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Cfl1
Gene Detail
Symbol

Name
ID
Cfl1
cofilin 1, non-muscle
MGI:101757
Synonyms
Cof, cofilin, n-cofilin
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:5490485-5494029 bp, + strand
From Ensembl annotation of GRCm38

  3545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: ADF/cofilin
Gene Tree: Cfl1

Human
homologs
Human Homolog CFL1, cofilin 1 (non-muscle)
NCBI Gene ID 1072
neXtProt AC  NX_P23528
Human Synonyms  CFL, HEL-S-15
Human Chr (Location)  11q13; chr11:65854811-65858333 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Chemically induced (ENU)(1) Gene trapped(26) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mice display embryonic lethality with impaired neural crest cell migration, an open neural tube, and abnormal somite and eye development.
 
Interactions
Cfl1 interacts with 93 markers (Mir15b, Mir17, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process actin filament depolymerization, actin filament organization, ...
Component actin cytoskeleton, cell-cell junction, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (38)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
Western blot 26
RT-PCR 2
cDNA source data(504)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(509) Genomic(1) cDNA(505) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000056201 (Evidence)
Entrez Gene12631 (Evidence)
UniGene329655
DFCITC1573890, TC1595977
International Mouse Knockout Project StatusCfl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056201 Ensembl Gene Model | MGI Sequence Detail 3545 C57BL/6J ±  kb
transcript ENSMUST00000116560 Ensembl | MGI Sequence Detail 1148 Not Applicable 
polypeptide ENSMUSP00000112259 Ensembl | MGI Sequence Detail 227 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
InterPro IPR017904 ADF/Cofilin/Destrin
InterPro IPR027234 Cofilin 1/2
Protein Ontology PR:000005385 cofilin-1
References
(Earliest) J:10541 Moriyama K, et al., Nucleotide sequence of mouse cofilin cDNA. Nucleic Acids Res. 1990 May 25;18(10):3053
(Latest) J:210536 Collazo J, et al., Cofilin drives cell-invasive and metastatic responses to TGF-beta in prostate cancer. Cancer Res. 2014 Apr 15;74(8):2362-73
All references(75)
Other
accession IDs
MGD-MRK-18563, MGD-MRK-2048, MGI:2147462

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory