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Cfl2
Gene Detail
Symbol

Name
ID
Cfl2
cofilin 2, muscle
MGI:101763
Feature Type
protein coding gene
Genetic Map
Chromosome 12
23.75 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:54858817-54862877 bp, - strand
From Ensembl annotation of GRCm38

  4061 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CFL2
Protein SuperFamily: ADF/cofilin
Gene Tree: Cfl2

Human
homologs
CFL2, cofilin 2 (muscle)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1073
neXtProt AC: NX_Q9Y281

Human Synonyms: NEM7

Human Chr (Location): 14q12; chr14:34710382-34714823 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CFL2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(23) Targeted(4)
 
Mice homozygous for a knock-out allele exhibit postnatal growth retardation and lethality associated with muscle weakness and skeletal muscle fiber degeneration.
 
Interactions
Cfl2 interacts with 376 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process actin filament depolymerization, actin filament organization, ...
Component actin cytoskeleton, cell, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(109)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cfl2    NEW 
Molecular
reagents
All nucleic(112) cDNA(111) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000062929 (Evidence)
Entrez Gene 12632 (Evidence)
UniGene 276826
DFCI TC1574361, TC1595916
DoTS DT.493728
NIA Mouse Gene Index U033952
Consensus CDS Project CCDS36448.1
International Mouse Phenotyping Consortium Status Cfl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062929 Ensembl Gene Model | MGI Sequence Detail 4061 C57BL/6J ±  kb
transcript ENSMUST00000078124 Ensembl | MGI Sequence Detail 2940 Not Applicable 
polypeptide ENSMUSP00000077262 Ensembl | MGI Sequence Detail 166 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
InterPro IPR017904 ADF/Cofilin/Destrin
Protein Ontology PR:000005386 cofilin-2
References
(Earliest) J:18330 Ono S, et al., Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle. J Biol Chem. 1994 May 27;269(21):15280-6
(Latest) J:211364 Yuan B, et al., A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice. Am J Pathol. 2014 Jul;184(7):1967-80
All references(38)
Other
accession IDs
MGD-MRK-18569

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory