About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lig1
ligase I, DNA, ATP-dependent
MGI:101789
35 phenotypes from 4 alleles in 4 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Lig1m1Anu/Lig1m1Anu
involves: C3H/HeH * C57BL/6JAnu
anemia J:199856
increased nucleated erythrocyte cell number J:199856
pale liver J:199856
Lig1tm1Dwm/Lig1tm1Dwm
involves: 129P2/OlaHsd
abnormal definitive hematopoiesis J:75962
abnormal DNA replication J:75962
anemia J:75962
normal cellular phenotype J:75962
chromosomal instability J:75962
decreased fibroblast proliferation J:75962
decreased hematocrit J:75962
enlarged spleen J:75962
increased bone marrow cell number J:75962
macrocytosis J:75962
reticulocytosis J:75962
Lig1tm1Dwm/Lig1tm1Dwm
involves: 129P2/OlaHsd * BALB/c
abnormal blood cell morphology/development J:76371
abnormal erythropoiesis J:76371
abnormal liver development J:76371
absent erythrocytes J:76371
anemia J:76371
anisocytosis J:76371
decreased embryo size J:76371
decreased erythroid progenitor cell number J:76371
embryonic growth retardation J:76371
lethality throughout fetal growth and development, complete penetrance J:76371
liver hypoplasia J:76371
pallor J:76371
poikilocytosis J:76371
small liver J:76371
Lig1tm2Dwm/Lig1tm2Dwm
involves: 129P2/OlaHsd
abnormal erythropoiesis J:75962
anemia J:75962
lethality throughout fetal growth and development, complete penetrance J:75962
Lig1tm3Dwm/Lig1tm3Dwm
involves: 129P2/OlaHsd * C57BL/6
abnormal bone marrow cell physiology J:77902
abnormal spleen physiology J:77902
abnormal thymus physiology J:77902
chromosomal instability J:77902
decreased body weight J:77902
decreased fibroblast proliferation J:77902
enlarged spleen J:77902
normal hematopoietic system phenotype J:77902
increased adenocarcinoma incidence J:77902
increased lymphoma incidence J:77902
increased tumor incidence J:77902
postnatal growth retardation J:77902
reticulocytosis J:77902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/30/2024
MGI 6.23
The Jackson Laboratory