Cfl1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cfl1
cofilin 1, non-muscle
MGI:101757

38 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cfl1^c5/Cfl1^c5 involves: C57BL/6J	abnormal cardiac outflow tract development	J:194042
	exencephaly	J:194042
	open neural tube	J:194042
	pericardial edema	J:194042
	wavy neural tube	J:194042
Cfl1^{Gt(OST252839)Lex}/Cfl1^{Gt(OST252839)Lex} involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Cfl1^tm1.1Wit/Cfl1^tm1.1Wit involves: 129 * C57BL/6 * SJL	abnormal axon extension	J:125317
	abnormal cerebral cortex morphology	J:125317
	abnormal neurite morphology	J:125317
	abnormal neuron differentiation	J:125317
	abnormal neuronal precursor proliferation	J:125317
	ataxia	J:125317
	enlarged brain ventricles	J:125317
	postnatal growth retardation	J:125317
	postnatal lethality, incomplete penetrance	J:125317
	premature death	J:125317
	premature neuronal precursor differentiation	J:125317
	seizures	J:125317
Cfl1^tm1.1Wit/Cfl1^tm1.1Wit Tg(NPHS2-cre)295Lbh/0 involves: 129 * C57BL/6 * SJL	abnormal podocyte foot process morphology	J:165315
	abnormal response to injury	J:165315
	ascites	J:165315
	disheveled coat	J:165315
	increased circulating creatinine level	J:165315
	increased urine protein level	J:165315
	podocyte microvillus transformation	J:165315
	premature death	J:165315
	normal renal/urinary system phenotype	J:165315
Cfl1^tm1.2Wit/Cfl1^tm1.2Wit involves: 129	abnormal cardiac outflow tract development	J:194042
	abnormal eye development	J:96452
	abnormal neural crest cell delamination	J:96452
	abnormal neural crest cell migration	J:96452
	abnormal neural plate morphology	J:96452
	abnormal neural tube morphology	J:96452
	abnormal somite border morphology	J:96452
	abnormal somite development	J:96452
	absent head mesenchyme	J:96452
	decreased embryo size	J:96452
	decreased embryonic neuroepithelial cell proliferation	J:96452
	decreased embryonic neuroepithelium thickness	J:96452
	exencephaly	J:194042
	open neural tube	J:96452, J:194042
	prenatal lethality, complete penetrance	J:96452
	wavy neural tube	J:194042

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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