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Fmn1
Gene Detail
Symbol

Name
ID
Fmn1
formin 1
MGI:101815
Synonyms
Fmn, formin-1, ld, limb deformity
Feature Type
protein coding gene
Genetic Map
Chromosome 2
57.30 cM, cytoband C1-qter
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr2:113327771-113709855 bp, + strand
From VEGA annotation of GRCm38

  382085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 western clawed frog

Human
homologs
Human Homolog   FMN1, formin 1
NCBI Gene ID 342184
neXtProt AC  NX_Q68DA7
Human Synonyms  FMN, LD
Human Chr (Location)  15q13.3; chr15:32765544-33194784 (-)  GRCh38.p2
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Radiation induced(1) Spontaneous(3) Targeted(9) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for spontaneous, irradiation-induced, and transgene-insertional mutations show severe syndactyly and oligodactyly of the feet, abnormal long bones (including radius-ulna fusions), and reduced or absent kidneys. Many mutants survive and breed.
 
Interactions
Fmn1 interacts with 556 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin nucleation, dendrite morphogenesis, ...
Component actin filament, cell junction, ...
Function actin binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (140)    Tissues (58)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
Northern blot 40
RT-PCR 27
RNase protection 64
cDNA source data(58)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(91) Genomic(22) cDNA(60) Primer pair(5) Other(4)
Microarray probesets(6)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015195 VEGA Gene Model | MGI Sequence Detail 382085 C57BL/6J ±  kb
transcript OTTMUST00000036014 VEGA | MGI Sequence Detail 4967 Not Applicable 
polypeptide OTTMUSP00000016180 VEGA | MGI Sequence Detail 1466 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(30) UniProt(8)
Polymorphisms
All PCR and RFLP(16) : PCR(1) RFLP(15) SNPs within 2kb(2352 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015425 Actin-binding FH2
InterPro IPR001265 Formin
Protein Ontology PR:000007569 formin-1
References
(Earliest) J:22158 Cupp MB, Severe appendicular abnormality. Mouse News Lett. 1958;19:37
(Latest) J:213598 Hu J, et al., Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Hum Mol Genet. 2014 Sep 1;23(17):4663-73
All references(81)
Other
accession IDs
MGD-MRK-11761, MGD-MRK-18633, MGI:2139439

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory