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Cfl2
Gene Detail
 Symbol
Name
ID
Cfl2
cofilin 2, muscle
MGI:101763
Feature Type protein coding gene
Genetic Map
Chromosome 12
23.75 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:54858817-54862877 bp, - strand
From NCBI annotation of GRCm38

  4061 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ADF/cofilin
Gene Tree: Cfl2

Human
homologs
Human Homolog CFL2, cofilin 2 (muscle)
NCBI Gene ID 1073
neXtProt AC  NX_Q9Y281
Human Synonyms  NEM7
Human Chr (Location)  14q12; chr14:34710382-34714823 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CFL2
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(23) Targeted(4)
 
Mice homozygous for a knock-out allele exhibit postnatal growth retardation and lethality associated with muscle weakness and skeletal muscle fiber degeneration.
 
Interactions
Cfl2 interacts with 376 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process actin filament depolymerization, actin filament organization, ...
Component actin cytoskeleton, cell, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 1
cDNA source data(109)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) cDNA(111) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000062929 (Evidence)
Entrez Gene12632 (Evidence)
UniGene276826
DFCITC1574361, TC1595916
DoTSDT.493728
NIA Mouse Gene IndexU033952
Consensus CDS ProjectCCDS36448.1
International Mouse Knockout Project StatusCfl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12632 NCBI Gene Model | MGI Sequence Detail 4061 C57BL/6J ±  kb
transcript NM_007688 RefSeq | MGI Sequence Detail 2940 Not Specified 
polypeptide P45591 UniProt | EBI | MGI Sequence Detail 166 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
InterPro IPR017904 ADF/Cofilin/Destrin
Protein Ontology PR:000005386 cofilin-2
Graphical View of Protein Domain Structure
References (Earliest) J:18330 Ono S, et al., Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle. J Biol Chem. 1994 May 27;269(21):15280-6
(Latest) J:182571 Agrawal PB, et al., Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet. 2012 Mar 5;
All references(39)
Other
accession IDs
MGD-MRK-18569

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory