Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables CD40 receptor binding activity and signaling adaptor activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to nitric oxide; regulation of JNK cascade; and regulation of immunoglobulin production. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; liver; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF receptor associated factor 2).