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Cd80 Gene Detail
Summary
  • Symbol
    Cd80
  • Name
    CD80 antigen
  • Synonyms
    B7-1, B7.1, Cd28l, Ly53, Ly-53
  • Feature Type
    protein coding gene
  • IDs
    MGI:101775
    NCBI Gene: 12519
  • Gene Overview
    MyGene.info: CD80
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38457431-38495958 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.86 cM, cytoband B5
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101775
protein coding gene Chr16:38457431-38495958 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022816
protein coding gene Chr16:36988893-37017867 (+)
A/J MGP_AJ_G0022781
protein coding gene Chr16:35151040-35178982 (+)
AKR/J MGP_AKRJ_G0022753
protein coding gene Chr16:36487257-36519572 (+)
BALB/cJ MGP_BALBcJ_G0022782
protein coding gene Chr16:35273667-35303475 (+)
C3H/HeJ MGP_C3HHeJ_G0022546
protein coding gene Chr16:36591618-36624344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023229
protein coding gene Chr16:37830924-37862217 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020744
protein coding gene Chr16:35527527-35556082 (+)
CAST/EiJ MGP_CASTEiJ_G0022072
protein coding gene Chr16:36746132-36779157 (+)
CBA/J MGP_CBAJ_G0022517
protein coding gene Chr16:39489803-39519236 (+)
DBA/2J MGP_DBA2J_G0022649
protein coding gene Chr16:35036377-35064347 (+)
FVB/NJ MGP_FVBNJ_G0022624
protein coding gene Chr16:35066603-35094736 (+)
LP/J MGP_LPJ_G0022717
protein coding gene Chr16:36668141-36698144 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022643
protein coding gene Chr16:38604814-38634739 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023244
protein coding gene Chr16:36450759-36482018 (+)
PWK/PhJ MGP_PWKPhJ_G0021812
protein coding gene Chr16:35451050-35480084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021643
protein coding gene Chr16:36344806-36374244 (+)
WSB/EiJ MGP_WSBEiJ_G0022116
protein coding gene Chr16:36521413-36550767 (+)



Homology
more
  • Human Ortholog
    CD80, CD80 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD80, CD80 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
  • Links
    NCBI Gene ID: 941
    neXtProt AC: NX_P33681
    UniProt: P33681

  • Chr Location
    3q13.33; chr3:119523909-119559709 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 7 genetic backgrounds
    45 phenotypes from multigenic genotypes
    169 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a 70% reduction in the mixed lymphocyte response in LPS- and dextran sulfate-stimulated B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12519 NCBI Gene Model | MGI Sequence Detail 38528 C57BL/6J ±  kb
    transcript NM_001359898 RefSeq | MGI Sequence Detail 2688 C57BL/6  
    polypeptide Q00609 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 12
      cDNA 22

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11996, MGD-MRK-12039, MGD-MRK-1846, MGD-MRK-18582
    References
    more
    • Summaries
      All 308
      Developmental Gene Expression 3
      Diseases 5
      Gene Ontology 18
      Phenotypes 169
    • Earliest
      J:10835 Kubota H, et al., Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation. J Immunol. 1990 Dec 1;145(11):3924-31
    • Latest
      J:265714 Cobo-Vuilleumier N, et al., LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nat Commun. 2018 Apr 16;9(1):1488

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory