 (-)
129S1/SvImJ ENSMUSG00200018487
 protein coding gene Chr1:18272593-18290087 (-)
A/J ENSMUSG00195027393
 protein coding gene Chr1:18043105-18060604 (-)
AKR/J ENSMUSG00220008085
 protein coding gene Chr1:18086782-18104279 (-)
BALB/cJ ENSMUSG00180022979
 protein coding gene Chr1:18109344-18126843 (-)
C3H/HeJ ENSMUSG00175000089
 protein coding gene Chr1:18038658-18056156 (-)
C57BL/6NJ ENSMUSG00215008777
 protein coding gene Chr1:18123527-18140871 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013984
 protein coding gene Chr1:16345992-16363884 (-)
CAST/EiJ ENSTCUG00005022011
 protein coding gene Chr1:18342583-18360333 (-)
CBA/J ENSMUSG00210002751
 protein coding gene Chr1:17915012-17932510 (-)
DBA/2J ENSMUSG00185003797
 protein coding gene Chr1:18959257-18976755 (-)
FVB/NJ ENSMUSG00205015663
 protein coding gene Chr1:18039799-18057299 (-)
JF1/MsJ ENSUMUG00000011902
 protein coding gene Chr1:18168184-18185443 (-)
LP/J ENSMUSG00230018802
 protein coding gene Chr1:18963324-18981637 (-)
NOD/ShiLtJ ENSMUSG00190024540
 protein coding gene Chr1:18020821-18038425 (-)
NZO/HlLtJ ENSMUSG00225000508
 protein coding gene Chr1:22338703-22356201 (-)
PWK/PhJ ENSLUMG00010021505
 protein coding gene Chr1:17800789-17818024 (-)
SPRET/EiJ ENSMSPG00010024666
 protein coding gene Chr1:18689897-18707431 (-)
WSB/EiJ ENSIUOG00005011808
 protein coding gene Chr1:18007779-18025275 (-)



Homology
more
  • Human Ortholog
    MCM3, minichromosome maintenance complex component 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCM3, minichromosome maintenance complex component 3
  • Synonyms
    HCC5, P1.h, P1-MCM3, RLFB
  • Links
    NCBI Gene ID: 4172
    UniProt: P25205

  • Chr Location
    6p12.2; chr6:52264011-52284881 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null or hypomorph alleles exhibit prenatal lethality. Fetal mice homozygous for a hypomorphic allele display anemia and replicative stress during fetal erythropoiesis. Mice heterozygous for null or hypomorph alleles display increased incidence of lymphomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    687
  • Tissues
    37
  • cDNA Data
    320
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041859 Ensembl Gene Model | MGI Sequence Detail 17345 C57BL/6J ±  kb
    transcript ENSMUST00000053266 Ensembl | MGI Sequence Detail 3031 Not Applicable  
    polypeptide ENSMUSP00000059192 Ensembl | MGI Sequence Detail 812 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 325
      Genomic 2
      cDNA 320
      Primer pair 3
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-18667, MGI:2138404, MGI:2138691
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 18
      Gene Ontology 12
      Phenotypes 10
    • Earliest
      J:20884 Thommes P, et al., Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. Nucleic Acids Res. 1992 Mar 11;20(5):1069-74
    • Latest
      J:381624 Koit S, et al., A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate. J Biol Chem. 2025 Mar 14;301(4):108408
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory