About   Help   FAQ
Mcm3
Gene Detail
 Symbol
Name
ID
Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
MGI:101845
Synonyms Mcmd, P1, p1.m
Feature Type protein coding gene
Genetic Map
Chromosome 1
6.50 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:20802968-20820312 bp, - strand
From VEGA annotation of GRCm38

  17345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1791  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: replication licensing factor MCM3
Gene Tree: Mcm3

Human
homologs
Human Homolog MCM3, minichromosome maintenance complex component 3
NCBI Gene ID 4172
neXtProt AC  NX_P25205
Human Synonyms  HCC5, P1.h, P1-MCM3, RLFB
Human Chr (Location)  6p12; chr6:52264014-52284881 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.
 
Interactions
Mcm3 interacts with 124 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell cycle, DNA replication, ...
Component centrosome, cytoplasm, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (75)    Tissues (30)    Images (22)
Theiler Stages: 14, 15, 17, 19, 20, 22, 23, 24
Assay TypeResults
RNA in situ 73
RT-PCR 2
cDNA source data(319)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(322) Genomic(2) cDNA(319) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000048358 (Evidence)
Ensembl Gene ModelENSMUSG00000041859 (Evidence)
Entrez Gene17215 (Evidence)
UniGene4502
DFCITC1573172, TC1640743
DoTSDT.101309284, DT.101738781, DT.55127186, DT.94239857, DT.94386083
NIA Mouse Gene IndexU021161
EC3.6.4.12
Consensus CDS ProjectCCDS14843.1
International Mouse Knockout Project StatusMcm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048358 VEGA Gene Model | MGI Sequence Detail 17345 C57BL/6J ±  kb
transcript OTTMUST00000124003 VEGA | MGI Sequence Detail 3031 Not Applicable 
polypeptide OTTMUSP00000067560 VEGA | MGI Sequence Detail 812 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(242 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR008046 DNA replication licensing factor Mcm3
InterPro IPR018525 Mini-chromosome maintenance, conserved site
InterPro IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010243 DNA replication licensing factor MCM3
References (Earliest) J:20884 Thommes P, et al., Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. Nucleic Acids Res. 1992 Mar 11;20(5):1069-74
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(53)
Other
accession IDs
MGD-MRK-18667, MGI:2138404, MGI:2138691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory