Mcm3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mcm3
minichromosome maintenance complex component 3
MGI:101845

25 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ involves: 129P2/OlaHsd * C3HeB/FeJ	abnormal erythrocyte morphology	J:165667
	chromosomal instability	J:165667
Mcm3^{Gt(RRR002)Byg}/Mcm3^{Gt(RRR002)Byg} involves: 129P2/OlaHsd * C3HeB/FeJ	prenatal lethality, complete penetrance	J:165667
Mcm3^tm1.1Geno/Mcm3⁺ involves: 129S2/SvPas * C57BL/6	decreased tumor latency	J:227638
	increased lymphoma incidence	J:227638
	increased metastatic potential	J:227638
	increased tumor incidence	J:227638
	premature death	J:227638
Mcm3^tm1.1Geno/Mcm3^tm1.1Geno involves: 129S2/SvPas * C57BL/6	abnormal cell cycle	J:227638
	abnormal erythrocyte morphology	J:227638
	abnormal erythropoiesis	J:227638
	abnormal liver physiology	J:227638
	abnormal proerythroblast morphology	J:227638
	abnormal reticulocyte cell number	J:227638
	decreased DNA replication	J:227638
	decreased fetal derived definitive erythrocyte cell number	J:227638
	decreased fetal size	J:227638
	decreased hematocrit	J:227638
	decreased hematopoietic stem cell proliferation	J:227638
	decreased hemoglobin content	J:227638
	increased apoptosis	J:227638
	increased erythroblast number	J:227638
	increased hematopoietic stem cell number	J:227638
	pallor	J:227638
	perinatal lethality, incomplete penetrance	J:227638
Mcm3^tm1.1Geno/Mcm3^tm1.1Geno involves: 129S2/SvPas * C57BL/6 * CD-1	prenatal lethality, incomplete penetrance	J:227638
Mcm3^tm1.2Geno/Mcm3⁺ involves: 129S2/SvPas * C57BL/6	decreased tumor latency	J:227638
	increased lymphoma incidence	J:227638
	increased metastatic potential	J:227638
	increased tumor incidence	J:227638
	premature death	J:227638
Mcm3^tm1.2Geno/Mcm3^tm1.2Geno involves: 129S2/SvPas * C57BL/6	prenatal lethality, complete penetrance	J:227638

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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