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Lig1 Gene Detail
Summary
  • Symbol
    Lig1
  • Name
    ligase I, DNA, ATP-dependent
  • Synonyms
    LigI, mLigI
  • Feature Type
    protein coding gene
  • IDs
    MGI:101789
    NCBI Gene: 16881
  • Gene Overview
    MyGene.info: LIG1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:13277313-13311427 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 7.82 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    214 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101789
protein coding gene Chr7:13277283-13311433 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031671
protein coding gene Chr7:10671256-10707697 (+)
A/J MGP_AJ_G0031645
protein coding gene Chr7:10533641-10568664 (+)
AKR/J MGP_AKRJ_G0031568
protein coding gene Chr7:10779795-10813106 (+)
BALB/cJ MGP_BALBcJ_G0031650
protein coding gene Chr7:10617383-10651450 (+)
C3H/HeJ MGP_C3HHeJ_G0031371
protein coding gene Chr7:10924682-10958644 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032114
protein coding gene Chr7:11250726-11285636 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029205
protein coding gene Chr7:12368629-12404596 (+)
CAST/EiJ MGP_CASTEiJ_G0030729
protein coding gene Chr7:8394853-8433731 (+)
CBA/J MGP_CBAJ_G0031329
protein coding gene Chr7:11451630-11488287 (+)
DBA/2J MGP_DBA2J_G0031487
protein coding gene Chr7:10394323-10428333 (+)
FVB/NJ MGP_FVBNJ_G0031443
protein coding gene Chr7:10418722-10454593 (+)
LP/J MGP_LPJ_G0031573
protein coding gene Chr7:10781428-10816162 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031478
protein coding gene Chr7:11537214-11572351 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032144
protein coding gene Chr7:10547878-10584695 (+)
PWK/PhJ MGP_PWKPhJ_G0030457
protein coding gene Chr7:8861922-8896267 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030283
protein coding gene Chr7:6625472-6659336 (+)
WSB/EiJ MGP_WSBEiJ_G0030824
protein coding gene Chr7:10584061-10620923 (+)



Homology
more
  • Human Ortholog
    LIG1, DNA ligase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LIG1, DNA ligase 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3978
    neXtProt AC: NX_P18858
    UniProt: P18858

  • Chr Location
    19q13.33; chr19:48115445-48170603 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired fetal hematopoiesis, develop anemia, and die by E16.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16881 NCBI Gene Model | MGI Sequence Detail 34115 C57BL/6J ±  kb
    transcript NM_001199310 RefSeq | MGI Sequence Detail 3194 C57BL/6  
    polypeptide P37913 UniProt | EBI | MGI Sequence Detail 916 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • EC
    • InterPro Domains
      IPR000977 DNA ligase, ATP-dependent
      IPR012310 DNA ligase, ATP-dependent, central
      IPR016059 DNA ligase, ATP-dependent, conserved site
      IPR012309 DNA ligase, ATP-dependent, C-terminal
      IPR012308 DNA ligase, ATP-dependent, N-terminal
      IPR036599 DNA ligase, ATP-dependent, N-terminal domain superfamily
      IPR012340 Nucleic acid-binding, OB-fold
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18597, MGI:2142100
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:19305 Savini E, et al., Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme. Gene. 1994 Jul 8;144(2):253-7
    • Latest
      J:199856 Caruana G, et al., Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease. PLoS One. 2013;8(3):e55429

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory