About   Help   FAQ
Fmn1
Gene Detail
Symbol

Name
ID
Fmn1
formin 1
MGI:101815
Synonyms
Fmn, formin-1, ld, limb deformity
Feature Type
protein coding gene
Genetic Map
Chromosome 2
57.30 cM, cytoband C1-qter
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr2:113327771-113709855 bp, + strand
From VEGA annotation of GRCm38

  382085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 western clawed frog

Gene Tree: Fmn1

Human
homologs
Human Homolog FMN1, formin 1
NCBI Gene ID 342184
neXtProt AC  NX_Q68DA7
Human Synonyms  FMN, LD
Human Chr (Location)  15q13.3; chr15:32765544-33194733 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Radiation induced(1) Spontaneous(3) Targeted(9) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for spontaneous, irradiation-induced, and transgene-insertional mutations show severe syndactyly and oligodactyly of the feet, abnormal long bones (including radius-ulna fusions), and reduced or absent kidneys. Many mutants survive and breed.
 
Interactions
Fmn1 interacts with 557 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin nucleation, dendrite morphogenesis, ...
Component actin filament, cell junction, ...
Function actin binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (140)    Tissues (58)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
Northern blot 40
RT-PCR 27
RNase protection 64
cDNA source data(58)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(91) Genomic(22) cDNA(60) Primer pair(5) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015195 (Evidence)
Ensembl Gene ModelENSMUSG00000044042 (Evidence)
Entrez Gene14260 (Evidence)
UniGene4938
DFCITC1586718, TC1596679, TC1718235, TC1653660
DoTSDT.91336660, DT.94180440, DT.91337235, DT.94123874, DT.110722849, DT.50315777, DT.55119737, DT.101318492, DT.101152765, DT.91336659
NIA Mouse Gene IndexU002259
PDB2RM0, 2RLY, 2JUP
Consensus CDS ProjectCCDS16559.1, CCDS38199.1, CCDS71112.1, CCDS71113.1
International Mouse Knockout Project StatusFmn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015195 VEGA Gene Model | MGI Sequence Detail 382085 C57BL/6J ±  kb
transcript OTTMUST00000036014 VEGA | MGI Sequence Detail 4967 Not Applicable 
polypeptide OTTMUSP00000016180 VEGA | MGI Sequence Detail 1466 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(19) UniProt(15)
Polymorphisms
All PCR and RFLP(16) : PCR(1) RFLP(15) SNPs within 2kb(2352 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015425 Actin-binding FH2
InterPro IPR001265 Formin
Protein Ontology PR:000007569 formin-1
References
(Earliest) J:22158 Cupp MB, Severe appendicular abnormality. Mouse News Lett. 1958;19:37
(Latest) J:213598 Hu J, et al., Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Hum Mol Genet. 2014 Sep 1;23(17):4663-73
All references(81)
Other
accession IDs
MGD-MRK-11761, MGD-MRK-18633, MGI:2139439

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory