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Cd80 Gene Detail
Summary
  • Symbol
    Cd80
  • Name
    CD80 antigen
  • Synonyms
    B7-1, B7.1, Cd28l, Ly53, Ly-53
  • Feature Type
    protein coding gene
  • IDs
    MGI:101775
    NCBI Gene: 12519
  • Gene Overview
    MyGene.info: CD80
Location & Maps
more
  • Sequence Map
    Chr16:38458933-38486933 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28001 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.86 cM, cytoband B5
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CD80, CD80 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD80, CD80 molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
  • Links
    NCBI Gene ID: 941
    neXtProt AC: NX_P33681

  • Chr Location
    3q13.3-q21; chr3:119523948-119559634 (-)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 7 genetic backgrounds
    45 phenotypes from multigenic genotypes
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Gene trapped
    20
  • Targeted
    4
  • Transgenic
    4
  • Incidental Mutations
Homozygous mutation of this gene results in a 70% reduction in the mixed lymphocyte response in LPS- and dextran sulfate-stimulated B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075122 Ensembl Gene Model | MGI Sequence Detail 28001 C57BL/6J ±  kb
transcript ENSMUST00000099816 Ensembl | MGI Sequence Detail 1701 Not Applicable  
polypeptide ENSMUSP00000097404 Ensembl | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    222 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 12
    cDNA 21

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-11996, MGD-MRK-12039, MGD-MRK-1846, MGD-MRK-18582
References
more
  • Summaries
    All 242
    Developmental Gene Expression 3
    Diseases 5
    Gene Ontology 14
    Phenotypes 159
  • Earliest
    J:10835 Kubota H, et al., Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation. J Immunol. 1990 Dec 1;145(11):3924-31
  • Latest
    J:221363 Matheu MP, et al., Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming. Nat Commun. 2015;6:6219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory