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Traf2 Gene Detail
Summary
  • Symbol
    Traf2
  • Name
    TNF receptor-associated factor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101835
    NCBI Gene: 22030
  • Gene Overview
    MyGene.info: TRAF2
Location & Maps
more
  • Sequence Map
    Chr2:25517982-25546940 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28959 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.32 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRAF2, TNF receptor associated factor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TRAF2, TNF receptor associated factor 2
    Orthology source: HomoloGene
  • Synonyms
    MGC:45012, TRAP, TRAP3
  • Links
    NCBI Gene ID: 7186
    neXtProt AC: NX_Q12933

  • Chr Location
    9q34; chr9:136881933-136926621 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 4 alleles in 8 genetic backgrounds
    22 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Increased lethaltiy is observed with homozygous null mice. Offspring are runted and exhibit atrophic thymii and spleens with reduced numbers of lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012123 VEGA Gene Model | MGI Sequence Detail 28959 C57BL/6J ±  kb
transcript OTTMUST00000028941 VEGA | MGI Sequence Detail 2151 Not Applicable  
polypeptide OTTMUSP00000013079 VEGA | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    160 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 65
    Genomic 1
    cDNA 63
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-18656, MGI:2138907
References
more
  • Summaries
    All 112
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 24
    Phenotypes 40
  • Earliest
    J:19898 Rothe M, et al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994 Aug 26;78(4):681-92
  • Latest
    J:232978 Yeung AT, et al., Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function. Sci Rep. 2015;5:8908

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory