About   Help   FAQ
Cdk5r1
Gene Detail
Symbol

Name
ID
Cdk5r1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
MGI:101764
Synonyms
D11Bwg0379e, p25, p35
Feature Type
protein coding gene
Genetic Map
Chromosome 11
47.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:80477023-80481184 bp, + strand
From VEGA annotation of GRCm38

  4162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK5R1
Protein SuperFamily: cyclin-dependent kinase 5, regulatory subunit (activating)
Gene Tree: Cdk5r1

Human
homologs
CDK5R1, cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8851
neXtProt AC: NX_Q15078

Human Synonyms: CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a

Human Chr (Location): 17q11.2; chr17:32487087-32491254 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(6) Transgenic(3)
Genomic Mutations involving Cdk5r1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of the gene results in structural abnormalities of the brain such as a small corpus callosum and delaminated cerebral cortex. Mice show hyperactivity and decreased locomotion in response to stimulants.
 
Human Diseases Modeled in Mice Using Cdk5r1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Cdk5r1 interacts with 315 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process activation of protein kinase activity, axonal fasciculation, ...
Component axon, contractile fiber, ...
Function cadherin binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (195)    Tissues (156)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 152
Western blot 43
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk5r1 ; ZFIN cdk5r1b    NEW 
Molecular
reagents
All nucleic(25) Genomic(3) cDNA(17) Primer pair(4) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000000218 (Evidence)
Ensembl Gene Model ENSMUSG00000048895 (Evidence)
Entrez Gene 12569 (Evidence)
DFCI TC1575524, TC1592875, TC1722934
DoTS DT.101404138, DT.533410
NIA Mouse Gene Index U013056
Consensus CDS Project CCDS25134.1
International Mouse Phenotyping Consortium Status Cdk5r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000218 VEGA Gene Model | MGI Sequence Detail 4162 C57BL/6J ±  kb
transcript OTTMUST00000000641 VEGA | MGI Sequence Detail 4162 Not Applicable 
polypeptide OTTMUSP00000000280 VEGA | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004944 Cyclin-dependent kinase 5 activator
InterPro IPR013763 Cyclin-like
Protein Ontology PR:000005259 cyclin-dependent kinase 5 activator 1
References
(Earliest) J:20526 Tsai LH, et al., p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature. 1994 Sep 29;371(6496):419-23
(Latest) J:221676 Miller N, et al., Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. J Neurosci. 2015 Apr 15;35(15):6038-50
All references(121)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-18570, MGD-MRK-34066, MGI:106373

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory