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Mcm3 Gene Detail
Summary
  • Symbol
    Mcm3
  • Name
    minichromosome maintenance complex component 3
  • Synonyms
    Mcmd, P1, p1.m
  • Feature Type
    protein coding gene
  • IDs
    MGI:101845
    NCBI Gene: 17215
  • Gene Overview
    MyGene.info: MCM3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:20803014-20820213 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 6.50 cM, cytoband A3-A5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    239 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101845
protein coding gene Chr1:20802968-20820312 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015872
protein coding gene Chr1:18428077-18445571 (-)
A/J MGP_AJ_G0015853
protein coding gene Chr1:18210023-18227521 (-)
AKR/J MGP_AKRJ_G0015812
protein coding gene Chr1:18242872-18260367 (-)
BALB/cJ MGP_BALBcJ_G0015809
protein coding gene Chr1:17903018-17920516 (-)
C3H/HeJ MGP_C3HHeJ_G0015643
protein coding gene Chr1:18266621-18284116 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016263
protein coding gene Chr1:19295246-19312590 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013984
protein coding gene Chr1:16345992-16363884 (-)
CAST/EiJ MGP_CASTEiJ_G0015224
protein coding gene Chr1:18360826-18379527 (-)
CBA/J MGP_CBAJ_G0015616
protein coding gene Chr1:19731947-19749444 (-)
DBA/2J MGP_DBA2J_G0015715
protein coding gene Chr1:17702747-17720241 (-)
FVB/NJ MGP_FVBNJ_G0015720
protein coding gene Chr1:17466350-17483848 (-)
LP/J MGP_LPJ_G0015787
protein coding gene Chr1:18653756-18671248 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015738
protein coding gene Chr1:20685284-20702762 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016310
protein coding gene Chr1:18217344-18234839 (-)
PWK/PhJ MGP_PWKPhJ_G0015008
protein coding gene Chr1:17444916-17462151 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014789
protein coding gene Chr1:18316758-18334291 (-)
WSB/EiJ MGP_WSBEiJ_G0015287
protein coding gene Chr1:18150615-18168106 (-)



Homology
more
  • Human Ortholog
    MCM3, minichromosome maintenance complex component 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCM3, minichromosome maintenance complex component 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCC5, P1.h, P1-MCM3, RLFB
  • Links
    NCBI Gene ID: 4172
    neXtProt AC: NX_P25205
    UniProt: P25205

  • Chr Location
    6p12.2; chr6:52264014-52284881 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null or hypomorph alleles exhibit prenatal lethality. Fetal mice homozygous for a hypomorphic allele display anemia and replicative stress during fetal erythropoiesis. Mice heterozygous for null or hypomorph alleles display increased incidence of lymphomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17215 NCBI Gene Model | MGI Sequence Detail 17200 C57BL/6J ±  kb
    transcript NM_008563 RefSeq | MGI Sequence Detail 3031 C57BL/6  
    polypeptide P25206 UniProt | EBI | MGI Sequence Detail 812 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 323
      Genomic 2
      cDNA 320
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-18667, MGI:2138404, MGI:2138691
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 13
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:20884 Thommes P, et al., Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. Nucleic Acids Res. 1992 Mar 11;20(5):1069-74
    • Latest
      J:241732 O'Driscoll M, The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery. J Pathol. 2017 Jan;241(2):192-207

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory