Lig1
Gene Detail

Symbol Name ID

Lig1 ligase I, DNA, ATP-dependent MGI:101789

Synonyms

LigI, mLigI

Feature Type

protein coding gene

Genetic Map

Chromosome 7

7.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr7:13277283-13311433 bp, + strand From VEGA annotation of GRCm38   34151 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ATP-dependent DNA ligase, eukaryotic type
Gene Tree: Lig1

Human homologs

Human Homolog		LIG1, ligase I, DNA, ATP-dependent
NCBI Gene ID		3978
neXtProt AC		NX_P18858
Human Chr (Location)		19q13.2-q13.3; chr19:48618703-48673560 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(20) : Targeted(4) Gene trapped(16)
 

Mice homozygous for a null allele exhibit impaired fetal hematopoiesis, develop anemia, and die by E16.5.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cell cycle, cell division, ...
Component	chromosome, mitochondrion, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (171)    Tissues (109)    Images (36)
Theiler Stages: 1, 2, 3, 4, 22, 23

Assay Type	Results
RNA in situ	163
RT-PCR	8

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030683 (Evidence)
Ensembl Gene Model	ENSMUSG00000056394 (Evidence)
Entrez Gene	16881 (Evidence)
DFCI	TC1573061
DoTS	DT.101307261, DT.532319, DT.94407457
EC	6.5.1.1
International Mouse Knockout Project Status	Lig1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030683	VEGA Gene Model | MGI Sequence Detail	34151	C57BL/6J
transcript	OTTMUST00000075950	VEGA | MGI Sequence Detail	2317	Not Applicable
polypeptide	OTTMUSP00000039904	VEGA | MGI Sequence Detail	687	Not Applicable

All sequences(90) RefSeq(6) UniProt(9)

Polymorphisms

RFLP(3) : SNPs(193 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000977	DNA ligase, ATP-dependent
InterPro	IPR012310	DNA ligase, ATP-dependent, central
InterPro	IPR016059	DNA ligase, ATP-dependent, conserved site
InterPro	IPR012309	DNA ligase, ATP-dependent, C-terminal
InterPro	IPR012308	DNA ligase, ATP-dependent, N-terminal
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR016027	Nucleic acid-binding, OB-fold-like
Protein Ontology	PR:000009800	DNA ligase 1

References

(Earliest) J:19305 Savini E, et al., Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme. Gene. 1994 Jul 8;144(2):253-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)

Other accession IDs

MGD-MRK-18597, MGI:2142100