Cfl2
Gene Detail

Symbol Name ID

Cfl2 cofilin 2, muscle MGI:101763

Feature Type

protein coding gene

Genetic Map

Chromosome 12

23.75 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:54858817-54862877 bp, - strand From NCBI annotation of GRCm38   4061 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128254  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ADF/cofilin
Gene Tree: Cfl2

Human homologs

Human Homolog		CFL2, cofilin 2 (muscle)
NCBI Gene ID		1073
neXtProt AC		NX_Q9Y281
Human Synonyms		NEM7
Human Chr (Location)		14q12; chr14:35179588-35184029 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CFL2

Alleles and phenotypes

All alleles(27) : Targeted(4) Gene trapped(23)
 

Mice homozygous for a knock-out allele exhibit postnatal growth retardation and lethality associated with muscle weakness and skeletal muscle fiber degeneration.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	actin filament depolymerization
Component	actin cytoskeleton, cytoplasm, ...
Function	actin binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	1

cDNA source data(104)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(107) cDNA(106) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000062929 (Evidence)
Entrez Gene	12632 (Evidence)
UniGene	276826
DFCI	TC1574361, TC1595916
DoTS	DT.493728
NIA Mouse Gene Index	U033952
Consensus CDS Project	CCDS36448.1
International Mouse Knockout Project Status	Cfl2

Sequences

Length	Strain/Species
genomic	12632	NCBI Gene Model | MGI Sequence Detail	4061	C57BL/6J
transcript	NM_007688	RefSeq | MGI Sequence Detail	2940	Not Specified
polypeptide	P45591	UniProt | EBI | MGI Sequence Detail	166	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002108	Actin-binding, cofilin/tropomyosin type
InterPro	IPR017904	ADF/Cofilin/Destrin
Protein Ontology	PR:000005386	cofilin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:18330 Ono S, et al., Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle. J Biol Chem. 1994 May 27;269(21):15280-6
(Latest) J:182571 Agrawal PB, et al., Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet. 2012 Mar 5;
All references(38)

Other accession IDs

MGD-MRK-18569