Cfl1 MGI Mouse Gene Detail - MGI:101757

Cfl1 Gene Detail

Symbol

Cfl1
Name

cofilin 1, non-muscle
Synonyms

Cof, cofilin, n-cofilin

Feature Type

protein coding gene
IDs

MGI:101757
NCBI Gene: 12631
Gene Overview

MyGene.info: CFL1
Alliance

gene page

Sequence Map

Chr19:5490455-5495201 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

4747 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM
Mapping Data

2 experiments

Human Ortholog

CFL1, cofilin 1

Vertebrate Orthologs

8

Human Ortholog

CFL1, cofilin 1
Orthology source: HomoloGene, HGNC
Synonyms

CFL, cofilin, HEL-S-15
Links

HGNC:1874

NCBI Gene ID: 1072

neXtProt AC: NX_P23528

UniProt: P23528
Chr Location

11q13.1; chr11:65854811-65858333 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 99735
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CFL1
Protein SuperFamily

ADF/cofilin
Gene Tree

Cfl1

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Phenotype Summary

36 phenotypes from 4 alleles in 4 genetic backgrounds
18 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (ENU)

1
Gene trapped

26
Targeted

6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

20 strains or lines available

Homozygous null mice display embryonic lethality with impaired neural crest cell migration, an open neural tube, and abnormal somite and eye development.

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All GO Annotations

77
GO References

17

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

62
Tissues

19
cDNA Data

504
Literature Summary

33

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cfl1

ZFIN cfl1

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Cfl1 interacts with 92 markers (Mir15b, Mir17, Mir19b-1, ...) View All

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All Sequences

37
RefSeq

2
UniProt

4
CCDS

CCDS84409.1
UniGene

329655

			Length	Strain/Species	Flank
genomic	OTTMUSG00000060221	VEGA Gene Model \| MGI Sequence Detail	4747	C57BL/6J	± kb
transcript	OTTMUST00000147413	VEGA \| MGI Sequence Detail	2354	Not Applicable
polypeptide	OTTMUSP00000076712	VEGA \| MGI Sequence Detail	166	Not Applicable

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SNPs within 2kb

21 from dbSNP Build 142

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UniProt

4 Sequences
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR017904 ADF/Cofilin

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR027234 Cofilin 1

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All nucleic 510

Genomic 1

cDNA 506

Primer pair 3

Microarray probesets 3

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MGD-MRK-18563, MGD-MRK-2048, MGI:2147462

Summaries

All 114

Developmental Gene Expression 33

Gene Ontology 17

Phenotypes 22
Earliest

J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
Latest

J:246655 Wang JC, et al., The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse. J Cell Sci. 2017 Mar 15;130(6):1094-1109

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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