Cfl1 MGI Mouse Gene Detail - MGI:101757

Symbol

Cfl1
Name

cofilin 1, non-muscle
Synonyms

Cof, cofilin, n-cofilin

Feature Type

protein coding gene
IDs

MGI:101757
NCBI Gene: 12631
Gene Overview

MyGene.info: CFL1
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr19:5540483-5544059 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM
Mapping Data

2 experiments

SNPs within 2kb

15 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101757	protein coding gene	Chr19:5540483-5545229 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024712	protein coding gene	Chr19:2459653-2463197 (+)
A/J	MGP_AJ_G0024678	protein coding gene	Chr19:2325185-2328729 (+)
AKR/J	MGP_AKRJ_G0024651	protein coding gene	Chr19:2382979-2386523 (+)
BALB/cJ	MGP_BALBcJ_G0024678	protein coding gene	Chr19:2318849-2322393 (+)
C3H/HeJ	MGP_C3HHeJ_G0024446	protein coding gene	Chr19:2393253-2396797 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025125	protein coding gene	Chr19:2517825-2521369 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022555	protein coding gene	Chr19:2228213-2231786 (+)
CAST/EiJ	MGP_CASTEiJ_G0023918	protein coding gene	Chr19:2424599-2428508 (+)
CBA/J	MGP_CBAJ_G0024418	protein coding gene	Chr19:2629097-2632641 (+)
DBA/2J	MGP_DBA2J_G0024545	protein coding gene	Chr19:2305034-2308647 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0024631	protein coding gene	Chr19:2441152-2444696 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0025173	protein coding gene	Chr19:2407764-2411306 (+)
PWK/PhJ	MGP_PWKPhJ_G0023664	protein coding gene	Chr19:2341882-2346107 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023469	protein coding gene	Chr19:2386607-2390175 (+)
WSB/EiJ	MGP_WSBEiJ_G0023980	protein coding gene	Chr19:2415349-2418893 (+)

Human Ortholog

CFL1, cofilin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CFL1, cofilin 1
Synonyms

CFL, cofilin, HEL-S-15
Links

HGNC:1874

NCBI Gene ID: 1072

neXtProt AC: NX_P23528

UniProt: P23528
Chr Location

11q13.1; chr11:65854811-65858333 (-) GRCh38.p7

Alliance of Genome Resources

Cfl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CFL1
Gene Tree

Cfl1

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Phenotype Summary

38 phenotypes from 4 alleles in 4 genetic backgrounds
18 phenotypes from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (ENU)

1
Gene trapped

22
Targeted

7
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality with impaired neural crest cell migration, an open neural tube, and abnormal somite and eye development.

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All GO Annotations

88
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

64
cDNA Data

507
Literature Summary

46

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cfl1

ZFIN cfl1

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Cfl1 interacts with 92 markers (Mir15b, Mir17, Mir19b-1, ...) View All

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All Sequences

54
RefSeq

2
UniProt

5
CCDS

CCDS84409.1

Ensembl

ENSMUSG00000056201 (Evidence)
NCBI Gene

12631

			Length	Strain/Species	Flank
genomic	12631	NCBI Gene Model \| MGI Sequence Detail	3577	C57BL/6J	± kb
transcript	NM_007687	RefSeq \| MGI Sequence Detail	1196	C57BL/6
polypeptide	P18760	UniProt \| EBI \| MGI Sequence Detail	166	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005385 cofilin-1

(term hierarchy)
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR017904 ADF/Cofilin

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR027234 Cofilin 1

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All nucleic 515

Genomic 1

cDNA 509

Primer pair 4

Other 1

Microarray probesets 3

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MGD-MRK-18563, MGD-MRK-2048, MGI:2147462

Summaries

All 143

Developmental Gene Expression 46

Gene Ontology 16

Phenotypes 31
Earliest

J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
Latest

J:303212 Limzerwala JF, et al., FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer. Nat Cancer. 2020 Oct;1:1010-1024

TSS for Cfl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154437	Chr19:5539346-5539389 (+)	-1,115 bp
Tssr154438	Chr19:5540503-5540515 (+)	26 bp
Tssr154439	Chr19:5540540-5540553 (+)	64 bp
Tssr154440	Chr19:5540585-5540634 (+)	127 bp
Tssr154441	Chr19:5543159-5543197 (+)	2,695 bp
Tssr154442	Chr19:5543440-5543455 (+)	2,965 bp
Tssr154443	Chr19:5543573-5543599 (+)	3,103 bp
Tssr154444	Chr19:5543678-5543695 (+)	3,204 bp
Tssr154445	Chr19:5543752-5543765 (+)	3,276 bp
Tssr154446	Chr19:5543784-5543810 (+)	3,314 bp
Tssr154447	Chr19:5543813-5543821 (+)	3,334 bp
Tssr154448	Chr19:5543923-5543965 (+)	3,461 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/07/2021 MGI 6.17