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Cfl1 Gene Detail
Summary
  • Symbol
    Cfl1
  • Name
    cofilin 1, non-muscle
  • Synonyms
    Cof, cofilin, n-cofilin
  • Feature Type
    protein coding gene
  • IDs
    MGI:101757
    NCBI Gene: 12631
  • Gene Overview
    MyGene.info: CFL1
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CFL1, cofilin 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CFL1, cofilin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CFL, cofilin, HEL-S-15
  • Links
    NCBI Gene ID: 1072
    neXtProt AC: NX_P23528
    UniProt: P23528

  • Chr Location
    11q13.1; chr11:65854811-65858333 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 4 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with impaired neural crest cell migration, an open neural tube, and abnormal somite and eye development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060221 VEGA Gene Model | MGI Sequence Detail 4747 C57BL/6J ±  kb
    transcript OTTMUST00000147413 VEGA | MGI Sequence Detail 2354 Not Applicable  
    polypeptide OTTMUSP00000076712 VEGA | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      21 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 512
      Genomic 1
      cDNA 507
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18563, MGD-MRK-2048, MGI:2147462
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 34
      Gene Ontology 16
      Phenotypes 22
    • Earliest
      J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
    • Latest
      J:259495 Pyronneau A, et al., Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome. Sci Signal. 2017 Nov 7;10(504)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory