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Lig1
Gene Detail
 Symbol
Name
ID
Lig1
ligase I, DNA, ATP-dependent
MGI:101789
Synonyms LigI, mLigI
Feature Type protein coding gene
Genetic Map
Chromosome 7
7.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:13277283-13311433 bp, + strand
From VEGA annotation of GRCm38

  34151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ATP-dependent DNA ligase, eukaryotic type
Gene Tree: Lig1

Human
homologs
Human Homolog LIG1, ligase I, DNA, ATP-dependent
NCBI Gene ID 3978
neXtProt AC  NX_P18858
Human Chr (Location)  19q13.2-q13.3; chr19:48115445-48170603 (-)  GRCh38
Alleles
and
phenotypes
All alleles(21) : Targeted(4) Gene trapped(16) Chemically induced(1)
 
Mice homozygous for a null allele exhibit impaired fetal hematopoiesis, develop anemia, and die by E16.5.
 
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell cycle, cell division, ...
Component chromosome, Golgi apparatus, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (229)    Tissues (167)    Images (38)
Theiler Stages: 1, 2, 3, 4, 22, 23, 26, 28
Assay TypeResults
RNA in situ 221
RT-PCR 8
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030683 (Evidence)
Ensembl Gene ModelENSMUSG00000056394 (Evidence)
Entrez Gene16881 (Evidence)
DFCITC1573061
DoTSDT.101307261, DT.532319, DT.94407457
EC6.5.1.1
International Mouse Knockout Project StatusLig1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030683 VEGA Gene Model | MGI Sequence Detail 34151 C57BL/6J ±  kb
transcript OTTMUST00000117791 VEGA | MGI Sequence Detail 1053 Not Applicable 
polypeptide OTTMUSP00000065817 VEGA | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(8)
Polymorphisms RFLP(3) : SNPs within 2kb(219 from dbSNP Build 137)    SNPs within 2kb including multiple locations(229)
Protein-related
information
ResourceIDDescription
InterPro IPR000977 DNA ligase, ATP-dependent
InterPro IPR012310 DNA ligase, ATP-dependent, central
InterPro IPR016059 DNA ligase, ATP-dependent, conserved site
InterPro IPR012309 DNA ligase, ATP-dependent, C-terminal
InterPro IPR012308 DNA ligase, ATP-dependent, N-terminal
InterPro IPR012340 Nucleic acid-binding, OB-fold
Protein Ontology PR:000009800 DNA ligase 1
References (Earliest) J:19305 Savini E, et al., Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme. Gene. 1994 Jul 8;144(2):253-7
(Latest) J:199856 Caruana G, et al., Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease. PLoS One. 2013;8(3):e55429
All references(51)
Other
accession IDs
MGD-MRK-18597, MGI:2142100

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory