Cfl1
Gene Detail

Symbol Name ID

Cfl1 cofilin 1, non-muscle MGI:101757

Synonyms

Cof, cofilin

Feature Type

protein coding gene

Genetic Map

Chromosome 19

4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:5490485-5494029 bp, + strand From Ensembl annotation of GRCm38   3545 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:99735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: ADF/cofilin
Gene Tree: Cfl1

Human homologs

Human Homolog		CFL1, cofilin 1 (non-muscle)
NCBI Gene ID		1072
neXtProt AC		NX_P23528
Human Synonyms		CFL
Human Chr (Location)		11q13; chr11:65622282-65625804 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(32) : Targeted(5) Gene trapped(26) Chemically induced(1)
 

Homozygous null mice display embryonic lethality with impaired neural crest cell migration, an open neural tube, and abnormal somite and eye development.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	actin filament depolymerization, actin filament organization, ...
Component	actin cytoskeleton, cell leading edge, ...
Function	actin binding

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (42)    Tissues (16)   
Theiler Stages: 1, 2, 3, 4, 5, 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	10
Western blot	30
RT-PCR	2

cDNA source data(498)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(503) Genomic(1) cDNA(499) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000056201 (Evidence)
Entrez Gene	12631 (Evidence)
UniGene	329655
DFCI	TC1573890, TC1595977
International Mouse Knockout Project Status	Cfl1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000056201	Ensembl Gene Model | MGI Sequence Detail	3545	C57BL/6J
transcript	ENSMUST00000116560	Ensembl | MGI Sequence Detail	1148	Not Applicable
polypeptide	ENSMUSP00000112259	Ensembl | MGI Sequence Detail	227	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002108	Actin-binding, cofilin/tropomyosin type
InterPro	IPR017904	ADF/Cofilin/Destrin
InterPro	IPR027234	Cofilin 1/2
Protein Ontology	PR:000005385	cofilin-1

References

(Earliest) J:10541 Moriyama K, et al., Nucleotide sequence of mouse cofilin cDNA. Nucleic Acids Res. 1990 May 25;18(10):3053
(Latest) J:194042 Mahaffey JP, et al., Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
All references(69)

Other accession IDs

MGD-MRK-18563, MGD-MRK-2048, MGI:2147462