Cfl1
Gene Detail

Symbol Name ID

Cfl1 cofilin 1, non-muscle MGI:101757

Synonyms

Cof, cofilin, n-cofilin

Feature Type

protein coding gene

Genetic Map

Chromosome 19

4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:5490485-5494029 bp, + strand From Ensembl annotation of GRCm38   3545 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:99735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: ADF/cofilin
Gene Tree: Cfl1

Human homologs

Human Homolog		CFL1, cofilin 1 (non-muscle)
NCBI Gene ID		1072
neXtProt AC		NX_P23528
Human Synonyms		CFL, HEL-S-15
Human Chr (Location)		11q13; chr11:65854811-65858333 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(32) : Chemically induced (ENU)(1) Gene trapped(26) Targeted(5)
Incidental mutations (data from APF )
 

Homozygous null mice display embryonic lethality with impaired neural crest cell migration, an open neural tube, and abnormal somite and eye development.

 

Interactions

Cfl1 interacts with 93 markers (Mir15b, Mir17, Mir19b-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	actin filament depolymerization, actin filament organization, ...
Component	actin cytoskeleton, cell-cell junction, ...
Function	actin binding

External Resources: FuncBase

Expression

Literature Summary: (22 records)

Data Summary: Results (42)    Tissues (16)   
Theiler Stages: 1, 2, 3, 4, 5, 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	10
Western blot	30
RT-PCR	2

cDNA source data(504)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(509) Genomic(1) cDNA(505) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000056201 (Evidence)
Entrez Gene	12631 (Evidence)
UniGene	329655
DFCI	TC1573890, TC1595977
International Mouse Knockout Project Status	Cfl1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000056201	Ensembl Gene Model | MGI Sequence Detail	3545	C57BL/6J
transcript	ENSMUST00000116560	Ensembl | MGI Sequence Detail	1148	Not Applicable
polypeptide	ENSMUSP00000112259	Ensembl | MGI Sequence Detail	227	Not Applicable

All sequences(32) RefSeq(2) UniProt(4)

Polymorphisms

SNPs within 2kb(18 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002108	Actin-binding, cofilin/tropomyosin type
InterPro	IPR017904	ADF/Cofilin/Destrin
InterPro	IPR027234	Cofilin 1/2
Protein Ontology	PR:000005385	cofilin-1

References

(Earliest) J:10541 Moriyama K, et al., Nucleotide sequence of mouse cofilin cDNA. Nucleic Acids Res. 1990 May 25;18(10):3053
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(72)

Other accession IDs

MGD-MRK-18563, MGD-MRK-2048, MGI:2147462