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Cdk5r1
Gene Detail
 Symbol
Name
ID
Cdk5r1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
MGI:101764
Synonyms D11Bwg0379e, p25, p35
Feature Type protein coding gene
Genetic Map
Chromosome 11
47.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:80477023-80481184 bp, + strand
From VEGA annotation of GRCm38

  4162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cyclin-dependent kinase 5, regulatory subunit (activating)
Gene Tree: Cdk5r1

Human
homologs
Human Homolog CDK5R1, cyclin-dependent kinase 5, regulatory subunit 1 (p35)
NCBI Gene ID 8851
neXtProt AC  NX_Q15078
Human Synonyms  CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
Human Chr (Location)  17q11.2; chr17:32487087-32491253 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in structural abnormalities of the brain, such as a small corpus callosum, delaminated cerebral cortex, dense molecular layer, and abnormal laminar structure of the hippocampus and dentate gyrus.
 
Interactions
Cdk5r1 interacts with 315 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process axonal fasciculation, axon guidance, ...
Component axon, contractile fiber, ...
Function cadherin binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (195)    Tissues (156)    Images (26)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 152
Western blot 43
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(3) cDNA(17) Primer pair(4) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000000218 (Evidence)
Ensembl Gene ModelENSMUSG00000048895 (Evidence)
Entrez Gene12569 (Evidence)
DFCITC1575524, TC1592875, TC1722934
DoTSDT.101404138, DT.533410
NIA Mouse Gene IndexU013056
Consensus CDS ProjectCCDS25134.1
International Mouse Knockout Project StatusCdk5r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000218 VEGA Gene Model | MGI Sequence Detail 4162 C57BL/6J ±  kb
transcript OTTMUST00000000641 VEGA | MGI Sequence Detail 4162 Not Applicable 
polypeptide OTTMUSP00000000280 VEGA | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(7)
Polymorphisms RFLP(2) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004944 Cyclin-dependent kinase 5 activator
InterPro IPR013763 Cyclin-like
Protein Ontology PR:000005259 cyclin-dependent kinase 5 activator 1
References (Earliest) J:20526 Tsai LH, et al., p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature. 1994 Sep 29;371(6496):419-23
(Latest) J:208030 Seo J, et al., Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Abeta-Induced Cognitive Impairment. Cell. 2014 Apr 10;157(2):486-98
All references(119)
Other
accession IDs
MGD-MRK-18570, MGD-MRK-34066, MGI:106373

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory