About   Help   FAQ
Cd80
Gene Detail
Symbol

Name
ID
Cd80
CD80 antigen
MGI:101775
Synonyms
B7-1, B7.1, Cd28l, Ly53, Ly-53
Feature Type
protein coding gene
Genetic Map
Chromosome 16
26.86 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr16:38458933-38486933 bp, + strand
From Ensembl annotation of GRCm38

  28001 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: B-lymphocyte restricted antigen B7
Gene Tree: Cd80

Human
homologs
Human Homolog CD80, CD80 molecule
NCBI Gene ID 941
neXtProt AC  NX_P33681
Human Synonyms  B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Human Chr (Location)  3q13.3-q21; chr3:119524293-119559634 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in a 70% reduction in the mixed lymphocyte response in LPS- and dextran sulfate-stimulated B cells.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Cd80 interacts with 85 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (2)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 10
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(12) cDNA(21)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000075122 (Evidence)
Entrez Gene12519 (Evidence)
UniGene89474
DFCITC1589926, TC1607549, TC1681520
DoTSDT.40158015, DT.40158016, DT.55151868, DT.101359685, DT.101199618
NIA Mouse Gene IndexU040808
Consensus CDS ProjectCCDS28168.1
International Mouse Knockout Project StatusCd80
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075122 Ensembl Gene Model | MGI Sequence Detail 28001 C57BL/6J ±  kb
transcript ENSMUST00000099816 Ensembl | MGI Sequence Detail 1701 Not Applicable 
polypeptide ENSMUSP00000097404 Ensembl | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(10) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001438 CD80 molecule
References
(Earliest) J:10835 Kubota H, et al., Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation. J Immunol. 1990 Dec 1;145(11):3924-31
(Latest) J:212412 Newman RG, et al., Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood. 2014 May 8;123(19):3045-55
All references(244)
Other
accession IDs
MGD-MRK-11996, MGD-MRK-12039, MGD-MRK-1846, MGD-MRK-18582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory