About   Help   FAQ
Traf2 Gene Detail
Summary
  • Symbol
    Traf2
  • Name
    TNF receptor-associated factor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101835
    NCBI Gene: 22030
  • Gene Overview
    MyGene.info: TRAF2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:25517982-25546940 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28959 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.32 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRAF2, TNF receptor associated factor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TRAF2, TNF receptor associated factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MGC:45012, RNF117, TRAP, TRAP3
  • Links
    NCBI Gene ID: 7186
    neXtProt AC: NX_Q12933
    UniProt: Q12933

  • Chr Location
    9q34.3; chr9:136881776-136926615 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 8 genetic backgrounds
    22 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Increased lethaltiy is observed with homozygous null mice. Offspring are runted and exhibit atrophic thymii and spleens with reduced numbers of lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012123 VEGA Gene Model | MGI Sequence Detail 28959 C57BL/6J ±  kb
    transcript OTTMUST00000028941 VEGA | MGI Sequence Detail 2151 Not Applicable  
    polypeptide OTTMUSP00000013079 VEGA | MGI Sequence Detail 508 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      160 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 63
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18656, MGI:2138907
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 26
      Phenotypes 44
    • Earliest
      J:19898 Rothe M, et al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994 Aug 26;78(4):681-92
    • Latest
      J:251911 Hu M, et al., Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. Mol Cell. 2017 Apr 6;66(1):141-153.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory